DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx17 and snx17

DIOPT Version :9

Sequence 1:	NP_609353.1	Gene:	Snx17 / 34354	FlyBaseID:	FBgn0032191	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_009292899.1	Gene:	snx17 / 568263	ZFINID:	ZDB-GENE-030131-9475	Length:	473	Species:	Danio rerio

Alignment Length:	517	Identity:	196/517 - (37%)
Similarity:	282/517 - (54%)	Gaps:	76/517 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MHFSIPDTQ----ELGSSPTYTAYNIHINGIHHCVLRYKQLHSLNDQLRRHCVGVPLPPFPPKRL 66
            ||||||:|:    |.|||  |.|||||:||:.||.:||.||..|::|:::......:|.||||::
Zfish     1 MHFSIPETEVRSDENGSS--YVAYNIHVNGVLHCRVRYSQLLGLHEQIKKEYGNNVVPAFPPKKI 63

  Fly    67 LPLTNGQLEARRSSLEQYLQAVGQDNRLARSAHLQQFLQRAQLDTALAEGQVATDCEEQQLEVQV 131
            ..||..:::.||..||:|:|||.||..|..|.....||::||.:|.    |:.|  ||.|||:.:
Zfish    64 FTLTPAEVDQRREQLEKYMQAVRQDPILGSSEMFNSFLRKAQQETQ----QIPT--EEVQLEIYL 122

  Fly   132 YTNPAGERILVNCSVQQNASALLKSVCRELQLPDELVRFFCLFLVRRQRKSGELHLVRRLMDFES 196
            ..   |:::.||.........:|::|..:|.||||||.:|.|||| ::|..|....||:|.:||.
Zfish   123 SN---GQKVKVNILTSDQTEDVLEAVASKLDLPDELVGYFSLFLV-QERADGSCTYVRKLQEFEL 183

  Fly   197 PY--ITRLHVQPCELLLRTCYWDSSRDAKLTGSKVALNLLYNQTVADVNREWVVICTPGEGRQLN 259
            ||  ||.||.....::||..|||::.|:.:...:|.|||||.|||:|::|.|::: ...:.|||.
Zfish   184 PYVSITSLHSSDYRIILRKSYWDTAYDSDVMDDRVGLNLLYAQTVSDIDRGWILV-NKEQHRQLK 247

  Fly   260 SLQMQGRAREYMDLVRQLPSYGCLQFDEAQVDYPEPDTMALISIGNKELALRTARGVKI-----Y 319
            |||.:|..:|::.|.:.|..||.::||....|:||.....::..||.||...    ||:     .
Zfish   248 SLQEKGSKKEFIRLAQTLKYYGYIKFDPCITDFPEKGCHVIVGAGNNELNFH----VKLPNEQMK 308

  Fly   320 ETKFRVTRMRSWRVSVTHITL---------ESRLEPTHLQLAFEYLIGKQTLRWITINSDQAMLM 375
            |..|:|||||.|||:.:.:.:         .|:.: ..|:||||||:.|..|:|:||.|.||::|
Zfish   309 EGSFKVTRMRCWRVTSSQVPVANGTANPSSSSKCD-VKLELAFEYLMSKDRLQWVTITSQQAIMM 372

  Fly   376 SVCLQAMVDELLQRGAG------------SGKDQNSDEEQEQNAVTSSSSTPSSTCSTSTWASST 428
            |:|||:|||||:.:.:|            :|..|.||.:|   ||.|.....|..
Zfish   373 SICLQSMVDELMVKKSGGSIKKQMQKKRLNGSLQRSDSQQ---AVKSPPILDSPD---------- 424

  Fly   429 CSTSTAPTTPPVRFLSEDSAPRSKPRLTTSRTFGAVFFRNDVVDNGARVANGAFEGIGDDDL 490
                  |....|..||...:..|...|::|.:.|      |:..|... .|.||||||||||
Zfish   425 ------PNREQVVKLSTKLSSVSLRGLSSSNSAG------DISGNDFH-GNYAFEGIGDDDL 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx17	NP_609353.1	PX_SNX17_31	7..108	CDD:132795	47/104 (45%)
Snx17	NP_609353.1	FERM-like_C_SNX17	280..391	CDD:270145	49/124 (40%)
snx17	XP_009292899.1	PX_SNX17_31	2..105	CDD:132795	47/104 (45%)
		UBQ	115..>185	CDD:294102	28/73 (38%)
		FERM-like_C_SNX17	268..388	CDD:270145	49/124 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579556
Domainoid	1	1.000	114	1.000	Domainoid score	I6053
eggNOG	1	0.900	-	-		E1_KOG3784
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8838
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2686
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D263172at33208
OrthoFinder	1	1.000	-	-		FOG0003603
OrthoInspector	1	1.000	-	-		oto40154
orthoMCL	1	0.900	-	-		OOG6_107920
Panther	1	1.100	-	-	O	PTHR12431
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2951
SonicParanoid	1	1.000	-	-		X5262
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790