DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and Dhx9

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_011246220.1	Gene:	Dhx9 / 13211	MGIID:	108177	Length:	1384	Species:	Mus musculus

Alignment Length:	721	Identity:	195/721 - (27%)
Similarity:	325/721 - (45%)	Gaps:	140/721 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGM-----IGIT 119
            |:.|:::.|||......||:.:.:|..|:|...||.|||||:||: :|..:.:|..     |.:|
Mouse   383 SVLQERELLPVKKFEAEILEAISSNSVVIIRGATGCGKTTQVPQY-ILDDFIQNDRAAECNIVVT 446

  Fly   120 QPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRA-TKIRFLTDGVLLRESIKDRLLLKYS 183
            ||||::|:.||.|||.|.....|.:.||:||||.:..|. ..|.|.|.|||||:  .:..:...|
Mouse   447 QPRRISAVAVAERVAYERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRK--LEAGIRGIS 509

  Fly   184 VIILDEAHERTVNADLLFGIVKDAQKERRKQKLA--NLKVVVTSATMDIDHFGNY-FNCKGMYLE 245
            .:|:||.|||.:|.|.|..:::|.       .||  .:::|:.|||:|...|..| |||..:.:.
Mouse   510 HVIVDEIHERDINTDFLLVVLRDV-------VLAYPEVRIVLMSATIDTTMFCEYFFNCPIIEVY 567

  Fly   246 GRTYPVR-------VMHT----------KEEHED------------------------------- 262
            |||:||:       :..|          |::.||
Mouse   568 GRTFPVQEYFLEDCIQMTQFIPPPKDKKKKDKEDDGGEDDDANCNLICGDEYGPETKLSMSQLNE 632

  Fly   263 -------------YIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTGTTD 314
                         ||.|:.|.           ..||:||.|...|.::.:.:...:..   |:..
Mouse   633 KETPFELIEALLKYIETLNVP-----------GAVLVFLPGWNLIYTMQKHLENNSHF---GSHR 683

  Fly   315 LRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGL 379
            .::..|::|:.:.:|.:.|.|.|..|.||||:||||||||||..:..|||....|.|.|...:.:
Mouse   684 YQILPLHSQIPREEQRKVFDPVPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNM 748

  Fly   380 DVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRT--NPTSMVLQLLAL 442
            ....:|..||....||.|||||...|.|:...::|..|.......||:.||  :..::.::||.|
Mouse   749 TNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFDRLETHMTPEMFRTPLHEIALSIKLLRL 813

  Fly   443 DIDCNNF--DFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTAS 505
            . ....|  ..::||..|.:..|..:|..|.|:...|:  :|||||.:.:.|::|::.|:::...
Mouse   814 G-GIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDE--LTPLGRILAKLPIEPRFGKMMIMGC 875

  Fly   506 SFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQ-SKHGDHLTLLNVFNGF----LKSEK 565
            .|...:.:.::.:.......|:|..::   ....|..|. ::..||:.||:||..:    :..|:
Mouse   876 IFYVGDAVCTISAATCFPEPFISEGKR---LGYIHRNFAGNRFSDHVALLSVFQAWDDARMSGEE 937

  Fly   566 PKM-WCHDNYLNLRSLTYARNVRRQLREISEHLHLALNS-----------------SDDIEMLKK 612
            .:: :|....||:.:|......:.||:||      .:||                 .::::::..
Mouse   938 AEIRFCEQKRLNMATLRMTWEAKVQLKEI------LINSGFPEDCLLTQVFTNTGPDNNLDVVIS 996

  Fly   613 CILNGFFENIAVLQRDGFYITASGNIRSKIHPSSV------LHGKYKPSYILFTEIVQTEQTFLR 671
            .:..|.:.|:...:.....:|..|. .:.||.|||      ...||...:.:|.|.::|.....:
Mouse   997 LLAFGVYPNVCYHKEKRKILTTEGR-NALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAK 1060

  Fly   672 QVTEIS 677
            .:|.::
Mouse  1061 GMTLVT 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
Dhx9	XP_011246220.1	DSRM_DHX9_rpt1	3..71	CDD:380683
		DSRM_DHX9_rpt2	181..255	CDD:380684
		DEXHc_DHX9	333..566	CDD:350730	73/192 (38%)
		HrpA	337..>1055	CDD:224557	193/708 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810