DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx17 and snx27a

DIOPT Version :9

Sequence 1:	NP_609353.1	Gene:	Snx17 / 34354	FlyBaseID:	FBgn0032191	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001038565.1	Gene:	snx27a / 566205	ZFINID:	ZDB-GENE-060503-371	Length:	567	Species:	Danio rerio

Alignment Length:	471	Identity:	104/471 - (22%)
Similarity:	177/471 - (37%)	Gaps:	111/471 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SIP-------DTQELG----------------SSPTY----------TAYNIHINGIHHCVLRYK 40
            |||       ||.|.|                |.|||          ..||::::|...|..||:
Zfish   137 SIPAQEADGLDTSEEGAVQPNYDYSDKQAVPISVPTYKHVEQHSEKFVVYNVYMSGRQLCSKRYR 201

  Fly    41 QLHSLNDQLRRHCVGVPLPPFPPKRLLPLTNGQLEARRSSLEQYLQAVGQDNRLARSAHLQQFLQ 105
            :...|:..|:|.......|..|.|....|:..||:|||..||:|::.|.....:..|..:|:||.
Zfish   202 EFAILHQNLKREFSNYTFPKLPGKWPFSLSEQQLDARRRGLEEYMERVCSVRIIGESDIMQEFLS 266

  Fly   106 RA----------QLDTALAEGQVATDCEEQQLEVQVYTNPAGERILVNCSVQQNASALLKSVCRE 160
            .:          :|..||.:...|:        |:|..|...:::.....|:....:::.|
Zfish   267 ESNENHNGITDVELRIALPDKTTAS--------VRVQKNSTTDQVYQALVVKVGMDSMMAS---- 319

  Fly   161 LQLPDELVRFFCLFLVRRQRKSGELHLVRRLMDFESPYITRLHVQ--------PCELLLRTCYWD 217
                     :|.||.|...      ..||:|...|.|:  :|:||        .| |.:|...:.
Zfish   320 ---------YFALFEVINH------SFVRKLAPNEFPH--KLYVQNYTSAVPGTC-LTMRKWLFS 366

  Fly   218 SSRDAKLTGSKVALNLLYNQTVADVNREWVVICTPGEGRQLNSLQMQGRAREYMDLVRQLPSYGC 282
            :..:..|..:.:||:..::|...||.:.:  |....:..||..|..|.:...|:.|:|....|..
Zfish   367 TQEEDLLRDNPLALHYCFHQAQDDVKKGF--IKAEDKAYQLQKLAEQRKMTTYLSLLRSCEGYNE 429

  Fly   283 LQFDEAQVD-YPEPDTMALISIGNKELALRTARG-VKIYETKFRVTRMRSWRVSVTHITLESRLE 345
            :.|.....| ..:...:..:|:.:.:|...|..| ::.....|..:.|:.|..           :
Zfish   430 VTFPHCPCDSRRKGHVITAVSMKHFKLHACTEDGTLENQVIMFEWSEMQRWDT-----------D 483

  Fly   346 PTHLQLAFEYLIGKQTLRWITINSDQAMLMSVCLQAMVDELLQRGAGSGKDQNSDEEQEQNAVTS 410
            ...:...|||:.|::..||:.|.:.....|..|.:.:..||..|           :|.|:.|
Zfish   484 EEGMAFCFEYVRGEKKPRWVKIFTPYFNYMHECFERIFCELKWR-----------KEVEEEA--- 534

  Fly   411 SSSTPSSTCSTSTWAS 426
             |...:..||.:.:.|
Zfish   535 -SDKGNKNCSNNEYLS 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx17	NP_609353.1	PX_SNX17_31	7..108	CDD:132795	37/141 (26%)
Snx17	NP_609353.1	FERM-like_C_SNX17	280..391	CDD:270145	22/112 (20%)
snx27a	NP_001038565.1	PDZ_signaling	44..136	CDD:238492
		PX_SNX27	163..268	CDD:132796	30/104 (29%)
		SNX27_RA	277..363	CDD:176372	24/115 (21%)
		FERM-like_C_SNX27	428..529	CDD:270146	21/122 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910