DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx17 and Snx31

DIOPT Version :9

Sequence 1:	NP_609353.1	Gene:	Snx17 / 34354	FlyBaseID:	FBgn0032191	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001333951.1	Gene:	Snx31 / 66696	MGIID:	1913946	Length:	439	Species:	Mus musculus

Alignment Length:	427	Identity:	138/427 - (32%)
Similarity:	220/427 - (51%)	Gaps:	35/427 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RMHFSIPDTQE----LGSSPTYTAYNIHINGIHHCVLRYKQLHSLNDQLRRHCVGVPLPPFPPKR 65
            :|||.||.:|:    ||.  .|..|:::::|...|.:||.|||..::|||| ..|..|||||||.
Mouse     2 KMHFCIPVSQQRPDALGG--RYVLYSVYLDGFLFCKVRYSQLHRWDEQLRR-VFGNCLPPFPPKY 63

  Fly    66 LLPLTNGQLEARRSSLEQYLQAVGQDNRLARSAHLQQFLQRAQLDTALAEGQVATDCEEQQLEVQ 130
            .|.:|....|.||..||:|||.|..|.|:.||....:||...||.|        .:...|.:|:.
Mouse    64 YLAMTTAMAEERRDQLERYLQNVTADPRVTRSDVFTEFLTLVQLHT--------LNITIQNVELA 120

  Fly   131 VYTNPAGERILVNCSVQQNASALLKSVCRELQLPDELVRFFCLFLVRRQRKSGELHLVRRLMDFE 195
            |:. |.|..|.|.......|..:|:.:..:|.|..:||.:|.|||: :....|:|.:|::|.|||
Mouse   121 VFL-PDGRSIKVEGLTSDTAERVLEVMAHKLGLQPDLVGYFGLFLI-QCFPEGKLSVVKKLADFE 183

  Fly   196 SPY--ITRLHVQPCELLLRTCYWDSSRDAKLTGSKVALNLLYNQTVADVNREWVVICTPGEGRQL 258
            .||  :....::.|::.||..|.|.:.|:.|...:.|.:|||.|.|.|:.:||:. .|..:..:|
Mouse   184 LPYTSLQSSEMENCKIGLRKWYLDPALDSMLMDCRAAGDLLYMQAVQDIEKEWMK-PTQAQREEL 247

  Fly   259 NSLQMQGRAREYMDLVRQLPSYGCLQFDEAQVDYPEPDTMALISIGNKELA-LRTARGVKIYETK 322
            .:||.:....::::|.:::..||.:|.|....::|||...|.:||||.|:: ..|....:|.:..
Mouse   248 KALQKKENQTKFLELSQEVRHYGYVQLDPCTCNHPEPGCGAQLSIGNNEISCCITLPNGQIQDIA 312

  Fly   323 FRVTRMRSWRVSVTHITLES----RLEPTHLQLAFEYLIGKQTLRWITINSDQAMLMSVCLQAMV 383
            |:::|::.|:|:.....|::    |....:|:|.|:| ......:|..|.:.||..:|.||:.|:
Mouse   313 FQMSRVKCWQVTFLGTLLDTDGPQRTLNQNLELRFQY-SEDSCQQWFVIYTKQAFFLSSCLKKMI 376

  Fly   384 DELLQRGAGSGKDQNSDEEQ----EQNAVTSSSSTPS 416
            .|.:.:     ..:.|.|.|    ||.......|.||
Mouse   377 SERMTK-----LTEQSPEMQIEVPEQGRSKKHPSQPS 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx17	NP_609353.1	PX_SNX17_31	7..108	CDD:132795	45/104 (43%)
Snx17	NP_609353.1	FERM-like_C_SNX17	280..391	CDD:270145	34/115 (30%)
Snx31	NP_001333951.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..409		8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6365
eggNOG	1	0.900	-	-		E1_KOG3784
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D263172at33208
OrthoFinder	1	1.000	-	-		FOG0003603
OrthoInspector	1	1.000	-	-		otm43839
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12431
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2951
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.950