DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx17 and SNX27

DIOPT Version :9

Sequence 1:	NP_609353.1	Gene:	Snx17 / 34354	FlyBaseID:	FBgn0032191	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001317652.1	Gene:	SNX27 / 81609	HGNCID:	20073	Length:	541	Species:	Homo sapiens

Alignment Length:	388	Identity:	87/388 - (22%)
Similarity:	154/388 - (39%)	Gaps:	63/388 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YTAYNIHINGIHHCVLRYKQLHSLNDQLRRHCVGVPLPPFPPKRLLPLTNGQLEARRSSLEQYLQ 86
            :..||:::.|...|..||::...|:..|:|.......|..|.|....|:..||:|||..||:||:
Human   180 FVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLE 244

  Fly    87 AVGQDNRLARSAHLQQFLQRA----------QLDTALAEGQVATDCEEQQLEVQVYTNPAGERIL 141
            .|.....:..|..:|:||..:          :|..||.:|...|        |:|..|...:::
Human   245 KVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVT--------VRVKKNSTTDQV- 300

  Fly   142 VNCSVQQNASALLKSVCRELQLPDELVRFFCLFLVRRQRKSGELHLVRRLMDFESPYITRLHVQ- 205
                        .:::..::.:....|.:|.||.|...      ..||:|...|.|:  :|::|
Human   301 ------------YQAIAAKVGMDSTTVNYFALFEVISH------SFVRKLAPNEFPH--KLYIQN 345

  Fly   206 -------PCELLLRTCYWDSSRDAKLTGSKVALNLLYNQTVADVNREWVVICTPGEGRQLNSLQM 263
                   .| |.:|...:.:..:..|..:.:|:...::|.|.||.:.:  |....:..||..|..
Human   346 YTSAVPGTC-LTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDVKKGY--IKAEEKSYQLQKLYE 407

  Fly   264 QGRAREYMDLVRQLPSYGCLQFDEAQVD-YPEPDTMALISIGNKELALRTARG-VKIYETKFRVT 326
            |.:...|::::|....|..:.|.....| ..:...:..|||.:.:|...|..| ::.....|...
Human   408 QRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWD 472

  Fly   327 RMRSWRVSVTHITLESRLEPTHLQLAFEYLIGKQTLRWITINSDQAMLMSVCLQAMVDELLQR 389
            .|:.|..           :...:...|||..|::..||:.|.:.....|..|.:.:..||..|
Human   473 EMQRWDT-----------DEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWR 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx17	NP_609353.1	PX_SNX17_31	7..108	CDD:132795	27/95 (28%)
Snx17	NP_609353.1	FERM-like_C_SNX17	280..391	CDD:270145	24/112 (21%)
SNX27	NP_001317652.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		PDZ_signaling	41..133	CDD:238492
		PX_SNX27	160..265	CDD:132796	27/84 (32%)
		FERM_F1_SNX27	273..365	CDD:340475	23/121 (19%)
		FERM-like region F1	273..362		23/118 (19%)
		FERM-like region F2	373..421		12/49 (24%)
		FERM-like_C_SNX27	425..526	CDD:270146	23/111 (21%)
		FERM-like region F3	425..525		23/111 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3784
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810