Protein Alignment Sur and VMR1

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_011828.1
• Gene: VMR1 / 856350
• SGDID: S000001027
• Length: 1592
• Species: Saccharomyces cerevisiae
• Alignment Length: 2234
• Identity: 474/2234 - (21%)
• Similarity: 789/2234 - (35%)
• Gaps: 867/2234 - (38%)

  Fly    78 LLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNY-----------LVVIGSG---------ELW 122
            :|.|..||:..|.:...:.:|...|..|.|...::           |.:||..         ||.
Yeast   102 ILKLRHFDITTIDVKQIDAKNHGGLTFSRPSTSDHLRKSSEIVLMSLQIIGLSFLRVTKINIELT 166

  Fly   123 NALFSTLLTLMLMLYHRMVER--KKAT----VFLYASTAVEALTFALL-----------SNELFE 170
            |...:|||...|:|....:.|  |::|    :...|.|.:...|:..:           .:::|.
Yeast   167 NRDVTTLLLFWLILLSLSILRVYKRSTNLWAICFTAHTTIWISTWIPIRSVYIGNIDDVPSQIFY 231

  Fly   171 LVRYEDFLELQTCLVAMSAMCMVSLA--MLDGLTVYKECYHDDYL-DDYGKIGYKHSMATFYSKS 232
            :..:          |..|.:..:.|.  :.|..::.       |: ||:.....:|..:..   |
Yeast   232 IFEF----------VITSTLQPIKLTSPIKDNSSII-------YVRDDHTSPSREHISSIL---S 276

  Fly   233 CF-W-WLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHF-LYIYTEKKKKSNSSPSLWYCYIKN 294
            |. | |:|..:|...|..::|:|:..:.:||     |..| |..:|.:.|..|:.....:    .
Yeast   277 CITWSWITNFIWEAQKNTIKLKDIWGLSMED-----YSIFILKGFTRRNKHINNLTLALF----E 332

  Fly   295 SWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGT 359
            |::.:.|.|:      |:.|:                            |.:.|:|   ..||..
Yeast   333 SFKTYLLIGM------LWVLV----------------------------NSIVNLL---PTILMK 360

  Fly   360 EFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTG--------I 416
            .|.|:    :|.....||..:        :||:.::...    :.:.:..|.|..|        :
Yeast   361 RFLEI----VDNPNRSSSCMN--------LAWLYIIGMF----ICRLTLAICNSQGQFVSDKICL 409

  Fly   417 RIKTSLQGLIYRKSL---LLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPN 478
            ||:..|.|.||.|.|   |..:             ..|||.||                     :
Yeast   410 RIRAILIGEIYAKGLRRRLFTS-------------PKTSSDSD---------------------S 440

  Fly   479 ISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPL 543
            ||.::|:|.|.::.|:..:.|....::........|.||:.||:..||:||..| |:.|::|.||
Yeast   441 ISANLGTIINLISIDSFKVSELANYLYVTVQAVIMIIVVVGLLFNFLGVSAFAG-ISIILVMFPL 504

  Fly   544 QFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDAT 608
            .|.:.|.:.|..:.....||:|:.::::.|..|:::|..||:...:.:|:..|:|||:.|.|.:.
Yeast   505 NFLLANLLGKFQKQTLKCTDQRISKLNECLQNIRIVKYFAWERNIINEIKSIRQKELRSLLKKSL 569

  Fly   609 FWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIII 673
            .|::.:.|..:...|:|.||..:..::   |..||||...|::|:||..|..||......:..|.
Yeast   570 VWSVTSFLWFVTPTLVTGVTFAICTFV---QHEDLNAPLAFTTLSLFTLLKTPLDQLSNMLSFIN 631

  Fly   674 AARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKR 738
            .::||.:|:..||:                          |.:|::.:.:|:
Yeast   632 QSKVSLKRISDFLR--------------------------MDDTEKYNQLTI------------- 657

  Fly   739 LAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGS 803
                                                                             
Yeast   658 ----------------------------------------------------------------- 657

  Fly   804 VMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTW-QPQSQMPVVQLHVPGIIVPKG 867
                                       .||...:...:...|| :..|.|...:|....|....|
Yeast   658 ---------------------------SPDKNKIEFKNATLTWNENDSDMNAFKLCGLNIKFQIG 695

  Fly   868 KLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHK--------------TCTISYVSQQPWLLND 918
            ||.:::|..||||::||..||.|:.|::|::....              |.:.:|.||..|||||
Yeast   696 KLNLILGSTGSGKSALLLGLLGELNLISGSIIVPSLEPKHDLIPDCEGLTNSFAYCSQSAWLLND 760

  Fly   919 TIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSS 983
            |::.||:|...:...||:.|::||.||.|:|::|.|||:.|||:||.:||||:|||::|||:|||
Yeast   761 TVKNNIIFDNFYNEDRYNKVIDACGLKRDLEILPAGDLTEIGEKGITLSGGQKQRISLARAVYSS 825

  Fly   984 ANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLH-RIKEAEYLIAIKDGRVEAC 1047
            |..|::||.|:::|:.....|:::||...|.| |||.||||..:. .::.|.:.|.:::|:|
Yeast   826 AKHVLLDDCLSAVDSHTAVWIYENCITGPLMK-NRTCILVTHNVSLTLRNAHFAIVLENGKV--- 886

  Fly  1048 GSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDA 1112
                                            :|.|
Yeast   887 --------------------------------KNQG----------------------------- 890

  Fly  1113 NVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVP 1177
                           ::..:||..:.::..|.:|
Yeast   891 ---------------TITELQSKGLFKEKYVQLS------------------------------- 909

  Fly  1178 LPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCS 1242
                                  .|.|.|..:::||..
Yeast   910 ----------------------SRDSINEKNANRLKA---------------------------- 924

  Fly  1243 SYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTS 1307
                              ||
Yeast   925 ------------------PR--------------------------------------------- 926

  Fly  1308 SESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNK 1372
                                                                            |
Yeast   927 ----------------------------------------------------------------K 927

  Fly  1373 NETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGR 1437
            |::|..|...:.:|.|                     ||..:.
Yeast   928 NDSQKIEPVTENINFD---------------------ANFVND---------------------- 949

  Fly  1438 ESMPLARLAIDTERKYGKISDDIYLMYIR-AAGLPIITIFFITALIWQCLRVYTDIWLQQWSN-V 1500
                 .:|..:.|:..|.||.|:|..|:: ..|...:|..|...:..|.|.:....|::.|.| .
Yeast   950 -----GQLIEEEEKSNGAISPDVYKWYLKFFGGFKALTALFALYITAQILFISQSWWIRHWVNDT 1009

  Fly  1501 HGRVASKGHV--------VLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNL 1557
            :.|:.:.|..        :...|:..|...||..:|..|..:..::....|.....:|..|.|.:
Yeast  1010 NVRINAPGFAMDTLPLKGMTDSSKNKHNAFYYLTVYFLIGIIQAMLGGFKTMMTFLSGMRASRKI 1074

  Fly  1558 HDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCL----SAILINV 1618
            .:.||..:||..:.||.|||:|||:||||.|:..:|:::..    .|:.|:.||    |.|.:..
Yeast  1075 FNNLLDLVLHAQIRFFDVTPVGRIMNRFSKDIEGVDQELIP----YLEVTIFCLIQCASIIFLIT 1135

  Fly  1619 TITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRF 1683
            .|||..|.:.:.:...|:.:.|:|..::|||:|:::.|.||:..|.|||:.||.|||||..:.||
Yeast  1136 VITPRFLTVAVIVFVLYFFVGKWYLTASRELKRLDSITKSPIFQHFSETLVGVCTIRAFGDERRF 1200

  Fly  1684 TEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVA-TVTALTAASVSCRRHYEATTSPSA 1747
            ......:::.|..|:..|:.:.:|....:|.:|..||..: :...|..|::
Yeast  1201 ILENMNKIDQNNRAFFYLSVTVKWFSFRVDMIGAFIVLASGSFILLNIANI-------------- 1251

  Fly  1748 SASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQ 1812
                                 ...|.|:::.|.:|......|:|:|.:..||...||||:..|:
Yeast  1252 ---------------------DSGLAGISLTYAILFTDGALWLVRLYSTFEMNMNSVERLKEYS- 1294

  Fly  1813 GQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQR 1877
                                                                   .::::.
Yeast  1295 -------------------------------------------------------SIEQEN---- 1300

  Fly  1878 IGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKD 1942
                         ..||:.|
Yeast  1301 -------------YLGHDEG--------------------------------------------- 1307

  Fly  1943 KQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIP 2007
                        :::|.|||            |||:.|:|..:|:||||......||.|::.|:.
Yeast  1308 ------------RILLLNEP------------SWPKDGEIEIENLSLRYAPNLPPVIRNVSFKVD 1348

  Fly  2008 AGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNAT 2072
            ...:|||.||||:|||::..:||.:|:...|.|.||..||.:|....||..::|||||..||..|
Yeast  1349 PQSKIGIVGRTGAGKSTIITALFRLLEPITGCIKIDGQDISKIDLVTLRRSITIIPQDPILFAGT 1413

  Fly  2073 IRENLDPHGYFQDLQLWNCLELAQL------KEFVNG--------HLPLGLDTVICDGGLNLSAG 2123
            |:.|:||:..:.:.:::..|....|      :|.:|.        :..|.|.|.|.:||||||.|
Yeast  1414 IKSNVDPYDEYDEKKIFKALSQVNLISSHEFEEVLNSEERFNSTHNKFLNLHTEIAEGGLNLSQG 1478

  Fly  2124 HRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLI 2188
            .||||.:||::||....::||||||.:|..::..:.......|...||:||||||.:::||||:|
Yeast  1479 ERQLLFIARSLLREPKIILLDEATSSIDYDSDHLIQGIIRSEFNKSTILTIAHRLRSVIDYDRII 1543

  Fly  2189 VLDQGRIVEDGNPRELQQLEGSVF 2212
            |:|.|.:.|...|.||.:.|..:|
Yeast  1544 VMDAGEVKEYDRPSELLKDERGIF 1567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
VMR1	NP_011828.1	MRP_assoc_pro	212..1575	CDD:188098	448/2124 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100