Protein Alignment Sur and YCF1

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_010419.3
• Gene: YCF1 / 851713
• SGDID: S000002542
• Length: 1515
• Species: Saccharomyces cerevisiae
• Alignment Length: 2243
• Identity: 514/2243 - (22%)
• Similarity: 836/2243 - (37%)
• Gaps: 815/2243 - (36%)

  Fly    29 CGIDRVRRVFTFFSIFLLLFGLMFVCSRYKKCHKTLLTFHN----GRAAISLLLLALNSFDLARI 89
            |.||.|  :....:||::.||:..:.:..||.|..:....|    .|.|:.||.:|..|  ||.:
Yeast    31 CFIDGV--ILNLSAIFMITFGIRDLVNLCKKKHSGIKYRRNWIIVSRMALVLLEIAFVS--LASL 91

  Fly    90 FLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKA----TVFL 150
            .:..:...|...:.|.:                    ||:|:|.:.|....:|..::    ||.|
Yeast    92 NISKEEAENFTIVSQYA--------------------STMLSLFVALALHWIEYDRSVVANTVLL 136

  Fly   151 YASTAVEALTFALLSNEL----FELVRYEDFLELQT--CLVAMSAMCMVSLAMLDG--------- 200
            :.........||.|.|.|    :|.:.|..    ||  .|.....:...|:.:|:.
Yeast   137 FYWLFETFGNFAKLINILIRHTYEGIWYSG----QTGFILTLFQVITCASILLLEALPKKPLMPH 197

  Fly   201 ------LTVYKECYHDDYLDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQM-- 257
                  ||..|...:|.              |..:|:..|.|::.|:..||::.|...||.::
Yeast   198 QHIHQTLTRRKPNPYDS--------------ANIFSRITFSWMSGLMKTGYEKYLVEADLYKLPR 248

  Fly   258 -----KLEDSARSHYDHFLYIYTEKKKKSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGP 317
                 :|......::::      |.|:|||  |||.:...:.......|....|...|:.|...|
Yeast   249 NFSSEELSQKLEKNWEN------ELKQKSN--PSLSWAICRTFGSKMLLAAFFKAIHDVLAFTQP 305

  Fly   318 LAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDL 382
            ..::.:::::....::..:..:...|.|                    ..:..|:.|
Yeast   306 QLLRILIKFVTDYNSERQDDHSSLQGFE--------------------NNHPQKLPI-------- 342

  Fly   383 LANGWCIAWIVLLAAITQ-GALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAG 446
             ..|:.||:.:.|...|| ..|.|...::.| ||:.||::|..|||:|||:|       |::::|
Yeast   343 -VRGFLIAFAMFLVGFTQTSVLHQYFLNVFN-TGMYIKSALTALIYQKSLVL-------SNEASG 398

  Fly   447 QVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIP 511
                .|||                             |.|.|.|:.|.:.:.:....::..|:.|
Yeast   399 ----LSST-----------------------------GDIVNLMSVDVQKLQDLTQWLNLIWSGP 430

  Fly   512 FKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGI 576
            |:|.:.:|.||..||.|..:| :..:|||.||..|:.....|..:....|.|||.:.|.:.|..|
Yeast   431 FQIIICLYSLYKLLGNSMWVG-VIILVIMMPLNSFLMRIQKKLQKSQMKYKDERTRVISEILNNI 494

  Fly   577 KVIKLNAWDEVFLKKIQEAR-RKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQE 640
            |.:||.||::.:.:|::|.| .||||.|.|...:..:.:...:|...|::..|..|:|:   .::
Yeast   495 KSLKLYAWEKPYREKLEEVRNNKELKNLTKLGCYMAVTSFQFNIVPFLVSCCTFAVFVY---TED 556

  Fly   641 FDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARIL 705
            ..|....:|.:|.||..|:.||:|.|:.:...|.|.||..||..|..:.|:|
Yeast   557 RALTTDLVFPALTLFNLLSFPLMIIPMVLNSFIEASVSIGRLFTFFTNEELQ------------- 608

  Fly   706 SKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPST 770
                                                                          |.:
Yeast   609 --------------------------------------------------------------PDS 611

  Fly   771 VQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDI 835
            ||.|                       ||                             :|...|:
Yeast   612 VQRL-----------------------PK-----------------------------VKNIGDV 624

  Fly   836 AVSI-NDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMF 899
            |::| :|..|.||.:.:..|...:: .....||.||.:|||.|||||:|||.:|.::..:.|...
Yeast   625 AINIGDDATFLWQRKPEYKVALKNI-NFQAKKGNLTCIVGKVGSGKTALLSCMLGDLFRVKGFAT 688

  Fly   900 WHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGI 964
            .|.  :::||||.||::|.|::||||||..:..:.|:..::||||..|:.::..||.:::||:||
Yeast   689 VHG--SVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKACALTIDLAILMDGDKTLVGEKGI 751

  Fly   965 NISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHR 1029
            ::||||:.|:::|||:|:.|:..::|||||::|..|..|:.:|.:........:|.:|.|.::..
Yeast   752 SLSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSA 816

  Fly  1030 IKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKN-DNPSQNPGEKTAGERWKL 1093
            :..|:.:..:.:|.:...|:|.:|                   .|: |:|           .|||
Yeast   817 LSIADSIALLDNGEITQQGTYDEI-------------------TKDADSP-----------LWKL 851

  Fly  1094 LKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSV---SYPI-GNASC 1154
            |.|..|..                             |.:||...:..:.||   |.|: |...
Yeast   852 LNNYGKKN-----------------------------NGKSNEFGDSSESSVRESSIPVEGELE- 886

  Fly  1155 GGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLT 1219
               .||:.....:|:               .|.:.:|.....|||
Yeast   887 ---QLQKLNDLDFGN---------------SDAISLRRASDATLG-------------------- 913

  Fly  1220 ATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASS 1284
                                        |:|.||
Yeast   914 ----------------------------SIDFGD------------------------------- 919

  Fly  1285 PPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSIL 1349
                                        |:::                  .|..|
Yeast   920 ----------------------------DENI------------------AKREH---------- 928

  Fly  1350 SISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTS 1414
                                                                             
Yeast   929 ----------------------------------------------------------------- 928

  Fly  1415 SPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFIT 1479
                                                |:.||:..:|||.|.:|.....:.:|.:.
Yeast   929 ------------------------------------REQGKVKWNIYLEYAKACNPKSVCVFILF 957

  Fly  1480 ALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVST- 1543
            .:|...|.|..::||:.||.|:.|..|      :|:     ...|..:|.|:.....:..|:.|
Yeast   958 IVISMFLSVMGNVWLKHWSEVNSRYGS------NPN-----AARYLAIYFALGIGSALATLIQTI 1011

  Fly  1544 PAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTL 1608
            ....:...:|.:.||:.:..::|...:.||:.||:|||:||||||:..:|..:..|      |:.
Yeast  1012 VLWVFCTIHASKYLHNLMTNSVLRAPMTFFETTPIGRILNRFSNDIYKVDALLGRT------FSQ 1070

  Fly  1609 LCLSAILINVTI-----TPW-ILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSET 1667
            ..::|:.:..||     |.| .:.:.:|:...|...|::|..::|||:|:::.|.||:.||..||
Yeast  1071 FFVNAVKVTFTITVICATTWQFIFIIIPLSVFYIYYQQYYLRTSRELRRLDSITRSPIYSHFQET 1135

  Fly  1668 IQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAAS 1732
            :.|:.|:|.::||.||:.|...|::.|..|:.....::|||...|:.:|..|:       |.||:
Yeast  1136 LGGLATVRGYSQQKRFSHINQCRIDNNMSAFYPSINANRWLAYRLELIGSIII-------LGAAT 1193

  Fly  1733 VSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADM 1797
            :|..|..:.|.                         :..:|||:::|.|.:...|||:|::..::
Yeast  1194 LSVFRLKQGTL-------------------------TAGMVGLSLSYALQITQTLNWIVRMTVEV 1233

  Fly  1798 EMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGA 1862
            |....|||||..|       ||..::|...|
Yeast  1234 ETNIVSVERIKEY-------ADLKSEAPLIV---------------------------------- 1257

  Fly  1863 TTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAG 1927
                                         :||.
Yeast  1258 -----------------------------EGHR-------------------------------- 1261

  Fly  1928 DKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYE 1992
                              ||::                          ||.:|||.|:|.|.||.
Yeast  1262 ------------------PPKE--------------------------WPSQGDIKFNNYSTRYR 1282

  Fly  1993 GQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRT 2057
            .:...|:.::.:.|...:::||.||||:|||||.|:||.:::.:.|:|.||::.|..|...:||.
Yeast  1283 PELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRH 1347

  Fly  2058 RLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSA 2122
            :|||||||..:|..|:|||:||...:.|..:|..|||:.|||.|......|||..:.:||.|||.
Yeast  1348 KLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEGGGNLSV 1412

  Fly  2123 GHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRL 2187
            |.|||||||||:|..|..|||||||:.:|..|:..:.:....||:.|||:||||||.||:|.||:
Yeast  1413 GQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRTILTIAHRLNTIMDSDRI 1477

  Fly  2188 IVLDQGRIVEDGNPRELQQLEGSVFRGL-LEKG 2219
            ||||.|::.|..:|.:|.....|:|..| :|.|
Yeast  1478 IVLDNGKVAEFDSPGQLLSDNKSLFYSLCMEAG 1510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
YCF1	NP_010419.3	MRP_assoc_pro	27..1511	CDD:188098	514/2243 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100