DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and Dhx57

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001157231.1	Gene:	Dhx57 / 106794	MGIID:	2147067	Length:	1388	Species:	Mus musculus

Alignment Length:	836	Identity:	234/836 - (27%)
Similarity:	369/836 - (44%)	Gaps:	189/836 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GPSPV-----------KFSFKRKYDAMANSPILEKKPHVAQIKQTIAPILLTSKRTSIEQQQKSL 68
            ||:.:           |.|:|| ||..|.|...|......|.:...|    :.:..:|.|:::.|
Mouse   486 GPASIIVENESYVNLKKRSYKR-YDRPAKSLFAENSKICRQFQMKQA----SRQFHAILQERQLL 545

  Fly    69 PVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGMIG---------ITQPRRV 124
            |.:..|..|||.|..:..|:|...||.|||||||||:|     .|.:.|         .|||||:
Mouse   546 PAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFIL-----DNSLNGPPERVANIICTQPRRI 605

  Fly   125 AAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDE 189
            :||:||.|||:|....:|.||||.:|.|.|.|.||::.:.|.|||||....|..|...:.||:||
Mouse   606 SAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDE 670

  Fly   190 AHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFN-CKGMYLEGRTYPV-- 251
            .||||..:|.|..::||...:|     |.|:|::.|||:|...|..||: |..:.:.||.:||
Mouse   671 VHERTEESDFLLLVLKDIVMQR-----ATLQVILMSATLDAGLFSKYFSYCPVITIPGRAFPVDQ 730

  Fly   252 ------------------------------------------------RV-MHTKEEHEDYIHTV 267
                                                            |: :|.::|.|....|:
Mouse   731 FFLEDALAVTRYVLQDGSPYMRSMKQIAKEKLKARHNRTAQEEVEEDLRLSLHLQDEEESVKDTI 795

  Fly   268 ----------LVTLFHIHRTTPKNHD------------------------------VLIFLTGQE 292
                      |:....:.::..|...                              ||:||.|..
Mouse   796 PDQQLDFKQLLIRYKGVSKSVIKTMSVMDFEKVNLELIEALLEWIVDGKHAYPPGAVLVFLPGLA 860

  Fly   293 EIESLAQQIRQLAKIDTTGTTDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIP 357
            ||:.|.:|::..:..:...:....:..|::.||..:|...||..|..|.|:|::||||||||||.
Mouse   861 EIKMLYEQLQSNSLFNNRRSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITID 925

  Fly   358 GIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMD-SFAD 421
            .:..|||.|.:|||.::...|::.|:...:|:|.|.||.|||||.|.|.|:..:|....: ....
Mouse   926 DVVYVIDSGKMKEKRYDAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLK 990

  Fly   422 ATQPEILRTNPTSMVLQLLALDI-DCNNFD-----FLDPPLEDGLRSAYKSLDALGAIKTGDDSY 480
            ...|||.|.....:.|::..|:: ..:|..     .::||..|.||::...|..|||:.  .|..
Mouse   991 QQLPEIQRVPLEQLCLRIKILEMFSTHNLQSVFSRLIEPPHIDSLRASKVRLRDLGALT--PDEK 1053

  Fly   481 ITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQS 545
            :||||..:...|:|.:..||:|..|.|.|::..|::.:.|:....|||..:|.|.|.....:|..
Mouse  1054 LTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAF 1118

  Fly   546 KHGDHLTLLNVFNGFLKSEKPKM-----WCHDNYLNLRSLTYARNVRRQLRE-------ISEHLH 598
            .:.|:|.||..:.|:..|.|...     :|..|:|:.|:|....:::||..|       :.|.|.
Mouse  1119 ANSDYLALLCAYKGWQLSTKESARASYNYCRQNFLSGRTLQEMASLKRQFTELLSDIGFVKEGLR 1183

  Fly   599 L--------------------ALNSSDDIEMLKKCILNGFFENIA-VLQRDG-FYITASGNIRSK 641
            .                    |..::::.:::...:....:.|:. |...:| |..|:||.:|.:
Mouse  1184 AKEIEKRAQGGDGVLDATGEEANTNAENPKLISAVLCAALYPNVVQVKTPEGKFQKTSSGVVRLQ 1248

  Fly   642 -----------------IHPSSVLH--GKYKPSYILFTEIVQTEQTFLRQVTEISI 678
                             ||||||.:  ..:...|:|:.|.::|.:.|:|..:.:|:
Mouse  1249 PKSAELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSV 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
Dhx57	NP_001157231.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..154
		UBA_DHX57	181..218	CDD:270502
		RWD	246..419	CDD:368608
		HrpA	501..1298	CDD:224557	230/813 (28%)
		DEVH box	669..672		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810