Protein Alignment Sur and abcc6a

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_009300481.1
• Gene: abcc6a / 566555
• ZFINID: ZDB-GENE-050517-18
• Length: 1507
• Species: Danio rerio
• Alignment Length: 2254
• Identity: 515/2254 - (22%)
• Similarity: 811/2254 - (35%)
• Gaps: 867/2254 - (38%)

  Fly    43 IFLLLFGLMFVCSRYKKCHKTLLTFHNGRAAISL-------LLLA--LNSFDLARIFL------- 91
            |:|.:....:....|  ||        ||..:.|       |||.  |.||.....|.
Zfish    42 IYLWVLSPFYCLHLY--CH--------GRGRLPLSSLCNAKLLLGFFLASFGFVEFFYILLERRL 96

  Fly    92 -PHQNVRNLNRLFQSSP--RDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKATVFLYAS 153
             .||::     :|..||  |.|                 |::..:.:::...|...:::|||:..
Zfish    97 EIHQHL-----VFLLSPIMRSL-----------------TVVLAVCVIHWERVRGCRSSVFLFFF 139

  Fly   154 TAVEALTFAL-------------LSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYK 205
            ..:..|...:             ||.::...:.:..:..||...:.:|  |....|.| |..|:|
Zfish   140 WLLGVLCSIIPLHAKVQLAVEQGLSPDIVRYLAFFSYFALQLAQLFLS--CFADQAPL-GKAVHK 201

  Fly   206 E-CYHDDYLDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDH 269
            . |...|              |:|.||..|||.:.|::.||:.||:.|||..::.||::......
Zfish   202 NACPVQD--------------ASFLSKILFWWFSGLIFKGYRSPLQAEDLWSLREEDTSERIISD 252

  Fly   270 FLYIYTEKK---------------------------KKSNSSPSLWYCYIKNSWQMFALGGILKL 307
            ....:|.|:                           :|.....|..:|.::...:.|   |...|
Zfish   253 LEEEWTAKRTKLQQQENHMSTSAALGSRLPDQAQLLRKIQKEQSSGFCLLRTLARSF---GPYFL 314

  Fly   308 AGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKV 372
            .|.|..::..:.:..:.:.:                          |.:||...||
Zfish   315 TGTLCLIVHDVFMFSVPQVL--------------------------SLLLGFMKDE--------- 344

  Fly   373 RIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADG 437
              .:..|     .|:..|.::.|.:..|...:...|:.....|:|:||::.||:|||||::|
Zfish   345 --DTPLW-----KGYFYATLMFLLSCLQSVFNHQYTYTCFTVGMRVKTAVMGLVYRKSLVMN--- 399

  Fly   438 GCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFL 502
                                                 |....:..:|.|.|.::.||:.:|:|.:
Zfish   400 -------------------------------------SSARRTCTVGEIVNLVSADTQKLMDFVV 427

  Fly   503 IIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLK 567
            ..:..|..|.::.:.::.|:.:||.||:.| ||.::.:.||..||....||..|:...|.|.|:|
Zfish   428 YFNAVWLAPIEVTLCLFFLWQHLGPSALAG-IATVIFIFPLNGFIARKRSKLQEIQMKYMDGRVK 491

  Fly   568 RIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVY 632
            .:::.|.|||::|..||::.||:::...|.||||.|.|....:::.....:.::.||.|...|||
Zfish   492 LMNEILNGIKILKFYAWEKAFLEQVLGYREKELKTLKKSQILYSVSLASFNSSSFLIAFAMFGVY 556

  Fly   633 VWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEG 697
            |.:  |.:..|:|.::|.|:||...|..||...|..:...:.|.||.:||.:||...|::..
Zfish   557 VLI--DDKNVLDAQKIFVSMALINILKTPLSQLPFAMSTTMQALVSLKRLGKFLCQDELKPD--- 616

  Fly   698 IRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEES 762
              |:||...|||..
Zfish   617 --NVARESFKSDVD--------------------------------------------------- 628

  Fly   763 AEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSL 827
                                                                             
Zfish   629 ----------------------------------------------------------------- 628

  Fly   828 LLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMP 892
                    .|..::|.|:|.......:.::.|.   ||.|.|..|||..||||:|||||:|.|..
Zfish   629 --------GVVFDNGTFSWSKDGPPCLKRISVK---VPCGSLVAVVGHVGSGKSSLLSAMLGETE 682

  Fly   893 LLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLS 957
            ..:|.:  ....:|:||.||.|:.|.::::|||||...:...|..|||||||.||::.:|.||.:
Zfish   683 KRSGTV--SVKGSIAYVPQQAWIQNASLQDNILFGREKKESWYQRVLEACALLPDLDNLPAGDAT 745

  Fly   958 IIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFIL 1022
            .|||:|:|:||||:||:::|||:|...:|.::||||:::|..||:|||...|.......::|.:|
Zfish   746 EIGEKGLNLSGGQKQRVSLARAVYRKGDVYLLDDPLSAVDAHVGQHIFNKVIGPKGILRDKTRVL 810

  Fly  1023 VTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTA 1087
            ||..:..:.:|:.::.:.||.:...|||.::
Zfish   811 VTHGMSFLPQADLILVLVDGEISERGSYQEL---------------------------------- 841

  Fly  1088 GERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNA 1152
                          |.|:         ...||.|....
Zfish   842 --------------LNRN---------GAFADFIHTFA--------------------------- 856

  Fly  1153 SCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLST 1217
                 |.:||                   ||..:.:           :||||   .|.|||
Zfish   857 -----NSERK-------------------ECFSEAL-----------QRGSR---KSVRLS---- 879

  Fly  1218 LTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNA 1282
                                                                  ||.:.|.||:.
Zfish   880 ------------------------------------------------------VTDYMPFSRDL 890

  Fly  1283 SSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNS 1347
            |.                                    :|.:
Zfish   891 SQ------------------------------------EQLI----------------------- 896

  Fly  1348 ILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANV 1412
                                 .|:.|....|..|      ||.|..|
Zfish   897 ---------------------GGDTNSIAIEPLP------DSDEDHI------------------ 916

  Fly  1413 TSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLP-IITIF 1476
               |.|                       |.:|....:.:.|::..::|:.|.|..||| ||:|.
Zfish   917 ---PED-----------------------LGKLTKVDKARIGRVKLEMYIEYFRTIGLPLIISIV 955

  Fly  1477 FITALIWQCLRVYTDIWLQQWSN----------------VHGRVASKGHVVLHPSEQDHEVTYYF 1525
            |:.| ..|...:..:.||..|::                |:|.:.....:.:            |
Zfish   956 FLYA-FQQAASLSNNYWLSLWADQPVINGTQLNTDLKLGVYGALGFAQGISI------------F 1007

  Fly  1526 RMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMA 1590
            ....|||..|||               |.|:||..||..:||..:.||:.||.|.::|||:.::.
Zfish  1008 GTTVAISLGCII---------------ASRHLHLDLLNNVLHSPMSFFESTPSGNLLNRFAKEID 1057

  Fly  1591 VIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENA 1655
            .||..|....:.:|.:........:|.:..||:..|:.||:...|..||.||..::.:|:|:|:.
Zfish  1058 AIDNMIPDGLKMMLSYFFKLTEVCIIVLMATPFAAVIILPMVFLYGFIQSFYVATSCQLRRLESV 1122

  Fly  1656 TNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIV 1720
            :.||:.:||:||:||.:.|||||:|:||......:::.|..||.....:.|||||:|::||..||
Zfish  1123 SRSPIYTHLNETVQGASVIRAFNEQSRFIMGANHKVDHNQTAYFPRFIATRWLGVNLEFLGNGIV 1187

  Fly  1721 FVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPI 1785
            ..|::.::.|....                                  ||.:||||::::|.|..
Zfish  1188 LAASILSVMAKGTL----------------------------------SPGMVGLAVSHSLQVTG 1218

  Fly  1786 YLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSS 1850
            :|:|:|:...|:|....||||:..||.
Zfish  1219 FLSWIVRSWTDVENNIVSVERVKEYAD-------------------------------------- 1245

  Fly  1851 QSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGN 1915
                                                                             
Zfish  1246 ----------------------------------------------------------------- 1245

  Fly  1916 HLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRG 1980
                                                      .|.|.|..:|. .|:|.||||.|
Zfish  1246 ------------------------------------------TPKEAAWSIEG-SSLPPSWPQTG 1267

  Fly  1981 DIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDV 2045
            .|.|.:..|:|....:..:..:::.|...::|||.||||:|||||.|.:|.:|:..:|.||||.:
Zfish  1268 TIEFQDYGLQYRKGLELALKGISVHIHEREKIGIVGRTGAGKSSLALGIFRILEAAKGEIYIDGI 1332

  Fly  2046 DIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLD 2110
            :|..|...:||:|::|||||..||:.::|.||||...:.|.::||.||||.||.||: .||..|:
Zfish  1333 NIAEIGLHDLRSRITIIPQDPVLFSGSLRMNLDPFNAYSDEEVWNALELAHLKNFVS-ELPDKLN 1396

  Fly  2111 TVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIA 2175
            ....:||.|||.|.|||:|||||:||.:..|||||||:.||..|::.:.......|....::|||
Zfish  1397 HECSEGGENLSLGQRQLVCLARALLRKTKVLVLDEATAALDLETDTLIQSTIRSQFEDCAVLTIA 1461

  Fly  2176 HRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLEKG 2219
            |||.||:||.::||:|:|.:||..:|..|....|..:....|.|
Zfish  1462 HRLNTIMDYTKVIVMDKGHVVEMDSPSNLIAKRGQFYYMCREAG 1505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
abcc6a	XP_009300481.1	MRP_assoc_pro	5..1506	CDD:188098	515/2254 (23%)
		ABC_membrane	317..584	CDD:279056	84/351 (24%)
		ABCC_MRP_domain1	630..831	CDD:213217	82/205 (40%)
		ABC_membrane	955..1218	CDD:279056	88/324 (27%)
		ABCC_MRP_domain2	1267..1487	CDD:213211	100/220 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.110