DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and ABCC11

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001357425.1	Gene:	ABCC11 / 85320	HGNCID:	14639	Length:	1384	Species:	Homo sapiens

Alignment Length:	2016	Identity:	421/2016 - (20%)
Similarity:	718/2016 - (35%)	Gaps:	763/2016 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 WLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEK-KKKSNSSPSLWYCYIKNSWQMF 299
            |||||:....:..|:...:..:.:.|::..:......::.|: .::.....|:....::......
Human    99 WLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRL 163

  Fly   300 ALGGILKLAGDLFALIGP-LAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDE 363
            ....:|.:...:.:::|| |.|.||:||.|:           ..||.|..|
Human   164 IFDALLGICFCIASVLGPILIIPKILEYSEE-----------QLGNVVHGV-------------- 203

  Fly   364 VFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNM-TGIRIKTSLQGLIY 427
                                  |.|.|   |..:....:||.:|:.|:|. |.||.:.::....:
Human   204 ----------------------GLCFA---LFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAF 243

  Fly   428 RKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTE 492
            .|.:               |.:|..                 |:.:          |...:..|.
Human   244 EKLI---------------QFKSVI-----------------HITS----------GEAISFFTG 266

  Fly   493 DTRNIMEF-----FLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMS 552
            |...:.|.     .::|..|     .:.:.....|..:|.:|.| :|.|.:::.||..|:.....
Human   267 DVNYLFEGVCYGPLVLITCA-----SLVICSISSYFIIGYTAFI-AILCYLLVFPLAVFMTRMAV 325

  Fly   553 KNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLT 617
            |.....:..:|:|::...:.|..||:||:..|::.|.|.|::.||||.|.|.|..    |:..||
Human   326 KAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCG----LVQSLT 386

  Fly   618 HIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRL 682
            .|...:|..|...|:|.:|...:..|.||..||.||....|.:.:...||.|..:..::.:..|.
Human   387 SITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRF 451

  Fly   683 ERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENR---LNEKRLAQKSQ 744
            ::|.                              .||.....::|.|..::   ..|..|:.:..
Human   452 KKFF------------------------------LQESPVFYVQTLQDPSKALVFEEATLSWQQT 486

  Fly   745 TPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPV 809
            .|.:...:..|.:|                ||                        ....|.||
Human   487 CPGIVNGALELERN----------------GH------------------------ASEGMTRP- 510

  Fly   810 EFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVG 874
                          ||:|   .|::...|:..              :||...::|.||.:..|.|
Human   511 --------------RDAL---GPEEEGNSLGP--------------ELHKINLVVSKGMMLGVCG 544

  Fly   875 KNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVL 939
            ..||||:|||||:|.||.||.|::  ....:::||.||.|:::..||||||.|.::...||..||
Human   545 NTGSGKSSLLSAILEEMHLLEGSV--GVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVL 607

  Fly   940 EACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHI 1004
            ..|:|..|:||:|.||::.|||||:|:||||:|||::|||:||...:.::||||:::|..||:||
Human   608 HCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHI 672

  Fly  1005 FQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIA 1069
            |:.||::.|:  .:|.:|||.||..::....:|.:::|::  |.:....||||.:
Human   673 FEECIKKTLR--GKTVVLVTHQLQYLEFCGQIILLENGKI--CENGTHSELMQKK---------- 723

  Fly  1070 MAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQS 1134
                              |:..:|::.:.|
Human   724 ------------------GKYAQLIQKMHK----------------------------------- 735

  Fly  1135 NVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLG 1199

Human   736 ----------------------------------------------------------------- 735

  Fly  1200 RRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQ 1264
                               .|||       |:|.                   |.|..|.:|:|:
Human   736 -------------------EATS-------DMLQ-------------------DTAKIAEKPKVE 755

  Fly  1265 SWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSM 1329
            |
Human   756 S---------------------------------------------------------------- 756

  Fly  1330 RRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTI 1394
                                              ..|||                    |.|.::
Human   757 ----------------------------------QALAT--------------------SLEESL 767

  Fly  1395 NCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDD 1459
            |                                     |.:|  ::|..:|..:.|.:.|.:|..
Human   768 N-------------------------------------GNAG--NVPEHQLTQEEEMEEGSLSWR 793

  Fly  1460 IYLMYIRAAG---LPIITIFFITALIWQCLRVYTDIWLQQW------------SNVHGRVASKGH 1509
            :|..||:|||   :..|..||:..:::  |.:::..||..|            ||  |.:|..|:
Human   794 VYHHYIQAAGGYMVSCIIFFFVVLIVF--LTIFSFWWLSYWLEQGSGTNSSRESN--GTMADLGN 854

  Fly  1510 VVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQ 1574
            :..:|     ::::|..:|...:.:.|.:.:.|:.........|...||:||...:....:.||.
Human   855 IADNP-----QLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFD 914

  Fly  1575 VTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILV---LTLPICGAYY 1636
            ..|:||::|.|:.|:..:|:.:....::.|..:|:.::.:||...::|:||:   :.:.||..||
Human   915 TIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYY 979

  Fly  1637 LIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRL-EANTIAYAL 1700
            ::   ::.:....:|:||.:.||:.||:..::||:::|..:.:...|.. .|||| :|......|
Human   980 MM---FKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFIS-QFKRLTDAQNNYLLL 1040

  Fly  1701 LNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSE 1765
            ..:|.||:.:.|:.:          |.|...:|:.                  |..:.::.:|..
Human  1041 FLSSTRWMALRLEIM----------TNLVTLAVAL------------------FVAFGISSTPYS 1077

  Fly  1766 LRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDA 1830
            .:.      :|:|..|.:........::..:.|....:||||..|.:...::|..
Human  1078 FKV------MAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPL---------- 1126

  Fly  1831 DLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHE 1895
                                                                           |.
Human  1127 ---------------------------------------------------------------HM 1128

  Fly  1896 NGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPN 1960
            .|.
Human  1129 EGT-------------------------------------------------------------- 1131

  Fly  1961 EPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSL 2025
                      |.|..|||.|:|.|.:..::|......|:..:.|.|...:.:||.||||||||||
Human  1132 ----------SCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSL 1186

  Fly  2026 GLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWN 2090
            |::||.:::...|.|.||.|||..|..::||::||:||||..|.:.|||.||||.....|.|:|:
Human  1187 GMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWD 1251

  Fly  2091 CLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTE 2155
            .||...|.:.:: ..|..|.|.:.:.|.|.|.|.|||||:|||:||.|..:::||||:.:|..|:
Human  1252 ALERTFLTKAIS-KFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETD 1315

  Fly  2156 SALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLEKGA 2220
            :.:.:....||:|.|::.||||:||:|:.|.::|:..|::||...|..|::..||:|..|:....
Human  1316 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATAT 1380

  Fly  2221 S 2221
            |
Human  1381 S 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
ABCC11	NP_001357425.1	PLN03130	85..1373	CDD:215595	418/2006 (21%)
ABCC11	NP_001357425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..523		7/36 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010