DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and dhx37

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_005172500.1	Gene:	dhx37 / 100009635	ZFINID:	ZDB-GENE-030131-4505	Length:	1153	Species:	Danio rerio

Alignment Length:	837	Identity:	247/837 - (29%)
Similarity:	396/837 - (47%)	Gaps:	171/837 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TSRNDAVGPSPVKFSFKRKYDAMANSPIL--EKKPHVAQIKQ------------TIAPILLTSKR 58
            :..:|:......|.|.::..:......:|  |.||..|.:|:            ..|..:...:.
Zfish   179 SEESDSSEEEKEKISEEKHTEEQQQQQVLKEETKPKEADMKEEKKAETWTKEDCKPAVFIPVERL 243

  Fly    59 TSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKN-GMIGITQPR 122
            ..|::.:..|||......|::.::.::.|::..|||||||||:||||..||:|.: |:||:|:||
Zfish   244 PEIQEARLRLPVLAEEQIIMEAVKDHECVVLCGETGSGKTTQVPQFLYEAGFASSGGIIGVTEPR 308

  Fly   123 RVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIIL 187
            |||||:::.|||.|:|.:.| .|.|.:|:|...:..|||:.:||||||:|..:|.||.||||||:
Zfish   309 RVAAISMSHRVATEMNLSSG-VVSYQIRYEGNVTENTKIKVMTDGVLLKEIQRDFLLQKYSVIII 372

  Fly   188 DEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFNCKGMY--------L 244
            ||||||:|..|:|.|::......|.|:.|. :|:::.|||:.::.|...   |.::        :
Zfish   373 DEAHERSVYTDILIGLLSRIVPLRNKKGLP-MKLIIMSATLRVEDFTEN---KRLFSSPPPVIKV 433

  Fly   245 EGRTYPVRVMHTKE-EHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQ----- 303
            |.|.:.|.|...|. ..:||.......:..|||..|.. .:|:|||||.|:.|:.:::|:
Zfish   434 EARQFAVTVHFNKRTPMDDYTGETFRKICKIHRMLPPG-GILVFLTGQAEVHSVCRRLRKAFPYK 497

  Fly   304 ---------------------------LAKI------------------------DTTGT----- 312
                                       |.:|                        |..|:
Zfish   498 PNREHTDMMETEEDLKKSKRAKKKNVSLPRINLDNYSALPVDEGDEDRQAGIDEDDGEGSDLELE 562

  Fly   313 ------TD----------LRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRC 361
                  ||          |.|..||:.|:..:|.:.|.|.||..|..::|||:||||:|||||:.
Zfish   563 LGDHPDTDHEEKADPSIPLYVLPLYSLLAPEQQAKVFRPPPAGSRLCVVATNVAETSLTIPGIKY 627

  Fly   362 VIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPE 426
            |:|||.||::.::.|.|:...|...||:|.|.||||||||...|.|||.|:.|....|:..::.|
Zfish   628 VVDCGRVKKRFYDRVTGVSSFKVTWISQASANQRAGRAGRTEPGHCYRLYSSAVFGDFSLFSEAE 692

  Fly   427 ILRTNPTSMVLQLLALDID-CNNFDFLDPPLEDGLRSAYKSLDALGAI-------------KTGD 477
            |.|.....:|||:..|:|: ..||.|..||..:.|.:|.:.|.:|||:             |...
Zfish   693 ITRRPVEDLVLQMKDLNIEKVVNFPFPTPPSSEALIAAEELLISLGALEKPARHGRLSEMEKARL 757

  Fly   478 DSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFV-------SNSEKNEM 535
            ...|:||||.|..:|:.|:|:|:|......|||:.|:::||.::...:|.       |..|..:|
Zfish   758 SCPISPLGRAMAAFPVAPRYAKMLALGRQQGCMQYIITIVSAMTVREIFEDYDRPAGSEEENVKM 822

  Fly   536 AALAHAKFQSKH-----------GDHLTLLNVFNGFLKSEKPKMWCHDNYLNLRSLTYARNVRRQ 589
            :.......|.:.           ||.:.||........:.....:|.:|.|..:::...|.:|.|
Zfish   823 SGKKARSVQMRRLWAGQGASLLLGDLMVLLGAVGACEFAGLTPQFCEENGLRFKAMLEIRRLRGQ 887

  Fly   590 L----------REISEHLHLALNSSDDIEMLKKCILNGFFENIAVLQRDGFYITASGNIRSK--- 641
            |          .::.....:|..:...:..|::.:|.|..::||  :|    :.|...:..|
Zfish   888 LTNAVNAVCADADVYVDNKMAPPTEAQVLCLRQIVLAGLGDHIA--RR----VQAEELLDPKWRN 946

  Fly   642 ------------IHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP 686
                        |||||.|| |..|.::::.||::|.:.::|.|..:..:||.:::|
Zfish   947 AYKTPLLDDPVFIHPSSALH-KTLPEFVVYQEIMETTKMYMRGVCAVQDDWIPKLLP 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
dhx37	XP_005172500.1	HrpA	200..1007	CDD:224557	244/816 (30%)
		DEXDc	272..412	CDD:238005	73/141 (52%)
		HELICc	583..667	CDD:197757	41/83 (49%)
		HA2	730..781	CDD:282288	16/50 (32%)
		HA2	761..>813	CDD:214852	18/51 (35%)
		OB_NTP_bind	<918..1004	CDD:285018	25/92 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820