Protein Alignment Sur and ABCC9

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_191575.2
• Gene: ABCC9 / 825186
• AraportID: AT3G60160
• Length: 1506
• Species: Arabidopsis thaliana
• Alignment Length: 2233
• Identity: 468/2233 - (20%)
• Similarity: 791/2233 - (35%)
• Gaps: 872/2233 - (39%)

  Fly    73 AISLLLLALNSFDLARIFLPHQNVRNLNRLFQSSPRDL-NYLVVIGSGELWN-------ALFSTL 129
            |..|:.|||..|.:.|           ||.......|| ...:.:.....:|       ::..|.
plant    43 AFFLIHLALKWFGVVR-----------NRGSNDVEEDLKKQSITVKQSFSYNISLLCSVSILGTH 96

  Fly   130 LTLMLMLYH-RMVERKKATVFLYASTAVEALTFALLS---------------------------- 165
            ..::|:|:. .:|.|..::|.::::...::.::..:|
plant    97 CFILLLLFRDSVVSRCDSSVSVFSAEVSQSFSWLFVSVVVVKIRERRLVKFPWMLRSWWLCSFIL 161

  Fly   166 ---------NELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYH------DDYLDD 215
                     ....|.:.::|:.:| |.|:|...:..||:....|..:.:...:      .|..:.
plant   162 SFSFDAHFITAKHEPLEFQDYADL-TGLLASLFLLAVSIRGKTGFHLLESSGNTEPLLLGDQTEQ 225

  Fly   216 YGKIGYKHSM----ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSAR--SH-YDHFLYI 273
            ..|..|..|.    ||.:.:..|.|:.||..||||.|||.:|:..:.::||||  || :|..|
plant   226 NKKDSYSSSSPYGNATLFQRITFSWINPLFSLGYKRPLEKDDVPDIDVKDSARFCSHAFDQKL-- 288

  Fly   274 YTEKKKKSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPP 338
            .|.|:|:...:...:...::..|:..|:..:..:.....|.|||..|...||::.:..:|:
plant   289 KTTKEKEGPGNAFFYNSVLRYVWRKAAINAVFAVVNASTAYIGPYLINDFVEFLSEKQSQS---- 349

  Fly   339 AKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGAL 403
                                                        |.:|:.:|...|.|.|.:...
plant   350 --------------------------------------------LNHGYLLALGFLTAKIVETVT 370

  Fly   404 SQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATP 468
            .:.........|:|::.:|...||:|.|:|:
plant   371 QRQWIFGARQLGLRLRAALISHIYQKGLVLS---------------------------------- 401

  Fly   469 EHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGS 533
                  |:...||..|.|.|:|:.|.:.|.:|...::..|.:|.:|...||:|..:||:.|:...
plant   402 ------SQSRQSHTSGEIINYMSVDVQRITDFIWYVNNIWMLPIQIFSAIYILQKHLGLGALAAL 460

  Fly   534 IACIVIMT---PLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEA 595
            :..:::|.   ||.....|..|.    |....|:|:|...:.|..:|::||.|||..||.|::..
plant   461 VTTLMVMACNYPLTRLQRNYQSD----IMNAKDDRMKATSEILKNMKILKLQAWDNQFLNKVKTL 521

  Fly   596 RRKELKYLNKD------ATF--WTLMAVLTHIATVLITFVT---LGVYVWLHRDQEFDLNASRLF 649
            |:||...|.|.      .||  |...::::     ::||||   :||          .|.|..:.
plant   522 RKKEYDCLWKSLRLQAFTTFILWGAPSLIS-----VVTFVTCMLMGV----------KLTAGAVL 571

  Fly   650 SSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDM 714
            |:||.||.|..|:...|..:..::.::||..|:..:|:.||.||               ||
plant   572 SALATFQMLQSPIFGLPDLLSALVQSKVSADRIASYLQQSETQK---------------DA---- 617

  Fly   715 YETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKL 779
                                                        .|..::|          |.:|
plant   618 --------------------------------------------VEYCSKD----------HTEL 628

  Fly   780 VQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLF 844
                                                                    :|.|.:|.|
plant   629 --------------------------------------------------------SVEIENGAF 637

  Fly   845 TWQPQSQMPV---VQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTI 906
            :|:|:|..|.   ::|.     |..|....|.|..||||:||||::|.|:..|.|      |..:
plant   638 SWEPESSRPTLDDIELK-----VKSGMKVAVCGAVGSGKSSLLSSILGEIQKLKG------TVRV 691

  Fly   907 S----YVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINIS 967
            |    ||.|.||:|:.|||:|||||..:..::|:..::||||..|.||...|||:.|||||||:|
plant   692 SGKQAYVPQSPWILSGTIRDNILFGSMYESEKYERTVKACALIKDFELFSNGDLTEIGERGINMS 756

  Fly   968 GGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKE 1032
            |||:|||.||||:|.:|::.::|||.:::|...|..:|:.|:..:|:  ::|.:.||.|:..:..
plant   757 GGQKQRIQIARAVYQNADIYLLDDPFSAVDAHTGRELFEDCLMGILK--DKTVLYVTHQVEFLPA 819

  Fly  1033 AEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNV 1097
            |:.::.:::|||...|.:.:                                        |||.
plant   820 ADLILVMQNGRVMQAGKFEE----------------------------------------LLKQ- 843

  Fly  1098 SKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRK 1162
                     ::..:..|..|.:|:|
plant   844 ---------NIGFEVLVGAHNEALD---------------------------------------- 859

  Fly  1163 RSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSI 1227
                                                                             
plant   860 ----------------------------------------------------------------- 859

  Fly  1228 SGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVAN 1292
                                                                             
plant   860 ----------------------------------------------------------------- 859

  Fly  1293 PDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPP 1357
                                                                  |||||.:.|.
plant   860 ------------------------------------------------------SILSIEKSSR- 869

  Fly  1358 VVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQH 1422
              :|      .:|:|::|.|        ..:|.:|  :||                      .:|
plant   870 --NF------KEGSKDDTAS--------IAESLQT--HCD----------------------SEH 894

  Fly  1423 NERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITA-LIWQCL 1486
            |       ::.|:.::.   |:|..|.|.:.|.|..::||.|:......::..|.|.| ..:|.|
plant   895 N-------ISTENKKKE---AKLVQDEETEKGVIGKEVYLAYLTTVKGGLLVPFIILAQSCFQML 949

  Fly  1487 RVYTDIWLQQWSNVHGRVASK---GHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQY 1548
            ::.::.|:...:........|   |.::|           .:.:.||.|.:|::...:....|
plant   950 QIASNYWMAWTAPPTAESIPKLGMGRILL-----------VYALLAAGSSLCVLARTILVAIG-- 1001

  Fly  1549 AGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRL--LQFTLLCL 1611
             |.:.......::|.:|....:.||..||.|||:||.|.|.:|:|.::|.   :|  ..|:::.:
plant  1002 -GLSTAETFFSRMLCSIFRAPMSFFDSTPTGRILNRASTDQSVLDLEMAV---KLGWCAFSIIQI 1062

  Fly  1612 SAILINVTITPW-ILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIR 1675
            ...:..::...| :.|:.:|:..|....|::|..:||||.|:.....:|::.|.:|::.|.||||
plant  1063 VGTIFVMSQVAWQVCVIFIPVAVACVFYQRYYTPTARELSRMSGVERAPILHHFAESLAGATTIR 1127

  Fly  1676 AFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYE 1740
            ||:|:.||.......:::::..:..:.::..||...|:.|.. .||..::..|
plant  1128 AFDQRDRFISSNLVLIDSHSRPWFHVASAMEWLSFRLNLLSH-FVFAFSLVLL------------ 1179

  Fly  1741 ATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVE 1805
             .|.|....                   :||:.||.:.|.|.:.:....|:..:.:.|....|||
plant  1180 -VTLPEGVI-------------------NPSIAGLGVTYGLSLNVLQATVIWNICNAENKMISVE 1224

  Fly  1806 RIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVD 1870
            ||..|::       ..::|...:|.   |.|..|
plant  1225 RILQYSK-------IPSEAPLVIDG---HRPLDN------------------------------- 1248

  Fly  1871 EDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATT 1935
                                                                             
plant  1249 ----------------------------------------------------------------- 1248

  Fly  1936 KTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVIS 2000
                                                    ||..|.|.|.::.:||......|:.
plant  1249 ----------------------------------------WPNVGSIVFRDLQVRYAEHFPAVLK 1273

  Fly  2001 NLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQD 2065
            |:|.:.|.|::||:.||||||||:|..:||.:::.::|.|.||:|||.:|...:||:||.|||||
plant  1274 NITCEFPGGKKIGVVGRTGSGKSTLIQALFRIVEPSQGTIVIDNVDITKIGLHDLRSRLGIIPQD 1338

  Fly  2066 VHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCL 2130
            ..||:.|||.||||...:.|.::|..::..||.:.:... ...||..:.:.|.|.|.|.|||:||
plant  1339 PALFDGTIRLNLDPLAQYTDHEIWEAIDKCQLGDVIRAK-DERLDATVVENGENWSVGQRQLVCL 1402

  Fly  2131 ARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRI 2195
            .|.:|:.|..|||||||:.:||:|:..:.|..:..|:.||::|||||:.|:::.|.::||..|||
plant  1403 GRVLLKKSNILVLDEATASVDSATDGVIQKIINQEFKDRTVVTIAHRIHTVIESDLVLVLSDGRI 1467

  Fly  2196 VEDGNPRELQQLEGSVFRGLLEK 2218
            .|..:|.:|.|.|.|.|..|:::
plant  1468 AEFDSPAKLLQREDSFFSKLIKE 1490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	86/394 (22%)
		TM helix 1	301..324	CDD:350035	5/22 (23%)
		TM helix 2	385..433	CDD:350035	12/47 (26%)
		TM helix 3	480..525	CDD:350035	15/44 (34%)
		TM helix 4	526..575	CDD:350035	12/51 (24%)
		TM helix 5	587..631	CDD:350035	15/54 (28%)
		TM helix 6	648..681	CDD:350035	10/32 (31%)
		ABCC_MRP_domain1	837..1043	CDD:213217	85/212 (40%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	79/342 (23%)
		TM helix 1	1475..1496	CDD:350046	6/21 (29%)
		TM helix 2	1520..1568	CDD:350046	8/47 (17%)
		TM helix 3	1575..1620	CDD:350046	14/46 (30%)
		TM helix 4	1621..1670	CDD:350046	14/49 (29%)
		TM helix 5	1682..1727	CDD:350046	8/44 (18%)
		TM helix 6	1777..1810	CDD:350046	9/32 (28%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	94/220 (43%)
ABCC9	NP_191575.2	MRP_assoc_pro	236..1485	CDD:188098	434/2021 (21%)