DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx17 and Snx17

DIOPT Version :9

Sequence 1:	NP_609353.1	Gene:	Snx17 / 34354	FlyBaseID:	FBgn0032191	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001011981.1	Gene:	Snx17 / 298836	RGDID:	1306424	Length:	470	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	203/516 - (39%)
Similarity:	286/516 - (55%)	Gaps:	77/516 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MHFSIPDTQ----ELGSSPTYTAYNIHINGIHHCVLRYKQLHSLNDQLRRHCVGVPLPPFPPKRL 66
            ||||||:|:    :.|.| ||.|||||:||:.||.:||.||..|::|||:......||.||||:|
  Rat     1 MHFSIPETESRSGDSGGS-TYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKL 64

  Fly    67 LPLTNGQLEARRSSLEQYLQAVGQDNRLARSAHLQQFLQRAQLDTALAEGQVATDCEEQQLEVQV 131
            ..||..::|.||..||:|:|||.||..|..|.....||:|||.:|.    ||.|  ||..|||.:
  Rat    65 FSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQ----QVPT--EEVSLEVLL 123

  Fly   132 YTNPAGERILVNCSVQQNASALLKSVCRELQLPDELVRFFCLFLVRRQRKSGELHLVRRLMDFES 196
               ..|:::|||.........:|::|..:|.|||:|:.:|.|||| |:::.|....||:|.:||.
  Rat   124 ---SDGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLV-REKEDGAFSFVRKLQEFEL 184

  Fly   197 PY--ITRLHVQPCELLLRTCYWDSSRDAKLTGSKVALNLLYNQTVADVNREWVVICTPGEGRQLN 259
            ||  :|.|..|..:::||..||||:.|..:..::|.|||||.|||:|:...|::: |..:.|||.
  Rat   185 PYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILV-TKEQHRQLK 248

  Fly   260 SLQMQGRAREYMDLVRQLPSYGCLQFDEAQVDYPEPDTMALISIGNKELALR-TARGVKIYETKF 323
            |||.:...:|::.|.:.|..||.|:||....|:||.|...::|.||.||:|: ...|.::.|..|
  Rat   249 SLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSF 313

  Fly   324 RVTRMRSWRVSVTHITLESRLEPT--------HLQLAFEYLIGKQTLRWITINSDQAMLMSVCLQ 380
            ||||||.|||: :.:.|.|....|        .|:||||||:.|..|:|:||.|.||::||:|||
  Rat   314 RVTRMRCWRVT-SSVPLPSGGTSTPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQ 377

  Fly   381 AMVDELLQRGAG-----------SGKDQNSDEEQEQNAVTSSSSTPSSTCSTSTWASSTCSTSTA 434
            :|||||:.:.:|           .|..:.||.:|                              |
  Rat   378 SMVDELMVKKSGGSIRKMLRRRVGGNLRRSDSQQ------------------------------A 412

  Fly   435 PTTPPVRFLSEDSAPRSKPRLTTSRTFGAVFFR---NDVVDNGARVANG--AFEGIGDDDL 490
            ..:||: ..|.|::..|..:|  |....||..|   :...|..|...:|  |||||||:||
  Rat   413 VKSPPL-LESPDASRESMVKL--SSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx17	NP_609353.1	PX_SNX17_31	7..108	CDD:132795	52/104 (50%)
Snx17	NP_609353.1	FERM-like_C_SNX17	280..391	CDD:270145	55/119 (46%)
Snx17	NP_001011981.1	PX_SNX17_31	2..106	CDD:132795	54/107 (50%)
		FERM-like. /evidence=ECO:0000250	115..432		123/338 (36%)
		FERM_F1_SNX17	115..207	CDD:340538	34/93 (37%)
		FERM-like_C_SNX17	269..388	CDD:270145	57/138 (41%)
		PTB-like F3 module. /evidence=ECO:0000250	270..432		62/181 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..425		0/23 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6108
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8838
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2578
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D263172at33208
OrthoFinder	1	1.000	-	-		FOG0003603
OrthoInspector	1	1.000	-	-		oto97929
orthoMCL	1	0.900	-	-		OOG6_107920
Panther	1	1.100	-	-	O	PTHR12431
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5262
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.970