Protein Alignment ath and mle

DIOPT Version :10

• Sequence 1: NP_609356.2
• Gene: ath / 34357
• FlyBaseID: FBgn0032194
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: XP_316626.5
• Gene: mle / 1277182
• VectorBaseID: AGAMI1_002111
• Length: 1320
• Species: Anopheles gambiae
• Alignment Length: 796
• Identity: 200/796 - (25%)
• Similarity: 337/796 - (42%)
• Gaps: 170/796 - (21%)

  Fly     1 MDSKYFATSRNDAVGPSPVKFSFKRKYDAMANSPILEKKPHVAQIKQTIAPILLTSKRTSIEQQQ 65
            :|..|.||:..|.:....:..|..|..|.:.    |:|                 |.||     :
Mosquito   344 IDEGYLATASLDQLSEDLLNESSSRLKDDLE----LQK-----------------SMRT-----R 382

  Fly    66 KSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGM-----IGITQPRRVA 125
            :.||:...|..|::.:..:..|||...||.||||||.|| :|..|..:|.     :.:|||||::
Mosquito   383 EKLPISAMRKPIMEAINEHPVVLIRGNTGCGKTTQIAQF-ILEDYINSGQGAYCNVCVTQPRRIS 446

  Fly   126 AITVARRVAQELNGTIGDTVGYTVRFEDVTSRA-TKIRFLTDGVLLRESIKDRLLLKYSVIILDE 189
            ||:|:.|:|.|....:|.||||:|||:.|..|. ..|.|.|.|||||:  .:..|...|.:|:||
Mosquito   447 AISVSERIANERCENLGVTVGYSVRFDSVLPRPYGSILFCTIGVLLRK--LEGGLRGVSHVIVDE 509

  Fly   190 AHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYF-NCKGMYLEGRTYPVRV 253
            .|||.||:|.:..:::|     ......:|:|::.|||:|...|..|| :|..:.:.||.:||..
Mosquito   510 IHERDVNSDFILVVLRD-----MVHTYPDLRVILMSATIDTSLFSRYFGDCPVLEVPGRAFPVEQ 569

  Fly   254 MHTK---------------------------------------------------EEHEDYIHTV 267
            :..:                                                   :|.:....|.
Mosquito   570 LFLEDCIELLKFRPSPPEGGAGRRKRGKDGEDDGGDGGGECDADMPECGNLNEVIDESKYSPQTK 634

  Fly   268 LVTLFHIHRTTP---------------KNHDVLIFLTGQEEIESLAQQI--RQLAKIDTTGTTDL 315
            ......|...||               :...||:||.|...|.:|.:|:  ||          :|
Mosquito   635 QAMAMMIEADTPFELITALVDYVDQQGRPGAVLVFLAGWNMIFALMRQLQPRQ----------NL 689

  Fly   316 RVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLD 380
            .|..|::||.:..|.:.| ......||||||||||||||||..:..|||....:.|.|.:.:.:.
Mosquito   690 VVLPLHSQLPREDQRKVF-NHYGQRRKVILATNIAETSITIDDVVYVIDTCKARMKLFTSHNNMT 753

  Fly   381 VLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTNPTSMVLQLLALDID 445
            ...:|..::....||.|||||.:.|.|:...::|......:...||:.||....:.|.:..|.:.
Mosquito   754 NYATVWAARTNLEQRKGRAGRVSPGMCFTLCSRARFAKLEENLTPEMFRTPLHELALSIKLLRLG 818

  Fly   446 C-NNF--DFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASSF 507
            . ..|  ..::||..|.:..|...|..:..:  .::..:||.||.:.:.|::|:..|:::.::.|
Mosquito   819 AIGKFLSKAIEPPPLDAVIEAEVLLKEMRCL--DEEEQLTPFGRILARLPIEPRLGKMMVLSTLF 881

  Fly   508 GCMEEILSLVSVLSS-DHVFVSNSEKNEMAALAHAKFQSKH--GDHLTLLNVFNGFLK----SEK 565
            |..:.:.::.:...: ..||:  .|..:...:.|.|..|..  .|::.:|..|..:.|    .|:
Mosquito   882 GLCDTLTTMAAYSGTFSEVFL--LELGQRRLMNHQKALSGQTCSDYVAMLTAFEMWSKKRAIGEE 944

  Fly   566 PKM-WCHDNYLNLRSLTYARNVRRQLREISEHLHLA--------------LNSSDDIEMLKKCIL 615
            .:| :|....|.:.:|   |::....:::.|:|.||              .|...|:||....:.
Mosquito   945 AEMRFCDWKGLQMPTL---RSIAEAKKQLIENLCLAGFPQDTMMPLRFDSENPDSDLEMAMALLC 1006

  Fly   616 NGFFENIAVLQRDGFYITASGNIRSKIHPSSVLHGKYKPS-----YILFTEIVQTEQTFLRQVTE 675
            .|.:.|:...:.....:|.... .:.:|.:|| :....|:     :.:|.|.::|.....:|::.
Mosquito  1007 IGLYPNVCYHKEKRRVLTTESR-AALMHKTSV-NCSNAPTTFPYPFFVFGEKIRTRAVSCKQMSM 1069

  Fly   676 IS-----------IEW 680
            ::           :||
Mosquito  1070 VTPIHLLLFGCKKVEW 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ath	NP_609356.2	HrpA	67..>686	CDD:441249	187/730 (26%)
mle	XP_316626.5	None