DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sur and Abcc6

DIOPT Version :9

Sequence 1:NP_001334732.1 Gene:Sur / 34350 FlyBaseID:FBgn0028675 Length:2223 Species:Drosophila melanogaster
Sequence 2:NP_112275.1 Gene:Abcc6 / 81642 RGDID:620268 Length:1502 Species:Rattus norvegicus


Alignment Length:2238 Identity:480/2238 - (21%)
Similarity:761/2238 - (34%) Gaps:846/2238 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 IFLLLFG---LMFVCSRYKKCHKTLLTFHNGRAAISLLLLALNSFDLARIFLPHQNVRNLNRLFQ 104
            ::|.:.|   |::: .|:..|:..:......:..:...|:.|.:|:.|   :|      |.|:.:
  Rat    48 MYLWVLGPIYLLYI-HRHGCCYLRMSRLFKIKMVLGFALILLYTFNAA---VP------LWRIHR 102

  Fly   105 SSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKAT-----VFLY---------ASTA 155
            ..|:....|:   ...:|    .|.::....|.|  :||||..     :|.|         ..|.
  Rat   103 GMPQAPELLI---HPTVW----LTTMSFATFLIH--MERKKGVRASGLLFGYWLLCCLVPAIDTV 158

  Fly   156 VEALTFALLSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDDYLDDYGKIG 220
            .:|...:.....|..|..|       .||..:.|..::| .::|....:.|       |......
  Rat   159 QQASAGSFRQEPLHHLATY-------LCLSLVVAELVLS-CLVDQPPFFSE-------DSKPLNP 208

  Fly   221 YKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSAR------------------SHY 267
            ...:.|:|.||:.|||.:.|||.||::.|..:||..::.|:|:.                  .|.
  Rat   209 CPEAEASFPSKAMFWWASGLLWKGYRKLLGPKDLWSLERENSSEELVSQLEREWRRNFSELPGHK 273

  Fly   268 DHF--------LYIYTEKKKKSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIV 324
            .|.        .::..|:.::.....::|..:...    |.||.:..:..|.|....|..:...:
  Rat   274 GHSGMGTPETEAFLQPERSQRGPLLRAIWRVFRST----FLLGTLSLVISDAFRFAVPKLLSLFL 334

  Fly   325 EYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCI 389
            |::..|                                            .||.|:     ||.:
  Rat   335 EFMGDL--------------------------------------------ESSAWT-----GWLL 350

  Fly   390 AWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSST 454
            |.::.|:|..|....|...:.:.:..:|::|::.||:|||.|:|          |:|..:|::: 
  Rat   351 AVLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLVYRKVLVL----------SSGSRKSSAA- 404

  Fly   455 SDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIY 519
                                         |.:.|.::.|.:.::|..|.::..|.:...|.|...
  Rat   405 -----------------------------GDVVNLVSVDVQRLVESILHLNGLWLLFLWIIVCFV 440

  Fly   520 LLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAW 584
            .|:..||.|| :.::|..:.:.||.|||....|.:.|........|.:.....|..::.||.:.|
  Rat   441 YLWQLLGPSA-LTAVAVFLSLLPLNFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHGW 504

  Fly   585 DEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLF 649
            :..||:::...|.:||..|...|..:::..|...::|.|:..|...|:..:..|...|  |.:.|
  Rat   505 ECAFLERLLHIRGQELGALKTSAFLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMD--AEKAF 567

  Fly   650 SSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDM 714
            .:|.:...|.......|.:|..::.||||..||..||                            
  Rat   568 VTLTVLSILNKAQAFLPFSVHCLVQARVSFDRLAAFL---------------------------- 604

  Fly   715 YETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKL 779
                                                    .|:..:.:...:|||          
  Rat   605 ----------------------------------------CLEEVDPNGMVLSPS---------- 619

  Fly   780 VQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLF 844
                                 |.|..:|                             :||::|.|
  Rat   620 ---------------------RCSSKDR-----------------------------ISIHNGTF 634

  Fly   845 TWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYV 909
            .|..:|. |.  ||...:.||:|.|..|||..|:||:|||||||.|:..:.|::....  :::||
  Rat   635 AWSQESP-PC--LHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEG--SVAYV 694

  Fly   910 SQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRI 974
            .|:.|:.|.::.||:.|.:.........|||||||..|:...|.|..:.:||:|:|:||||:||:
  Rat   695 PQEAWVQNTSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQGMNLSGGQKQRL 759

  Fly   975 AIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCI--REMLQKSNRTFILVTQQLHRIKEAEYLI 1037
            ::|||:|..|.|.:||||||:||..|.:.:|:..|  ..:||.:.|  ||||..||.:.:|:.::
  Rat   760 SLARAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQGTTR--ILVTHTLHVLPQADQIL 822

  Fly  1038 AIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGL 1102
            .:.:|.:...|||.|:                                       |.:|.:.:||
  Rat   823 VLANGTIAEMGSYQDL---------------------------------------LHRNGALVGL 848

  Fly  1103 QRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIY 1167
                              :||:                     ..|.|...              
  Rat   849 ------------------LDGA---------------------RQPAGEGE-------------- 860

  Fly  1168 GSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVL 1232
            |..|                                                |.:.|..:.|   
  Rat   861 GEAH------------------------------------------------AAATSDDLGG--- 874

  Fly  1233 SRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKK 1297
                            ..||...|..||                                     
  Rat   875 ----------------FSGGGTPTRRPE------------------------------------- 886

  Fly  1298 SEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFP 1362
                                                :|:                         |
  Rat   887 ------------------------------------RPR-------------------------P 890

  Fly  1363 ASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHV 1427
            :......|:.:|.|.|.               :.||                             
  Rat   891 SDAAPVKGSTSEAQMEP---------------SLDD----------------------------- 911

  Fly  1428 LAEVAG-ESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTD 1491
             .||.| .:|.:|:           :||::....||.|:||.|.|:.|......|..|.......
  Rat   912 -VEVTGLTAGEDSV-----------QYGRVKSATYLSYLRAVGTPLCTYTLFLFLCQQVASFCQG 964

  Fly  1492 IWLQQWSN---VHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNA 1553
            .||..|::   |.|:   :.|..|..|           ::..:.|:..|....|..|....|..|
  Rat   965 YWLSLWADDPVVDGK---QMHSALRGS-----------IFGLLGCLQAIGLFASMAAVFLGGARA 1015

  Fly  1554 RRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINV 1618
            ...|...||..:....:.||:.||:|.::||||.:..::|..|....:.||.:....|...|...
  Rat  1016 SCLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDIVDVDIPDKMRTLLTYAFGLLEVGLAVS 1080

  Fly  1619 TITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRF 1683
            ..||..:|..||:...|...|..|..:..:|:|:|:|:.|.|.|||:||.||...:|||..|..|
  Rat  1081 MATPLAIVAILPLMLLYAGFQSLYVATCCQLRRLESASYSSVCSHLAETFQGSQVVRAFQAQGPF 1145

  Fly  1684 T-----------EILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRR 1737
            |           .|.|.||.|:           |||..:|:.||..:||||...|:.        
  Rat  1146 TAQHDALMDENQRISFPRLVAD-----------RWLAANLELLGNGLVFVAATCAVL-------- 1191

  Fly  1738 HYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAG 1802
                                      |:...|..|.|.:::..|.|...|.|||:...|:|....
  Rat  1192 --------------------------SKAHLSAGLAGFSVSAALQVTQTLQWVVRSWTDLENSMV 1230

  Fly  1803 SVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAG 1867
            :|||:..|.                                                        
  Rat  1231 AVERVQDYV-------------------------------------------------------- 1239

  Fly  1868 DVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQ 1932
                                                                 |.|         
  Rat  1240 -----------------------------------------------------HTP--------- 1242

  Fly  1933 ATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQN 1997
                      |:.|.:         ||:..|:.|         ||..|.|.|.:..||:..:...
  Rat  1243 ----------KEAPWR---------LPSSAAQPL---------WPCGGQIEFRDFGLRHRPELPM 1279

  Fly  1998 VISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSII 2062
            .:..::|||.||:::||.||||:|||||...|..:.:.|.|.|:||.|.|..:....||:|::||
  Rat  1280 AVQGVSLKIHAGEKVGIVGRTGAGKSSLTWGLLRLQEATEGGIWIDGVPITDMGLHTLRSRITII 1344

  Fly  2063 PQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDG-GLNLSAGHRQ 2126
            |||..||..::|.|||......|..:|..||..|||.||.. || |.....|.| |.:||.|.:|
  Rat  1345 PQDPVLFPGSLRMNLDLLQENTDEGIWAALETVQLKAFVTS-LP-GQLQYECSGQGDDLSVGQKQ 1407

  Fly  2127 LLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLD 2191
            |||||||:||.:..|:|||||:.:|..||..:..|.:..|...|::.|||||.::::..|::|:|
  Rat  1408 LLCLARALLRKTQILILDEATASVDPGTEIQMQAALERWFAQCTVLLIAHRLRSVMNCARVLVMD 1472

  Fly  2192 QGRIVEDGNPRELQQLEGSVFRGLLEKG 2219
            :|::.|.|:|.:|...:|..:|...|.|
  Rat  1473 EGQVAESGSPAQLLAQKGLFYRLAQESG 1500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SurNP_001334732.1 None
Abcc6NP_112275.1 MRP_assoc_pro 36..1501 CDD:188098 480/2238 (21%)
ABC_membrane 313..577 CDD:294371 70/355 (20%)
ABCC_MRP_domain1 627..828 CDD:213217 83/207 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 854..909 18/248 (7%)
ABC_membrane 950..1215 CDD:294371 83/323 (26%)
ABCC_MRP_domain2 1262..1482 CDD:213211 94/221 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.110

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