DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and Abcc3

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001350116.1	Gene:	Abcc3 / 76408	MGIID:	1923658	Length:	1523	Species:	Mus musculus

Alignment Length:	2197	Identity:	506/2197 - (23%)
Similarity:	809/2197 - (36%)	Gaps:	816/2197 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LFQSSPRDLNYLVVIGSGELWNALFSTLLTLMLML---------YHRMVERKKATVFLYASTAVE 157
            ||......|.|:|:     .|.:...|.|.::|..         :|.::.........:.:..|.
Mouse    53 LFYLRHHQLGYIVL-----SWLSRLKTALGVLLWCVSWVDLFYSFHGLIHGSSPAPVFFVTPLVV 112

  Fly   158 ALTFALLSNELFELVRYEDFLELQT--CLVAMSAMCMVSL----------AMLDG---------- 200
            .:|..|.:    .|::||....:|:  .|:....:|::..          |:.:|
Mouse   113 GITMLLAT----LLIQYERLRGVQSSGVLIIFWLLCVICAIIPFRSKILSALAEGKILDPFRFTT 173

  Fly   201 -------------LTVYKE---CYHDDYLDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPL 249
                         |:.:||   .:..:.||..   ....:.|.|:|:..|||.|.|..|||:.||
Mouse   174 FYIYFALVFCALILSCFKEKPPLFSPENLDTN---PCPEASAGFFSRLSFWWFTRLAILGYRRPL 235

  Fly   250 ELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSS-------------------------PSLWY 289
            |..||..:..||.:.......|..:.:::.:::.|                         ||...
Mouse   236 EDRDLWSLSEEDCSHKVVQRLLEAWQKQQNQASRSQTATAEPKIPGEDAVLLKPRPKSKQPSFLR 300

  Fly   290 CYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTS 354
            ..::.......:.....|..:|...:.|..:..::.:|       |:|.|
Mouse   301 ALVRTFTSSLLMSACFNLIQNLLGFVNPQLLSILIRFI-------SDPTA--------------- 343

  Fly   355 RILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIK 419
                                  .||.     |:.:|.::.|::..|..:.....|.:.:..:|::
Mouse   344 ----------------------PTWW-----GFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLR 381

  Fly   420 TSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIG 484
            |::.|:||||:|::                 |:|...|.                       .:|
Mouse   382 TAIIGVIYRKALVI-----------------TNSVKRES-----------------------TVG 406

  Fly   485 SITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGN 549
            .:.|.|:.|.:..|:....|:..|:.|.::.:.||.|:..||.||:.| :|.||::.||...:..
Mouse   407 EMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAG-VAVIVLLIPLNGAVSM 470

  Fly   550 AMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMA 614
            .|.........:.|.|:|.:.:.|.||||:||.||:..||::::..|:.||:.|.|.|   .|.|
Mouse   471 KMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGA---YLQA 532

  Fly   615 VLTHI---ATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAAR 676
            :.|.|   ...|:|.:||||||::  |:...|:|.:.|.||:||..|.:||.:.|..:..:..|.
Mouse   533 ISTFIWICTPFLVTLITLGVYVYV--DESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQAS 595

  Fly   677 VSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQ 741
            ||.:|::.||..:|:.
Mouse   596 VSLKRIQDFLNQNELD------------------------------------------------- 611

  Fly   742 KSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVME 806
                |:.....|            |||.
Mouse   612 ----PQCVERKT------------ISPG------------------------------------- 623

  Fly   807 RPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTI 871
                                        .|::|::|.||| .|...|.  ||...|.:|||.|..
Mouse   624 ----------------------------YAITIHNGTFTW-AQDLPPT--LHSLNIQIPKGALVA 657

  Fly   872 VVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYD 936
            |||..|.||:||:||||.||..|.|.:  ....:::||.||.|:.|.|::||:|||:...||||.
Mouse   658 VVGPVGCGKSSLVSALLGEMEKLEGVV--SVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQ 720

  Fly   937 FVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVG 1001
            ..||.|||..|::::|.||.:.|||:|||:|||||||:::|||:||.||:.::||||:::|:.|.
Mouse   721 QALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVA 785

  Fly  1002 EHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNA 1066
            :|||...|......:.:|.:|||..:..:.:.:::|.:..|:|...|.|:.:
Mouse   786 KHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAGGQVSEMGHYSAL------------- 837

  Fly  1067 IIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVAN 1131
                                               ||.                 ||    |.||
Mouse   838 -----------------------------------LQH-----------------DG----SFAN 846

  Fly  1132 MQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRH 1196
            ...|...::||......:.||:                                ::|:
Mouse   847 FLRNYAPDEDQEDHEAALQNAN--------------------------------EEVL------- 872

  Fly  1197 TLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEP 1261
                                               |....|:|
Mouse   873 -----------------------------------LLEDTLST---------------------- 880

  Fly  1262 RVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRR 1326
                         |..|:.|       |.|..:|:|                        ||:|.
Mouse   881 -------------HTDLTDN-------EPAIYEVRK------------------------QFMRE 901

  Fly  1327 MSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKE 1391
            ||                     |:|.|                  .|.|:...|||..|...||
Mouse   902 MS---------------------SLSSE------------------GEVQNRTMPKKHTNSLEKE 927

  Fly  1392 TTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKI 1456
            ..:        ...||..|.:            :..:||.                      |.:
Mouse   928 ALV--------TKTKETGALI------------KEEIAET----------------------GNV 950

  Fly  1457 SDDIYLMYIRAAGLPIITIFFITALI--WQCLRVYTDIWLQQWSN---VHGRVASKGHVVLHPSE 1516
            ...:|..|.::.||  .|...|..|.  .....:..::||..|||   .||
Mouse   951 KLSVYWDYAKSMGL--CTTLSICLLYGGQSAAAIGANVWLSAWSNDAEEHG-------------- 999

  Fly  1517 QDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRI 1581
            |.::.:....:|||:..:..::.::|..........|.|.||:.||...:.....||..||.|||
Mouse  1000 QQNKTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRI 1064

  Fly  1582 VNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSA 1646
            :||||.|:.|||:.:|.|...||......:|.|::.|..||..:|:.||:...|..:|:||..::
Mouse  1065 LNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATS 1129

  Fly  1647 RELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVS 1711
            |:|:|:|:.:.||:.||.|||:.|.:.|||:.:...|..:...:::.|..:......|:|||||.
Mouse  1130 RQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVH 1194

  Fly  1712 LDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLA 1776
            ::::|.|:|..|.:.|:...:                                  ..:|.||||:
Mouse  1195 VEFVGNCVVLFAALFAVIGRN----------------------------------SLNPGLVGLS 1225

  Fly  1777 INYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNED 1841
            ::|.|.|.:.|||::::::|:|....:|||:..|::
Mouse  1226 VSYALQVTMALNWMIRMISDLESNIIAVERVKEYSK----------------------------- 1261

  Fly  1842 VSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLN 1906

Mouse  1262 ----------------------------------------------------------------- 1261

  Fly  1907 AGNVTGDGNHLNFHHPPATAGDKVEQATTKTS---VIKDKQLPPQQDDKDKKVVLPNEPARKLER 1968
                                        |||.   |::..:.|.
Mouse  1262 ----------------------------TKTEAPWVVESNRAPE--------------------- 1277

  Fly  1969 YQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVL 2033
                  .||.||.:.|.|.|:||....:.|:.|:|:.:..|:::||.||||:||||:.|.||.:|
Mouse  1278 ------GWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRIL 1336

  Fly  2034 QTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLK 2098
            :...|.|.||.:::..|...:||::|:|||||..||:.|:|.||||.|.:.:..:|..|||:.|.
Mouse  1337 EAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLN 1401

  Fly  2099 EFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAAD 2163
            .||:.. |.|||....:||.|||.|.|||:|||||:||.|..|||||||:.:|..|:..:.....
Mouse  1402 TFVSSQ-PAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIR 1465

  Fly  2164 LAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGL 2215
            ..|...|::||||||.||:||:|::|||:|.:.|..:|..| ...|.:|.|:
Mouse  1466 TQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNL-IAAGGIFYGM 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
Abcc3	NP_001350116.1	MRP_assoc_pro	7..1522	CDD:188098	506/2197 (23%)
Abcc3	NP_001350116.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..923		9/58 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010