Protein Alignment Sur and ABCC15

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_191656.2
• Gene: ABCC15 / 825269
• AraportID: AT3G60970
• Length: 1053
• Species: Arabidopsis thaliana
• Alignment Length: 1754
• Identity: 365/1754 - (20%)
• Similarity: 601/1754 - (34%)
• Gaps: 742/1754 - (42%)

  Fly   490 MTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMT---PLQFFIGNAM 551
            |:.|.:.|.:|...::..|.:|.:|...||:|..:||:.|:...:..:::|.   ||.....|..
plant     1 MSVDVQRITDFIWYVNSIWMLPIQIFSAIYILQKHLGLGALAALVTTLMVMACNYPLTRLQRNYQ 65

  Fly   552 SKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNK-----DATFWT 611
            |.    |....|:|:|...:.|..:|::||.|||..||.|::..|:||...|.|     |.|.:.
plant    66 SD----IMNAKDDRMKATSEILKNMKILKLQAWDNQFLNKVKTLRKKEYDCLWKSLRLQDFTTFI 126

  Fly   612 LMAVLTHIATVLITFVT---LGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIII 673
            |....:.|:  ::||||   :||          .|.|..:.|:||.||.|..|:...|..:..::
plant   127 LWGAPSLIS--VVTFVTCMLMGV----------KLTAGAVLSALATFQMLQSPIFGLPDLLSALV 179

  Fly   674 AARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKR 738
            .::||..|:..:|:.||.||               ||
plant   180 QSKVSADRIASYLQQSETQK---------------DA---------------------------- 201

  Fly   739 LAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGS 803
                                .|..:.|          |
plant   202 --------------------VEYCSND----------H--------------------------- 209

  Fly   804 VMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPV---VQLHVPGIIVP 865
                 .|||                        |.|.:|.|:|:|:|..|.   ::|.     |.
plant   210 -----TEFS------------------------VEIENGAFSWEPESSRPTLDDIELK-----VK 240

  Fly   866 KGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTIS----YVSQQPWLLNDTIRENILF 926
            .|....:.|..||||:||.|::|.|:..|.|      |..:|    ||.|.||:|:.|||:||||
plant   241 SGMKVAICGAVGSGKSSLPSSILGEIQKLKG------TVRVSGKQAYVPQSPWILSGTIRDNILF 299

  Fly   927 GESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDD 991
            |..:..::|:..::||||..|.||...|||:.|||||||:||||:|||.||||:|.:|::.::||
plant   300 GSIYESEKYERTVKACALIKDFELFSNGDLTEIGERGINMSGGQKQRIQIARAVYQNADIYLLDD 364

  Fly   992 PLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELM 1056
            |.:::|...|..:|:.|:..:|:  ::|.:.||.|:..:..|:.::.:::|||...|.:.::
plant   365 PFSAVDAHTGRELFEDCLMGILK--DKTVLYVTHQVEFLPAADLILVMQNGRVMQAGKFEEL--- 424

  Fly  1057 QPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAI 1121
                                                                             
plant   425 ----------------------------------------------------------------- 424

  Fly  1122 DGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGD 1186
                      ::.|:                   ||.:                    :.:|
plant   425 ----------LKQNI-------------------GFEV--------------------LTQC--- 437

  Fly  1187 DVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDG 1251
                                :|.|.:|
plant   438 --------------------DSEHNIS-------------------------------------- 444

  Fly  1252 GDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHV 1316
                                                                             
plant   445 ----------------------------------------------------------------- 444

  Fly  1317 RGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKP 1381
                                                               |:..|.|
plant   445 ---------------------------------------------------TENKKKE------- 451

  Fly  1382 KKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLA 1446
                                                                         |:|.
plant   452 -------------------------------------------------------------AKLV 455

  Fly  1447 IDTERKYGKISDDIYLMYIRAAGLPIITIFFITA-LIWQCLRVYTDIWLQQWSNVHGRVASK--- 1507
            .|.|.:.|.|..::||.|:......::..|.|.| ..:|.|::.::.|:...:........|
plant   456 QDEETEKGVIGKEVYLTYLTTVKGGLLVPFIILAQSCFQMLQIASNYWMAWTAPPTAESIPKLGM 520

  Fly  1508 GHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHF 1572
            |.::|           .:.:.||.|.:|::...:....|   |.:.......::|.:|....:.:
plant   521 GRILL-----------VYALLAAGSSLCVLARTILVAIG---GLSTAETFFSRMLCSIFRAPMSY 571

  Fly  1573 FQVTPLGRIVNRFSNDMAVIDKKIAATGQRL--LQFTLLCLSAILINVTITPW-ILVLTLPICGA 1634
            |..||.|||:||.|.|.:|:|.::|.   :|  ..|:::.:...:..::...| :.|:.:|:..|
plant   572 FDSTPTGRILNRASTDQSVLDLEMAV---KLGWCAFSIIQIVGTIFVMSQVAWQVCVIFIPVAVA 633

  Fly  1635 YYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYA 1699
            ....|::|..:.|||.|:.....:|::.|.:|::.|.||||||:|:.||.......:::::..:.
plant   634 CVFYQRYYTPTERELSRMSGVERAPILHHFAESLAGATTIRAFDQRDRFISSNLVLIDSHSRPWF 698

  Fly  1700 LLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPS 1764
            .:.::..||...|:.|.. .||..::..|             .|.|....
plant   699 HVASAMEWLSFRLNLLSH-FVFAFSLVLL-------------VTLPEGVI--------------- 734

  Fly  1765 ELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVD 1829
                :||:.||.:.|.|.:.:....|:..:.:.|....|||||..:::       ..::|...:|
plant   735 ----NPSIAGLGVTYGLSLNVLQATVIWNICNAENKMISVERILQHSK-------IPSEAPLVID 788

  Fly  1830 ADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGH 1894
               |..|..|
plant   789 ---DQRPLDN------------------------------------------------------- 795

  Fly  1895 ENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLP 1959
                                                                             
plant   796 ----------------------------------------------------------------- 795

  Fly  1960 NEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSS 2024
                            ||..|.|.|.::.:||......|:.|:|...|.|::||:.||||||||:
plant   796 ----------------WPNVGSIVFRDLQVRYAEHFPAVLKNITCAFPGGKKIGVVGRTGSGKST 844

  Fly  2025 LGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLW 2089
            |..:||.:::.:.|.|.||:|||.:|...:||:||.|||||..||:.|||.||||...:.|.::|
plant   845 LIQALFRIVEPSHGTIVIDNVDITKIGLHDLRSRLGIIPQDNALFDGTIRLNLDPLAQYTDREIW 909

  Fly  2090 NCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSST 2154
            ..|:..||.:.:... ...||..:.:.|.|.|.|.|||:||.|.:|:.|..|||||||:.:||:|
plant   910 EALDKCQLGDVIRAK-DEKLDATVVENGENWSVGQRQLVCLGRVLLKKSNILVLDEATASVDSAT 973

  Fly  2155 ESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLEK 2218
            :..:.|..:..|:.||::|||||:.|:::.|.::||..|||.|..:|.:|.|.|.|.|..|:::
plant   974 DGVIQKIINQEFKDRTVVTIAHRIHTVIESDLVLVLSDGRIAEFDSPAKLLQREDSFFSKLIKE 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	59/202 (29%)
		TM helix 1	301..324	CDD:350035
		TM helix 2	385..433	CDD:350035
		TM helix 3	480..525	CDD:350035	10/34 (29%)
		TM helix 4	526..575	CDD:350035	12/51 (24%)
		TM helix 5	587..631	CDD:350035	16/51 (31%)
		TM helix 6	648..681	CDD:350035	10/32 (31%)
		ABCC_MRP_domain1	837..1043	CDD:213217	83/212 (39%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	77/342 (23%)
		TM helix 1	1475..1496	CDD:350046	6/21 (29%)
		TM helix 2	1520..1568	CDD:350046	8/47 (17%)
		TM helix 3	1575..1620	CDD:350046	14/46 (30%)
		TM helix 4	1621..1670	CDD:350046	13/49 (27%)
		TM helix 5	1682..1727	CDD:350046	8/44 (18%)
		TM helix 6	1777..1810	CDD:350046	9/32 (28%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	95/220 (43%)
ABCC15	NP_191656.2	MRP_assoc_pro	<1..1032	CDD:188098	363/1747 (21%)