Protein Alignment Sur and abcc12

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_009301629.1
• Gene: abcc12 / 568482
• ZFINID: ZDB-GENE-050517-25
• Length: 1368
• Species: Danio rerio
• Alignment Length: 2021
• Identity: 469/2021 - (23%)
• Similarity: 765/2021 - (37%)
• Gaps: 746/2021 - (36%)

  Fly   213 LDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEK 277
            :||.|          |:|.:.|.|:||::|..::..|: ||...:...|.|..:.:.|..::.|:
Zfish    69 VDDAG----------FFSFTSFSWMTPMMWRLFRNRLD-EDSLFLSPHDGAHINGERFQRLWDEE 122

  Fly   278 KKKSN-SSPSLWYCYIKNSWQMFALGGILKLAGDLFA---LIGP-LAIQKIVEYIEQLYAQASEP 337
            ..:.. ...||....::.....|.   :..||..:||   .:|| :.:.:|:.|:||     |||
Zfish   123 VARVGLEKASLSAVIMRFQKTRFI---VSFLASVMFAFAVFVGPSILVYEILNYVEQ-----SEP 179

  Fly   338 PAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGA 402
            .....|..|...|..      |||.:.|         ::|           :.|.|.|
Zfish   180 STVVHGVGVCVALFL------TEFSKAF---------FAS-----------VLWAVNL------- 211

  Fly   403 LSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMAT 467
                      .|.:|:|.:...|.::|.:.|.:              .|:.|
Zfish   212 ----------RTAVRVKGAFSMLAFKKIISLRS--------------LTTIT------------- 239

  Fly   468 PEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAV-VIYLLYMNLGISAVI 531
                           :|...|.:|.|...:.:..:...:...:|..:.: :||..:: ||.:|:|
Zfish   240 ---------------VGETINVLTSDGYRLFDAVIFGTFLLCVPVLLIICIIYACFI-LGYTALI 288

  Fly   532 GSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEAR 596
            | |...:|..|:||.|...:..........||:|::.:::.|..||:||:.||:|.|.|.|.:.|
Zfish   289 G-ILVYLIFLPIQFSIARLIGVFRRRAVSVTDKRVRTMNEVLTCIKLIKMYAWEESFEKSITDIR 352

  Fly   597 RKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVP 661
            :.|...|.|.....:|.:.||.|...|.|.||..|    |...:..|..|..::.:|:|..:.:.
Zfish   353 KNEKLLLQKAGYVQSLNSSLTTIVPTLATIVTFIV----HTSLKLPLLPSTAYTIIAVFNCMRMS 413

  Fly   662 LLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMR 726
            :.:.|.:|..:..|:|:..||:|.:.          ::|....|:: |.::|:....||:..:..
Zfish   414 MGLLPFSVKAVAEAKVALTRLKRIML----------VQNPKGYLTQ-DKNMDLALVMEKATFSWS 467

  Fly   727 TAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTP 791
            ....:|         .||.||..:      ||.:..||. .||                 |||
Zfish   468 PTDDKN---------TSQMPENPS------QNGKHKAES-QPS-----------------LRN-- 497

  Fly   792 YVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQ 856
                                                       |:::::
Zfish   498 -------------------------------------------ISLTLS---------------- 503

  Fly   857 LHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIR 921
                     ||.|..|.|..|||||||:|::|.:|.||:|::  ....|::|||||.|:.:.|:|
Zfish   504 ---------KGSLLGVCGNVGSGKTSLISSILEQMHLLSGSV--SANGTLAYVSQQAWIFHGTVR 557

  Fly   922 ENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANV 986
            :|||.||.|...||..|:.||.||||:.::|.||.:.|||||||:||||:||:::|||:||:.::
Zfish   558 DNILMGEPFDEARYASVINACCLKPDLAILPYGDQTEIGERGINLSGGQKQRVSLARAVYSNRDI 622

  Fly   987 VIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYA 1051
            .::||||:::|..||:|||:.||::.|:  .::.||||.||..::..:.::.:.:|.::..|:::
Zfish   623 FLLDDPLSAVDAHVGKHIFEECIKKELK--GKSVILVTHQLQYLEFCDEVMLLDNGEIKEAGTHS 685

  Fly  1052 DIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVAC 1116
            |:                              .||.|...:|:.||
Zfish   686 DL------------------------------MKTKGRYSQLITNV------------------- 701

  Fly  1117 HADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPID 1181
            |.:             |:|  |..|.
Zfish   702 HLE-------------QNN--ERADS--------------------------------------- 712

  Fly  1182 ECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAE 1246
                     :|:..|          |.|.:
Zfish   713 ---------KPQTEH----------NDSEQ----------------------------------- 723

  Fly  1247 SSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESP 1311
                                             .|...|.|..:.||....|:|
Zfish   724 ---------------------------------TNPDEPKANGIENPAFDMSDE----------- 744

  Fly  1312 LDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQ 1376
                                  ||        |||
Zfish   745 ----------------------KP--------ATN------------------------------ 749

  Fly  1377 SEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMP 1441
              |.||     ||.||                           :...::.|..|||.|
Zfish   750 --ETPK-----DSSET---------------------------KGKKDQLVTREVAQE------- 773

  Fly  1442 LARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCL---RVYTDIWLQQW------ 1497
                        |.::...|..|.:|||..|  :.|:..|::..|   ..:::.||..|
Zfish   774 ------------GSVTWRTYHQYCQAAGGYI--LLFLVVLLFTLLVGSTAFSNWWLSYWLDQGSG 824

  Fly  1498 -SNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKL 1561
             ::.....::.|::..:|     ::::|..:|..|....|:::::...........:...|||.:
Zfish   825 NNSSSNATSNSGNISENP-----DLSFYQMVYGVIIIAMIVLSILKGYTFTKVTLRSSSKLHDTM 884

  Fly  1562 LQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILV 1626
            .:.||...:.||..||.||:|||||.|...:|..:....:..|||.|:....:|....:.|::|:
Zfish   885 FKRILGSPMSFFDTTPTGRLVNRFSKDQDEVDAVLPFNMENFLQFCLIVTFTLLTICIVFPFLLI 949

  Fly  1627 LTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRL 1691
            ..:.:...:..|...::.|.|.::|:||.:.||.||..:.||||::||.|::::.::.| .||.|
Zfish   950 AVVILGLIFATILYVFQRSIRHMKRMENVSRSPWISLTTSTIQGLSTIHAYDKRQQYIE-RFKML 1013

  Fly  1692 -EANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFE 1755
             :.|:..:.|.|...|||...||.|.      ||||.:.:..|..                ||.|
Zfish  1014 SDNNSNHFMLFNAGTRWLSFWLDVLS------ATVTLIVSLFVVL----------------SPNE 1056

  Fly  1756 TYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADA 1820
            |.           :|||.|||::||:.:...|.:||:|..::|....||||:..|
Zfish  1057 TI-----------NPSLKGLALSYTIQLTGILQFVVRLSTEVEAKFTSVERLLEY---------- 1100

  Fly  1821 DADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGG 1885
                                                     .|:...:
Zfish  1101 -----------------------------------------ITSCVSE----------------- 1107

  Fly  1886 GDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQD 1950
               |.|:                                               :||
Zfish  1108 ---GPRR-----------------------------------------------VKD-------- 1114

  Fly  1951 DKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGIC 2015
                               .::|..|||.|.|.|.|.|:||......|:.||.:.|..|:::||.
Zfish  1115 -------------------ANIPAGWPQEGTITFKNYSMRYRDNTPIVLDNLNITIRPGEKLGIV 1160

  Fly  2016 GRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPH 2080
            |||||||||||::||.:.:...|.|.|||:||.::...:||::||:||||..||..|:|.||||.
Zfish  1161 GRTGSGKSSLGVALFRLAEPAEGTILIDDMDICKLGLKDLRSQLSVIPQDPVLFIGTVRYNLDPF 1225

  Fly  2081 GYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDE 2145
            ..::|.:||..||...:|:.:: .||..|.:.:.:.|.|.|.|.|||:|:|||:||.|..::|||
Zfish  1226 NNYKDEELWLALEKTYMKDTIS-KLPEKLQSPVVENGENFSVGERQLMCMARALLRNSKIILLDE 1289

  Fly  2146 ATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGS 2210
            ||:.:||.|:|.:.......|:..|::|||||:.|:|:.||::|:|||:::|...|::|.|...|
Zfish  1290 ATASIDSETDSLIQHTIRDGFQHCTMLTIAHRINTVLESDRILVMDQGKVIEFDPPQDLIQRPNS 1354

  Fly  2211 VFRGLL 2216
            :|..||
Zfish  1355 LFASLL 1360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	86/385 (22%)
		TM helix 1	301..324	CDD:350035	6/26 (23%)
		TM helix 2	385..433	CDD:350035	8/47 (17%)
		TM helix 3	480..525	CDD:350035	7/45 (16%)
		TM helix 4	526..575	CDD:350035	14/48 (29%)
		TM helix 5	587..631	CDD:350035	15/43 (35%)
		TM helix 6	648..681	CDD:350035	6/32 (19%)
		ABCC_MRP_domain1	837..1043	CDD:213217	82/205 (40%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	93/346 (27%)
		TM helix 1	1475..1496	CDD:350046	5/23 (22%)
		TM helix 2	1520..1568	CDD:350046	9/47 (19%)
		TM helix 3	1575..1620	CDD:350046	16/44 (36%)
		TM helix 4	1621..1670	CDD:350046	14/48 (29%)
		TM helix 5	1682..1727	CDD:350046	16/45 (36%)
		TM helix 6	1777..1810	CDD:350046	11/32 (34%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	98/220 (45%)
abcc12	XP_009301629.1	PLN03130	68..1364	CDD:215595	469/2021 (23%)