DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5731 and gana-1

DIOPT Version :9

Sequence 1:	NP_609354.1	Gene:	CG5731 / 34355	FlyBaseID:	FBgn0032192	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_506031.1	Gene:	gana-1 / 179660	WormBaseID:	WBGene00011095	Length:	451	Species:	Caenorhabditis elegans

Alignment Length:	406	Identity:	191/406 - (47%)
Similarity:	255/406 - (62%)	Gaps:	10/406 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 CLDNGLAKTPPMGWLSWERFRCNTDCVNDPDNCISEQLFQTMTDIVVADGYASVGYEYINIDDCW 81
            ||||||.:||||||:||..|.|..|||..|..||:|||::.|.|.:|:.||..|||:.::|||||
Worm    15 CLDNGLGRTPPMGWMSWTAFYCEIDCVKHPTGCINEQLYKDMADQLVSGGYDKVGYKSVHIDDCW 79

  Fly    82 LEKHRSHDGKLVADRKRFPNGIKALSDYIHSRGLKFGIYEDYGNYTCAGYPGIIGYEEKDALQFA 146
            .|..|...|.|||::.|||:|:|||:.|:|.||||||||||||..||.||||...:|:.||..||
Worm    80 SEMERDSHGILVANKTRFPSGMKALAKYMHDRGLKFGIYEDYGTKTCGGYPGSYKHEKVDAQTFA 144

  Fly   147 DWNVDYVKLDGCYALPYDMDHGYSTFGRLLNSTGKSMVYSCSWPVYQIYAGIQPNYSAIQTHCNL 211
            .|:|||:|||||......|..||..|.:.||.||:.::||||||.|.|......||:.|..:||.
Worm   145 AWDVDYLKLDGCNIDQAMMPIGYPLFEKELNETGRPIMYSCSWPAYLIDHPELVNYNLIGKYCNT 209

  Fly   212 WRNYDDIQDSWASVENIIDYYGNNQDVIAPNAGPGHWNDPDMLIIGNFGLSYEQAKTQFAIWSIL 276
            |||:|||..||.|:.:||.||...||...|..|||.|:|||||:|||.|::.:.:.:||.:|.|.
Worm   210 WRNFDDINSSWKSIISIISYYDKMQDKHIPTHGPGKWHDPDMLVIGNKGITLDMSISQFTVWCIW 274

  Fly   277 AAPLLMSVDLRTIRPQFKHILQNRKIIAVDQDPLGIQGRRIYKHKGIEIWSRPIGPLYQNFYSYA 341
            :|||:||.|||.|...||.:|:|::.|.::||||||.||.|.....|.::.:.|.|...:..|:|
Worm   275 SAPLIMSNDLRIIGDSFKDVLKNKEAIKINQDPLGIMGRLIKNSTDIGVYVKQITPSKGDKKSFA 339

  Fly   342 IAFVNRRTDGTPSDISVTLKELGLINFSGYRVEDLYENVDYGVLYPNTKIKVKVNPSGVVML--- 403
            .|::||........|.:.|..:||.:.:||.|.|::.:||.|:|.....|.|.:.|:|.|..
Worm   340 FAYLNRNEKEGYKRIEIQLASIGLTDPAGYYVHDIWSHVDLGLLRSGDSIVVSIAPAGSVFFRAD 404

  Fly   404 -------KGEVQYPVD 412
                   ||:.:|..|
Worm   405 LASLHQPKGKRRYKFD 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5731	NP_609354.1	AmyAc_family	25..399	CDD:298606	179/373 (48%)
gana-1	NP_506031.1	AmyAc_family	23..397	CDD:298606	179/373 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167832
Domainoid	1	1.000	328	1.000	Domainoid score	I629
eggNOG	1	0.900	-	-		E1_KOG2366
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H221
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1120
Isobase	1	0.950	-	0.930827	Normalized mean entropy	S1639
OMA	1	1.010	-	-		QHG62673
OrthoDB	1	1.010	-	-		D266390at33208
OrthoFinder	1	1.000	-	-		FOG0001285
OrthoInspector	1	1.000	-	-		otm14536
orthoMCL	1	0.900	-	-		OOG6_101043
Panther	1	1.100	-	-	O	PTHR11452
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R31
SonicParanoid	1	1.000	-	-		X887
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750