Protein Alignment Sur and ABCC11

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001319112.1
• Gene: ABCC11 / 839922
• AraportID: AT1G30420
• Length: 1495
• Species: Arabidopsis thaliana
• Alignment Length: 2193
• Identity: 471/2193 - (21%)
• Similarity: 786/2193 - (35%)
• Gaps: 866/2193 - (39%)

  Fly    38 FTFFSIFLLLFGLMFVCSRYKKCHKTLLTFHNGRAAISLLLLALNSFDLARIFLPHQNVRNLNRL 102
            |.:|:: |:|.||  ...:|.|..:..:.|    ..:.:|:......||.   ||.:|..|...|
plant   120 FAWFAM-LVLIGL--ETKQYVKEFRWYVRF----GVVYVLVADAVLLDLV---LPLKNSINRTAL 174

  Fly   103 FQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKATVFLYASTAVEALTFALLSNE 167
                     ||.:  |.....|||.    ::|::|...::       ||..       :.:|:||
plant   175 ---------YLCI--SSRCCQALFG----ILLLVYIPELD-------LYPD-------YHILNNE 210

  Fly   168 LFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDDYLDDYGKIGYKHSMATFYSKS 232
            ..:.|.|:                    |:..|:.:..|.|                 |:.:|..
plant   211 SLDNVEYD--------------------ALPGGVNICPERY-----------------ASIFSGI 238

  Fly   233 CFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSPSLWYCYIKNS-- 295
            .|.|:|||:.|||::|:...|:.|:...|...:....|...:||:.::    |..|.....|:
plant   239 YFSWMTPLMQLGYRKPITERDVWQLDQWDQTETLIKRFQRCWTEESRR----PKPWLLRALNNSL 299

  Fly   296 WQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTE 360
            .:.|.||||.|:..||...:||:.:..|::                            |.|.|
plant   300 GRRFWLGGIFKVGHDLSQFVGPVILSHILQ----------------------------SMIEG-- 334

  Fly   361 FDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGAL--SQASTHILNMTGIRIKTSLQ 423
                           ...|.     |:..|:::.. .:|.|.|  ||...|: ...|.|::::|.
plant   335 ---------------DPAWV-----GYVYAFLIFF-GVTFGVLCQSQYFQHV-GRVGFRLRSTLV 377

  Fly   424 GLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITN 488
            ..|:.|||.|                     :::.:||..|                   |.:||
plant   378 AAIFHKSLRL---------------------TNKARKNFAS-------------------GKVTN 402

  Fly   489 HMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSK 553
            .:|.|...:......:|..|:.||:|.|.:.|||..||::::.||: .:.::.|.|..|...|.|
plant   403 MITTDANALQLIAEQLHGLWSAPFRIIVSMVLLYQQLGVASIFGSL-ILFLLIPFQTLIVRKMRK 466

  Fly   554 NAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTH 618
            ..:....:||:|:..|::.|..:.::|..||::.|..:||..|.:||.:..|........:.:.:
plant   467 LTKEGLQWTDKRVGIIYEILASMDIVKCYAWEKSFESRIQGIRNEELSWFRKAQLLSAFNSFILN 531

  Fly   619 IATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLE 683
            ...|::|.|:.||||.|..    ||..:|.|:||:||..|..||...|..:...:.|.||.:|:|
plant   532 STPVVVTLVSFGVYVLLGG----DLTPARAFTSLSLFAVLRSPLSTLPNLISQAVNANVSLQRIE 592

  Fly   684 RFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPEL 748
            ..|.|.|            |||:::
plant   593 ELLLSEE------------RILAQN---------------------------------------- 605

  Fly   749 ATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSV 813
                                                            ||...|:.
plant   606 ------------------------------------------------PPLQPGAP--------- 613

  Fly   814 IRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGS 878
                                  |:||.:|.|:|..::..|.  |....:.:|.|.|..:||..|.
plant   614 ----------------------AISIKNGYFSWDSKTSKPT--LSDINLEIPVGSLVAIVGGTGE 654

  Fly   879 GKTSLLSALLMEMPLLAGNMFWHKTC------TISYVSQQPWLLNDTIRENILFGESFRPKRYDF 937
            |||||:||:|       |.:...:|.      :::||.|..|:.|.|:|||||||..|..:||..
plant   655 GKTSLISAML-------GELSHAETSSVDIRGSVAYVPQVSWIFNATLRENILFGSDFESERYWR 712

  Fly   938 VLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGE 1002
            .::..||:.|::|.|..|.:.|||||:||||||:||:::|||:||::::.|.|||.::||..|..
plant   713 AIDVTALQHDLDLFPGRDRTEIGERGVNISGGQKQRVSMARAVYSNSDIYIFDDPFSALDAHVAH 777

  Fly  1003 HIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAI 1067
            .:|..|::..|:  .:|.:|||.|||.:...:.:|.:.:|.::..|::|::
plant   778 QVFDSCVKHELK--GKTRVLVTNQLHFLPLMDRIILVSEGMIKEEGNFAEL-------------- 826

  Fly  1068 IAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANM 1132
                            .|:.....||::|..|:...:.:
plant   827 ----------------SKSGTLFKKLMENAGKMDATQEV-------------------------- 849

  Fly  1133 QSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHT 1197
                                                                             
plant   850 ----------------------------------------------------------------- 849

  Fly  1198 LGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPR 1262
                   |||..:    :|.|..|     ::.||..||:
plant   850 -------NTNDEN----ISKLGPT-----VTIDVSERSL-------------------------- 872

  Fly  1263 VQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRM 1327
                                                                   ||.||
plant   873 -------------------------------------------------------GSIQQ----- 877

  Fly  1328 SMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKET 1392
                                                                             
plant   878 ----------------------------------------------------------------- 877

  Fly  1393 TINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKIS 1457
                                                    |:.||     :.|....||:.|.||
plant   878 ----------------------------------------GKWGR-----SMLVKQEERETGIIS 897

  Fly  1458 DDIYLMYIRA-AGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEV 1521
            .|:.:.|.:| .||.::.|..:..|..:.|||.:..||..|::             ..:.:.:..
plant   898 WDVVMRYNKAVGGLWVVMILLVCYLTTEVLRVLSSTWLSIWTD-------------QSTPKSYSP 949

  Fly  1522 TYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFS 1586
            .:|..:||.:....:.:...::.....:..:|.:.|||.:|.:||...:.||:..|.||::||||
plant   950 GFYIVVYALLGFGQVAVTFTNSFWLISSSLHAAKRLHDAMLNSILRAPMLFFETNPTGRVINRFS 1014

  Fly  1587 NDMAVIDKKIAATGQRLLQ--FTLLCLSAIL-INVTITPWILVLTLPICGAYYLIQKFYRCSARE 1648
            .|:..||:.:|......:.  :.||...|:: |..||:.|.:   :|:...:|....:|:.::||
plant  1015 KDIGDIDRNVANLMNMFMNQLWQLLSTFALIGIVSTISLWAI---MPLLILFYATYIYYQSTSRE 1076

  Fly  1649 LQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNT-SHRWLGVSL 1712
            ::|:::.|.||:.:...|.:.|:::|||:....|..:|..|.:: |.|.:.|.:| |:|||.:..
plant  1077 VRRLDSVTRSPIYALFGEALNGLSSIRAYKAYDRMAKINGKSMD-NNIRFTLASTSSNRWLTIRS 1140

  Fly  1713 DYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTK--SPSELRPSPSLVGL 1775
            :.|||.:::      |||                         |:||.:  :........|.:||
plant  1141 ESLGGVMIW------LTA-------------------------TFAVLRYGNAENQAVFASTMGL 1174

  Fly  1776 AINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNE 1840
            .::|||.:...|:.|::..:..|....||||:.:|
plant  1175 LLSYTLNITTLLSGVLRQASKAENSLNSVERVGNY------------------------------ 1209

  Fly  1841 DVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKL 1905
                 :|..|::
plant  1210 -----IDLPSEA----------------------------------------------------- 1216

  Fly  1906 NAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQ 1970
                                           |::|::.:
plant  1217 -------------------------------TAIIENNR-------------------------- 1224

  Fly  1971 SVPIS-WPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQ 2034
              |:| ||.||.|.|::|.|||......|:..|:..:...:::|:.||||:||||:..:|:.:::
plant  1225 --PVSGWPSRGSIQFEDVHLRYRPGLPPVLHGLSFFVYPSEKVGVVGRTGAGKSSMLNALYRIVE 1287

  Fly  2035 TTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKE 2099
            ..:|.|.|||.|:.:....:||..||||||...||:.|:|.|:||.....|..||..||.|.:|:
plant  1288 LEKGRILIDDYDVAKFGLTDLRRVLSIIPQSPVLFSGTVRFNIDPFSEHNDADLWEALERAHIKD 1352

  Fly  2100 FVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADL 2164
            .::.: |.|||..:.:||.|.|.|.||||.||||:||.|..|.|||||:.:|..|:|.:.:....
plant  1353 VIDRN-PFGLDAEVSEGGENFSVGQRQLLSLARALLRRSKILFLDEATASVDVRTDSLIQRTIRE 1416

  Fly  2165 AFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVF 2212
            .|:..|::.|||||.||:|.|:::||..|:::|..:|:||...:.|.|
plant  1417 EFKSCTMLIIAHRLNTIIDCDKILVLSSGQVLEYDSPQELLSRDTSAF 1464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	94/382 (25%)
		TM helix 1	301..324	CDD:350035	9/22 (41%)
		TM helix 2	385..433	CDD:350035	15/49 (31%)
		TM helix 3	480..525	CDD:350035	14/44 (32%)
		TM helix 4	526..575	CDD:350035	13/48 (27%)
		TM helix 5	587..631	CDD:350035	10/43 (23%)
		TM helix 6	648..681	CDD:350035	12/32 (38%)
		ABCC_MRP_domain1	837..1043	CDD:213217	81/211 (38%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	85/341 (25%)
		TM helix 1	1475..1496	CDD:350046	7/20 (35%)
		TM helix 2	1520..1568	CDD:350046	10/47 (21%)
		TM helix 3	1575..1620	CDD:350046	15/47 (32%)
		TM helix 4	1621..1670	CDD:350046	11/48 (23%)
		TM helix 5	1682..1727	CDD:350046	14/45 (31%)
		TM helix 6	1777..1810	CDD:350046	10/32 (31%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	91/220 (41%)
ABCC11	NP_001319112.1	PLN03232	1..1495	CDD:215640	471/2193 (21%)