DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sur and abcc9

DIOPT Version :9

Sequence 1:NP_001334732.1 Gene:Sur / 34350 FlyBaseID:FBgn0028675 Length:2223 Species:Drosophila melanogaster
Sequence 2:XP_005164758.1 Gene:abcc9 / 561160 ZFINID:ZDB-GENE-050517-23 Length:1583 Species:Danio rerio


Alignment Length:2268 Identity:573/2268 - (25%)
Similarity:877/2268 - (38%) Gaps:795/2268 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 CGIDR---VRRVFTFFSIFLLLF-GLMFVCSRYKKCHKTLLTF--HNGRAAISLLLLALNSFDLA 87
            |.:|.   |..||..|..|.:|| |.....|:.:..|.|.|.|  ||.|..::..||.::..::|
Zfish    26 CFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNMRWILTFTLLFVHVCEIA 90

  Fly    88 RIFLPHQNVRNLNRLFQSSPRDLNYLV----VIGSGELWNALFSTLLTLMLMLY------HRMVE 142
            ...:.:..:.: |.|....|..:.::.    |:....:..|.|..|| |.|.:|      .:|::
Zfish    91 EGIVSNTQMES-NHLHLFMPAFMGFIAATTSVVYYHNIETANFPKLL-LALFIYWILAFITKMIK 153

  Fly   143 RKKATVFLYASTAVEALTFALLSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKE- 206
            ..|   |..||..|:.|.|                     |:.|:       |.:|.||.:..| 
Zfish   154 LWK---FAEASLGVQHLRF---------------------CITAL-------LVVLYGLLMAVEI 187

  Fly   207 ----------------CYHDDYLDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLG 255
                            ....:.|.|.| :.:........||:.:||:.||:...:|.|:||:.:|
Zfish   188 NVIRVRKYVFFANPQRVKPPEDLQDLG-VRFLQPFVNLLSKATYWWMNPLIIGAHKRPIELKKIG 251

  Fly   256 QMKLEDSARSHYDHFLYIYTEKKKKS---NSSPSLWYCYIKNSWQMFALGGIL-----KLAGDLF 312
            ::.:...|.::|......|.|:::.:   ..|||:|    |:.::.|. |.||     :...||.
Zfish   252 KLPIAMRALTNYLRLKDSYEEQRQNTEDPEKSPSIW----KSMYRAFG-GSILLSSTFRYMADLL 311

  Fly   313 ALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSS 377
            ...|||.|..|||::..                            .||.|....|......:|..
Zfish   312 GFAGPLCISGIVEHLHN----------------------------STEIDRTNKTGNMTFGVYFM 348

  Fly   378 TWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSS 442
            :.::||.|...:|.::.||.:.|....|||.::...|||.::.:|..:||.|.|.|:.     |:
Zfish   349 SSTELLQNTSVLAVLLFLALVLQRTFLQASYYVTIETGINLRGALLAMIYNKILRLST-----SN 408

  Fly   443 DSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYA 507
            .|.|::                                 .:|.|.|.:..:|..:|.|..:....
Zfish   409 MSMGEM---------------------------------TLGQINNLVAIETNQLMWFLFLCPNL 440

  Fly   508 WAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDT 572
            ||:|.:|.:.:.|||..||.||:||: ..|:::.|:|:.|...::...:....|:.:|||:..:.
Zfish   441 WAMPVQIIMGVILLYYLLGNSALIGA-GVILLLAPVQYLIATKLADIQKSTLDYSTDRLKKTTEI 504

  Fly   573 LVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTH----IATVLITFVTLGVYV 633
            |.|||::||.||:.:|..:::|.|.|||..| |.....|.|::..:    ||.||.||||   :.
Zfish   505 LKGIKLLKLYAWENIFCDRVEETRGKELTSL-KTFALHTSMSIFMNAAIPIAAVLATFVT---HA 565

  Fly   634 WLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGI 698
            ::..|:   |:.::.|:|||||..|..||.:....|...:.|.||.::|..||:|.||..  :..
Zfish   566 YIEEDR---LSPAKAFASLALFHILVTPLFLLSTVVRFAVKALVSVQKLSEFLQSDEIGD--DSW 625

  Fly   699 RNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESA 763
            ||....:|........|:...|         |.||....|                 :.|.|:..
Zfish   626 RNGDMCMSLEVGKKYKYQGDTK---------AINRKGRYR-----------------MDNYEQPV 664

  Fly   764 EDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLL 828
                               ||:|                    ||.|                  
Zfish   665 -------------------RRQL--------------------RPSE------------------ 672

  Fly   829 LKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPL 893
               .:|:||.:|||.|||...    :..|....|.:|.|:||::||:.|.||:|||.|:|.||..
Zfish   673 ---TEDVAVQVNDGFFTWGSN----LSTLSDINIRIPTGQLTMIVGQVGCGKSSLLLAMLGEMQT 730

  Fly   894 LAGNMFWHK--TC-------------------------TISYVSQQPWLLNDTIRENILFGESFR 931
            ::|.::|.|  .|                         :::|.:|:.||||.|:.|||.||..|.
Zfish   731 ISGKVYWSKLPDCEILFDGNISGHDMELSHEERSKNRYSVAYATQKSWLLNATVEENITFGSPFN 795

  Fly   932 PKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASL 996
            .:||..|::||:|:|||:|:|.||.:.|||||||:||||||||.:|||:|.:.|:|.:|||.::|
Zfish   796 KQRYKAVIDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSAL 860

  Fly   997 DNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRIT 1061
            |..:.:|:.|..|.:.||...||.:|||.:|..:..|:::||:|||.|...|:..||:.....:.
Zfish   861 DIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLIHADWIIAMKDGSVLREGTLKDIQTHDVELY 925

  Fly  1062 AEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGC 1126
                                       |.||.|                                
Zfish   926 ---------------------------EHWKTL-------------------------------- 931

  Fly  1127 ISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMR 1191
               .|.|...:|:|                                                   
Zfish   932 ---MNRQDQELEKD--------------------------------------------------- 942

  Fly  1192 PRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLAT 1256
                                                                             
Zfish   943 ----------------------------------------------------------------- 942

  Fly  1257 AAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQ 1321
                                                             |..||          |
Zfish   943 -------------------------------------------------TDLES----------Q 948

  Fly  1322 QFLRRMSMRR---SNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKK 1383
            ..|.|.::||   |.:.|||                             .|....|.:.||:.  
Zfish   949 TTLERKTLRRAFYSREAKNH-----------------------------VDDEDEEEEVEEED-- 982

  Fly  1384 CVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAID 1448
                         |||                                             ::..
Zfish   983 -------------DDN---------------------------------------------MSTT 989

  Fly  1449 TERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQW--SNVHGRV---ASKG 1508
            |.|: .||...:...|:.:.|..::.:...:.|....:.|..|.||..|  ||.|.:.   :|..
Zfish   990 TSRR-SKIPWKMCCCYLSSGGFLMVFLMVSSKLAKHSVMVAIDYWLAAWTSSNPHNQSFVNSSFN 1053

  Fly  1509 HVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFF 1573
            |.:...:.|..|...|..::..:....|.:.|:::...::.|..|..|||..||..|:|..:.||
Zfish  1054 HTLNDDATQIAEHRSYVPVFIILCAAAIALCLITSLTVEFLGVAAATNLHHNLLNKIIHAPIRFF 1118

  Fly  1574 QVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLI 1638
            .|||||:|:||||.|..:||:.|..|.:.|.:.||||||||.:...:||..|:..:|:..|:|.|
Zfish  1119 DVTPLGQILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGVIAFVTPAFLIALVPLAVAFYFI 1183

  Fly  1639 QKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNT 1703
            ||::|.::::||.::::|..|::.|.|||.:|:||||||..:.||.:.:.:..:.|..||..|:.
Zfish  1184 QKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHEARFKQRMLELTDTNNTAYLFLSA 1248

  Fly  1704 SHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRP 1768
            ::|||.|..||||..||..|.|.|:.            :||||                      
Zfish  1249 ANRWLEVRTDYLGAVIVLTAAVAAIW------------STSPS---------------------- 1279

  Fly  1769 SPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLD 1833
              .||||.:.|.|.:..||||||:.|||:|:...:|:::                          
Zfish  1280 --GLVGLGLTYALTLTNYLNWVVRNLADLEVQMAAVKKV-------------------------- 1316

  Fly  1834 HEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGA 1898
                 |..:|.|.:.          |.|:.    ||.:                           
Zfish  1317 -----NSFLSTESEN----------YEGSM----DVSQ--------------------------- 1335

  Fly  1899 EANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPA 1963
                                                                             
Zfish  1336 ----------------------------------------------------------------- 1335

  Fly  1964 RKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLS 2028
                    ||..|||.|:|...::.:||:...:.|:.::...|..||::|||||||||||||.|:
Zfish  1336 --------VPEDWPQHGEITIHDLCVRYDSMLKPVLKHVNAHINPGQKVGICGRTGSGKSSLSLA 1392

  Fly  2029 LFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLE 2093
            .|.::....|.|.||.:||.::....||:|||||.||..||:.:||.||||.....|.:||..||
Zfish  1393 FFNMVDVFEGKIVIDGIDICKLPLQTLRSRLSIILQDPVLFSGSIRLNLDPERTCTDDRLWEALE 1457

  Fly  2094 LAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESAL 2158
            :||||..|.. ||.|||.|:.:||.|.|.|.|||.|||||.:|.|..|::||||:.:|.:||:.|
Zfish  1458 IAQLKNMVKA-LPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENIL 1521

  Fly  2159 LKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLL 2216
            .|....||..||::||||.:::||:.::::|...|.:||:.:...|...|.|:| |:|
Zfish  1522 QKVVMTAFADRTVVTIAHLVSSILEAEQVLVFSSGILVENDSAINLLAQEDSLF-GIL 1578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SurNP_001334732.1 None
abcc9XP_005164758.1 CFTR_protein 223..1575 CDD:273530 520/2031 (26%)
ABC_membrane 304..591 CDD:294371 98/360 (27%)
ABCC_SUR1_N 678..907 CDD:213257 97/232 (42%)
ABC_membrane 1045..1300 CDD:294371 100/290 (34%)
ABCC_SUR2 1269..1583 CDD:213255 142/493 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 178 1.000 Domainoid score I3516
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H56521
Inparanoid 1 1.050 783 1.000 Inparanoid score I502
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
44.060

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