Protein Alignment Sur and ABCC10

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_016866934.1
• Gene: ABCC10 / 89845
• HGNCID: 52
• Length: 1558
• Species: Homo sapiens
• Alignment Length: 2061
• Identity: 444/2061 - (21%)
• Similarity: 708/2061 - (34%)
• Gaps: 855/2061 - (41%)

  Fly   227 TFYSKSCFWWLTPLLWLG----YKEPLELEDLGQM--KLEDS--ARSHYDHFLYIYTEKKKKSNS 283
            ::.|:..:.||.|||..|    .::|   :|:.::  :|:.:  ||....|:           ..
Human   270 SWLSRFSYAWLAPLLARGACGELRQP---QDICRLPHRLQPTYLARVFQAHW-----------QE 320

  Fly   284 SPSLW--------YCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQ---------LY 331
            ...||        .||:       || |:|||.|.:....|||.:..:|.::|:         ||
Human   321 GARLWRALYGAFGRCYL-------AL-GLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLY 377

  Fly   332 AQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLA 396
            |..                |:...:||......:|..:.||.:
Human   378 ALG----------------LAGGAVLGAVLQNQYGYEVYKVTL---------------------- 404

  Fly   397 AITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKN 461
                    ||...:||            ::|.|:|.|
Human   405 --------QARGAVLN------------ILYCKALQL---------------------------- 421

  Fly   462 DDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLG 526
                       .||.|    ..|...|.:..|:..::.|....|.||.:|.::|:.:||||..:|
Human   422 -----------GPSRP----PTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVG 471

  Fly   527 ISAVIGSIACIVIMTPLQFFIG-NAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLK 590
            : |.:|.:...:::.|:...|. ..|:.|.|::. :.|.|:|.:.:.|.||:|||...|::....
Human   472 V-AFVGGLILALLLVPVNKVIATRIMASNQEMLQ-HKDARVKLVTELLSGIRVIKFCGWEQALGA 534

  Fly   591 KIQEARRKEL------KYLNKDATF-WTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRL 648
            :::..|.:||      |||:....: |..:.|:..| .:.||:|.:|     |:     |.|:::
Human   535 RVEACRARELGRLRVIKYLDAACVYLWAALPVVISI-VIFITYVLMG-----HQ-----LTATKV 588

  Fly   649 FSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLD 713
            |::|||.:.|.:||..||..:..::.|:||..|::.||
Human   589 FTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFL--------------------------- 626

  Fly   714 MYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNK 778
                    ::.....||....:..||.  :|...|..:..|        ||   ||||.||
Human   627 --------DLPNHNPQAYYSPDCGRLG--AQIKWLLCSDPP--------AE---PSTVLEL---- 666

  Fly   779 LVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGL 843
                                                                         :..|
Human   667 -------------------------------------------------------------HGAL 670

  Fly   844 FTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCT-IS 907
            |:|.|....  ::..:..:.|.||.|..:|||.|.||:|||:|:..|:..|.|::....... ..
Human   671 FSWDPVGTS--LETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFG 733

  Fly   908 YVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQ 972
            ..:|:||:...|||:|||||::|..:.|..|||||||..|:.::|.||.:.:||:|:.:|||||.
Human   734 LATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRA 798

  Fly   973 RIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLI 1037
            |||:|||:|....:.::|||||::|.:|..|:...||..||..:.|  :|.|.:...::.|:.::
Human   799 RIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTR--LLCTHRTEYLERADAVL 861

  Fly  1038 AIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGL 1102
            .::.||:...|..::|
Human   862 LMEAGRLIRAGPPSEI------------------------------------------------- 877

  Fly  1103 QRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIY 1167
                                                                             
Human   878 ----------------------------------------------------------------- 877

  Fly  1168 GSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVL 1232
                      ||
Human   878 ----------LP----------------------------------------------------- 879

  Fly  1233 SRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKK 1297
                                 |..|.|    ::|
Human   880 ---------------------LVQAVP----KAW------------------------------- 888

  Fly  1298 SEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFP 1362
            :|..:.|:                                     |||
Human   889 AENGQESD-------------------------------------SAT----------------- 899

  Fly  1363 ASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHV 1427
                        .||.:.|:|                             |....::||
Human   900 ------------AQSVQNPEK-----------------------------TKEGLEEEQ------ 917

  Fly  1428 LAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDI 1492
                 ..||       ||..:..:|.|.::..:|..|.:|.|..:......:.|:.|..|...|.
Human   918 -----STSG-------RLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADW 970

  Fly  1493 WLQQW------------SNVHGRVASKG--------------HVVLHPSEQ-----DHEVTYYFR 1526
            ||..|            :......||.|              ::.:.|..:     ..::.:|..
Human   971 WLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLT 1035

  Fly  1527 MYAAISCV---CIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSND 1588
            :||.|:.|   |.::..|...||.   ..|...||.:||..:|...:.||..||.|||:||||:|
Human  1036 VYATIAGVNSLCTLLRAVLFAAGT---LQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSD 1097

  Fly  1589 MAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIE 1653
            :|..|..:......||......|..:.:..:..||:|:|..|:...||.:|:.||.|:|||:|:.
Human  1098 VACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLG 1162

  Fly  1654 NATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGC 1718
            :.|.||:.|||::|:.|::.:||.....||.|...:.||.|.......:.:.:||.:.|..:|
Human  1163 SLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMG-- 1225

  Fly  1719 IVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLV 1783
               .|.|:|:  |.::..:|.:...                         :|.||||:::|.|.:
Human  1226 ---AAVVSAI--AGIALVQHQQGLA-------------------------NPGLVGLSLSYALSL 1260

  Fly  1784 PIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDR 1848
            ...|:.:|......|....||||:..|.                  .||..||
Human  1261 TGLLSGLVSSFTQTEAMLVSVERLEEYT------------------CDLPQEP------------ 1295

  Fly  1849 SSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGD 1913
                                   .|...::|                               ||
Human  1296 -----------------------QGQPLQLG-------------------------------TG- 1305

  Fly  1914 GNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQ 1978
                                                                          |..
Human  1306 --------------------------------------------------------------WLT 1308

  Fly  1979 RGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYID 2043
            :|.:.|.:|.|.|.....|.:..:|..:..|:::||.||||||||||.|.||.:|:.:.|.:.:|
Human  1309 QGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLD 1373

  Fly  2044 DVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVN--GHLP 2106
            .||..::...:||::|:||||:..||:.|:||||||.|..:|..||..|:...|.|.:.  |
Human  1374 GVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMG--- 1435

  Fly  2107 LGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTI 2171
             |||..:.:||.:||.|.|||||||||:|..:..|.:||||:.:|..|:..|.:.....|..:|:
Human  1436 -GLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTV 1499

  Fly  2172 ITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLE 2217
            :||||||.|||:.||::||..||:||..:|..|:....|:|:.||:
Human  1500 LTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQ 1545

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010