Protein Alignment Sur and ABCC3

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_187915.1
• Gene: ABCC3 / 820496
• AraportID: AT3G13080
• Length: 1514
• Species: Arabidopsis thaliana
• Alignment Length: 2199
• Identity: 466/2199 - (21%)
• Similarity: 743/2199 - (33%)
• Gaps: 869/2199 - (39%)

  Fly   110 LNYLVVIGSGELW--------NALFSTLLTLMLML--------YHRM--VERKKATVFLYASTAV 156
            ||.:::..||..|        ..|.|:|..|:.|:        .||.  .|.|||. ||.....|
plant    93 LNLVLMSLSGFYWYESGWLDNEQLVSSLGFLLGMVSWGVLSICLHRCRDCEHKKAP-FLLRLWLV 156

  Fly   157 EALTFALLSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDDYLDDYG---- 217
            ..|..:..| .:.:.|.||....:...|:....:..::...|..:.|.|:    |..:..|
plant   157 FYLVVSCYS-LVVDFVMYERRETVPVHLLVFDIVAFIAAVFLGYVAVLKK----DRSNSNGVLEE 216

  Fly   218 --------KIGYKHSM----------ATFYSKS------CFWWLTPLLWLGYKEPLELEDLGQMK 258
                    ::|...|:          ||.||::      .|.|::||:.:|.|:.|:|||:.|:.
plant   217 PLLNGGDSRVGGDDSVELNKTNGSGEATPYSRAGILSLLTFSWMSPLIDIGNKKTLDLEDVPQLH 281

  Fly   259 LEDSARSHYDHFLYIYTEKKKKSNSSPSLW----YCYIKNSWQMFALGGILKLAGDLFALI---- 315
            ..||.......|..:.........|..:.:    ..|....|::        |....||.|
plant   282 DTDSVVGLAPKFRSMLESPDGGERSGVTTFKLIKALYFTAQWEI--------LVTAFFAFIYTVA 338

  Fly   316 ---GPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSS 377
               ||..|...|:|:.          .:...|....||:
plant   339 SYVGPALIDTFVQYLN----------GRRQYNHEGYVLV-------------------------- 367

  Fly   378 TWSDLLANGWCIAWIVLLAAITQGALSQASTHI-LNMTGIRIKTSLQGLIYRKSLLLNADGGCDS 441
                          |...||.....|||..... |...|||::::|..:||.|.|.|:    |.|
plant   368 --------------ITFFAAKIVECLSQRHWFFRLQKVGIRMRSALVAMIYEKGLTLS----CQS 414

  Fly   442 SDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHY 506
            .      |..:|                              |.|.|.||.|...|..|...:|.
plant   415 K------QGRTS------------------------------GEIINFMTVDAERIGNFSWYMHD 443

  Fly   507 AWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHD 571
            .|.:..::.:.:::||.|||::::...:|.|::|. :.|..|....:..|.:....|.|:|...:
plant   444 PWMVLLQVGLALWILYRNLGLASIAALVATIIVML-INFPFGRMQERFQEKLMEAKDSRMKSTSE 507

  Fly   572 TLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNK--------DATFW---TLMAVLTHIATVLIT 625
            .|..::::||..|:..||.||.:.|:.|..:|.|        ...||   ||::|.|..|.:|
plant   508 ILRNMRILKLQGWEMKFLSKIFDLRKSEEGWLKKYVYNSAVISFVFWGAPTLVSVSTFGACIL-- 570

  Fly   626 FVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSE 690
               ||:          .|.:.::.|:||.|:.|..|:...|.|:.:|:..:||..||..:|
plant   571 ---LGI----------PLESGKILSALATFRILQEPIYNLPDTISMIVQTKVSLDRLASYL---- 618

  Fly   691 IQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPL 755
                                                                             
plant   619 ----------------------------------------------------------------- 618

  Fly   756 LQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTD 820
                  ..:::.|..|:.|                       ||  ||
plant   619 ------CLDNLQPDIVERL-----------------------PK--GS----------------- 635

  Fly   821 SWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLS 885
                        .|:||.:.:...:|...|..|.:: .:...:.| |....|.|..||||:||||
plant   636 ------------SDVAVEVINSTLSWDVSSSNPTLK-DINFKVFP-GMKVAVCGTVGSGKSSLLS 686

  Fly   886 ALLMEMPLLAGNMFWHKTC-TISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIE 949
            :||.|:|.::|::   |.| |.:||:|.||:.:..|.:|||||:....:|||.|||||:|..|:|
plant   687 SLLGEVPKVSGSL---KVCGTKAYVAQSPWIQSGKIEDNILFGKPMERERYDKVLEACSLSKDLE 748

  Fly   950 LMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQ 1014
            ::..||.::|||||||:||||:|||.||||:|..|::.:.|||.:::|...|.|:|:..:..:|
plant   749 ILSFGDQTVIGERGINLSGGQKQRIQIARALYQDADIYLFDDPFSAVDAHTGSHLFKEVLLGLL- 812

  Fly  1015 KSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPS 1079
             .:::.|.||.|:..:..|:.::.:||||:...|.|.||
plant   813 -CSKSVIYVTHQVEFLPAADLILVMKDGRISQAGKYNDI-------------------------- 850

  Fly  1080 QNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVS 1144
                 ..:|..:..|                   :..|.:|:             .||:..|..|
plant   851 -----LNSGTDFMEL-------------------IGAHQEAL-------------AVVDSVDANS 878

  Fly  1145 VSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSS 1209
            ||                ..|..|..:::....:.:||
plant   879 VS----------------EKSALGQENVIVKDAIAVDE--------------------------- 900

  Fly  1210 HRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTH 1274
                       ..||..:..|                               :::|.:|.:.:
plant   901 -----------KLESQDLKND-------------------------------KLESVEPQRQI-- 921

  Fly  1275 HQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHH 1339
                                                                             
plant   922 ----------------------------------------------------------------- 921

  Fly  1340 HPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSAS 1404
                       |.||
plant   922 -----------IQEE-------------------------------------------------- 925

  Fly  1405 DKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAA- 1468
                                                         ||:.|.::.|:|..||..|
plant   926 ---------------------------------------------EREKGSVALDVYWKYITLAY 945

  Fly  1469 GLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHE---------VTYY 1524
            |..::....:..:::|.|::.::.|: .|:.              |..:|.:         :.|.
plant   946 GGALVPFILLGQVLFQLLQIGSNYWM-AWAT--------------PVSEDVQAPVKLSTLMIVYV 995

  Fly  1525 FRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDM 1589
            ...:.:..|:.:...|:.|     ||......|..|:...|....:.||..||.|||::|.|.|.
plant   996 ALAFGSSLCILLRATLLVT-----AGYKTATELFHKMHHCIFRSPMSFFDSTPSGRIMSRASTDQ 1055

  Fly  1590 AVIDKKIAATGQRLLQF-----TLLCLSAILINVTITPWILVLT-LPICGAYYLIQKFYRCSARE 1648
            :.:|.::.      .||     |::.|..|:..::...|::.|. :|:..|....|::|..:|||
plant  1056 SAVDLELP------YQFGSVAITVIQLIGIIGVMSQVSWLVFLVFIPVVAASIWYQRYYIAAARE 1114

  Fly  1649 LQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLD 1713
            |.|:.....:|:|.|.||||.|.||||:|:|:.||.....:..:..:........:..||...||
plant  1115 LSRLVGVCKAPLIQHFSETISGATTIRSFSQEFRFRSDNMRLSDGYSRPKFYTAGAMEWLCFRLD 1179

  Fly  1714 YLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAIN 1778
            .|.. :.||.::..|.:                       ..|..:         .|||.|||:.
plant  1180 MLSS-LTFVFSLVFLVS-----------------------IPTGVI---------DPSLAGLAVT 1211

  Fly  1779 YTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVS 1843
            |.|.:.....|::..|.::|....|||||..||.                      .||
plant  1212 YGLSLNTLQAWLIWTLCNLENKIISVERILQYAS----------------------VPS------ 1248

  Fly  1844 AEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAG 1908
                                                                             
plant  1249 ----------------------------------------------------------------- 1248

  Fly  1909 NVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVP 1973
                        .||.                               |:..|.|.:
plant  1249 ------------EPPL-------------------------------VIESNRPEQ--------- 1261

  Fly  1974 ISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRG 2038
             |||.||::...::.:||......|:..:|.....|.|.||.||||||||:|..:||.:::.:.|
plant  1262 -SWPSRGEVEIRDLQVRYAPHMPLVLRGITCTFKGGLRTGIVGRTGSGKSTLIQTLFRIVEPSAG 1325

  Fly  2039 HIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNG 2103
            .|.||.|:|..|...:||.||||||||..:|..|:|.||||...:.|.|:|..|:..||.:.|.
plant  1326 EIRIDGVNILTIGLHDLRLRLSIIPQDPTMFEGTMRSNLDPLEEYTDDQIWEALDKCQLGDEVR- 1389

  Fly  2104 HLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRG 2168
            .....||:.:.:.|.|.|.|.|||:||.|.:|:.|..|||||||:.:|::|::.:.|.....|..
plant  1390 KKEQKLDSSVSENGDNWSMGQRQLVCLGRVLLKRSKILVLDEATASVDTATDNLIQKTLREHFSD 1454

  Fly  2169 RTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLEKGASK 2222
            .|:||||||:::::|.|.:::|..|.|.|...|..|.:.:.|.|..|:.:..|:
plant  1455 CTVITIAHRISSVIDSDMVLLLSNGIIEEYDTPVRLLEDKSSSFSKLVAEYTSR 1508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	90/399 (23%)
		TM helix 1	301..324	CDD:350035	7/29 (24%)
		TM helix 2	385..433	CDD:350035	15/48 (31%)
		TM helix 3	480..525	CDD:350035	12/44 (27%)
		TM helix 4	526..575	CDD:350035	11/48 (23%)
		TM helix 5	587..631	CDD:350035	17/54 (31%)
		TM helix 6	648..681	CDD:350035	11/32 (34%)
		ABCC_MRP_domain1	837..1043	CDD:213217	83/206 (40%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	83/350 (24%)
		TM helix 1	1475..1496	CDD:350046	3/20 (15%)
		TM helix 2	1520..1568	CDD:350046	9/56 (16%)
		TM helix 3	1575..1620	CDD:350046	14/49 (29%)
		TM helix 4	1621..1670	CDD:350046	18/49 (37%)
		TM helix 5	1682..1727	CDD:350046	9/44 (20%)
		TM helix 6	1777..1810	CDD:350046	10/32 (31%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	89/220 (40%)
ABCC3	NP_187915.1	MRP_assoc_pro	115..1499	CDD:188098	458/2166 (21%)