Protein Alignment Sur and abcc10

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_021335425.2
• Gene: abcc10 / 556709
• ZFINID: ZDB-GENE-050517-24
• Length: 1548
• Species: Danio rerio
• Alignment Length: 2254
• Identity: 492/2254 - (21%)
• Similarity: 793/2254 - (35%)
• Gaps: 889/2254 - (39%)

  Fly    71 RAAISLLLLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVI--GSGEL-WNALFSTLLTL 132
            |||.:||:..|...||..:             |:....|: ||..:  |.|.| :...|..:|:|
Zfish    75 RAASTLLVFLLFIGDLVLV-------------FELQAPDI-YLDTLADGCGILAFLVHFGAILSL 125

  Fly   133 MLMLYHRMVERKKATVFLYASTAVEALTFALLSNELFELVRYEDFLELQTCLVAMS----AMCMV 193
            ...:|.|  .|..|.:.:....::..|.|.|.:... |::.:.....||...:|.:    |:.:|
Zfish   126 QKSIYRR--TRGPALLPVALILSIPNLAFNLTAYTQ-EIIHHGVSQPLQVIRLAFTVTRGALVLV 187

  Fly   194 SLAMLDGLTVYKECYHD--DYL--------------DDYGKIGYKHSMATFYSKSCFWWLTPLLW 242
            .|     |.....||..  |.|              :.:.::......::..|:..:.||.|||.
Zfish   188 YL-----LGYIFPCYRTQRDLLSCNAEDEAPLIVTFEPFEEVTVAEDGSSLLSRLLYLWLNPLLN 247

  Fly   243 LGYKEPLE-----LEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSP------SLWYCYIKNSW 296
            .|.:..||     .|...:::.:...|..|..:......:..|....|      :|.    .|||
Zfish   248 RGKRGELERPSDVFELPSRLRTKSVTRRFYQCWEKCLQSRALKRPERPDRRPRGNLQ----DNSW 308

  Fly   297 -----------------------------QMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYA 332
                                         :.:.||| |||...:.|..|||.:..:|.::|
Zfish   309 SEAQPERICEGEAEHEVKLLQVLHKAFGLRYYLLGG-LKLVASMLAFAGPLLLGGLVGFME---- 368

  Fly   333 QASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWI---VL 394
                                      ||     |..:.|             ..||...:   ..
Zfish   369 --------------------------TE-----GAPLSK-------------GVWCTVGLFASTF 389

  Fly   395 LAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQ 459
            |||:    |.....:.::...:..:.::...||.|:|.:||
Zfish   390 LAAL----LKNIFVYEVSKVALEARAAVISTIYSKALKVNA------------------------ 426

  Fly   460 KNDDSMATPEHVDNPSEPNISH-DIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYM 523
                             |:::. ::|.:.|.|:.||..::.||...|..|::||:..:.:||||:
Zfish   427 -----------------PSLARFNMGEVVNFMSTDTDRVVNFFNSFHEVWSLPFQFVLALYLLYL 474

  Fly   524 NLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVF 588
            .:|: |.:|.:...|::.||...:.:.:.:|.:.:..:.|.|:|.:.:.|.||:|:|...|:|.|
Zfish   475 QVGV-AFLGGVGVAVLLVPLNKVLASRILENNKHMLQHKDGRVKLMTEILFGIRVLKYYNWEEHF 538

  Fly   589 LKKIQEARRKE------LKYLNKDATF-WTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNAS 646
            .:||:|||:||      ||||:....: |..:.|:..|.| .||:|.||          .:|.|:
Zfish   539 TQKIEEARKKELHHLKLLKYLDAVCVYTWAALPVVISILT-FITYVLLG----------NNLTAA 592

  Fly   647 RLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDAS 711
            ::||:|||...|.:||..||..:...:.|:||..|::||                   |:..|..
Zfish   593 KVFSTLALVGMLILPLNAFPWVLNGTLEAKVSLDRIQRF-------------------LAVQDQD 638

  Fly   712 LDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGH 776
            |.:|.:|                                          ...|| .||.||
Zfish   639 LSVYYSQ------------------------------------------VCPED-PPSAVQ---- 656

  Fly   777 NKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSIND 841
              :||                           ..||..::...||       :.:||||.   .:
Zfish   657 --MVQ---------------------------ASFSWKQSEEADS-------VSIPDDIT---EE 682

  Fly   842 GLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWH-KTCT 905
            |.   .|.|    ..||...:.|.:|.|.:||||.|.||:|||:|:..|:....|.:|.. :...
Zfish   683 GS---PPHS----FYLHALNLNVKRGSLVVVVGKVGCGKSSLLAAITGELTRCGGEVFVQGREQG 740

  Fly   906 ISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQ 970
            .....|:||:.:.|:::|||||..:....|..|::||||..|:.::|.||.:.:||.|:.:||||
Zfish   741 FGLAVQEPWIQHATVQDNILFGRDYDNMFYQSVIQACALADDLNILPGGDQTEVGENGVTLSGGQ 805

  Fly   971 RQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEY 1035
            :.|:|:|||:|....:.::|||||::|.:|..|:.:.||..:|:  ::|.||.|.::..:.:|:.
Zfish   806 KSRLALARAVYMDKEIYLLDDPLAAVDADVAHHLMEKCILGILK--DKTRILCTHRIEFVDKADV 868

  Fly  1036 LIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKL 1100
            ::.:.:|.:...|:        |      :|::::.|...|:                 ||
Zfish   869 VVLMDNGMIVKTGT--------P------SAVLSLVKGPKDS-----------------KN---- 898

  Fly  1101 GLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSS 1165
                                            .||..|:|            |.|
Zfish   899 --------------------------------SSNAKEKD------------SAG---------- 909

  Fly  1166 IYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGD 1230
                                                                             
Zfish   910 ----------------------------------------------------------------- 909

  Fly  1231 VLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDV 1295
                                                                             
Zfish   910 ----------------------------------------------------------------- 909

  Fly  1296 KKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVH 1360
                                                                             
Zfish   910 ----------------------------------------------------------------- 909

  Fly  1361 FPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNER 1425
                            |||                     ..||:.||:|.:
Zfish   910 ----------------SEE---------------------MEASEPELKAEL------------- 924

  Fly  1426 HVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYT 1490
                |:.||.              :::.|.:|..:|..|.:|.|..:.....:...:.|..:..:
Zfish   925 ----EMFGEE--------------QKQMGTLSWAVYRSYWKAVGGCMAVAVLLALFLMQASKNVS 971

  Fly  1491 DIWLQQW-----SNVHGRVA------------SKGHVVLHPS--------EQDHEVTYYFRMYAA 1530
            |.||..|     .|:...|:            |.|.:|.:.|        ....|:.:|..:|.:
Zfish   972 DWWLSHWISHMKDNMTELVSVSATPLLMLSFLSPGRLVFNASARGSESSGNMSSELKFYMTVYGS 1036

  Fly  1531 ISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKK 1595
            ::....:..........|....|...:|.:||.::|..|:.||..||||||:||||:|:..:|..
Zfish  1037 LAAANTVFTAARAFLFAYGAICAATVIHKRLLSSVLKATMTFFDTTPLGRILNRFSSDIYSVDDS 1101

  Fly  1596 IAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPV 1660
            :......||......|..:::.....||:|:..:|:...||..|.|||.|:|||:|:.:.|.|||
Zfish  1102 LPFVLNILLANVFGLLGMLIVMSYGLPWVLLPLVPLGALYYQTQCFYRYSSRELKRLCSLTLSPV 1166

  Fly  1661 ISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATV 1725
            .||.|||:.|::|:||....|||.|...:|||.|.......|.:.:||.:.|..:        .|
Zfish  1167 YSHFSETLSGLSTVRASGHTTRFEEENERRLEQNQRCLFNSNAAMQWLDIRLQMI--------AV 1223

  Fly  1726 TALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRP-SPSLVGLAINYTLLVPIYLNW 1789
            |.:|..||                         :.....:|:. .|.||||:::|.|.:...|:.
Zfish  1224 TVVTGISV-------------------------IAVIQHQLKSIDPGLVGLSLSYALSITNLLSG 1263

  Fly  1790 VVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDA 1854
            ::...|..||...|:||...|:
Zfish  1264 LIFSYAQTEMQLVSIERTEEYS------------------------------------------- 1285

  Fly  1855 GDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNF 1919
                                                                             
Zfish  1286 ----------------------------------------------------------------- 1285

  Fly  1920 HHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPIS--WPQRGDI 1982
                             ||:                   |.||     :..|:.:|  ||:|..:
Zfish  1286 -----------------TSI-------------------PQEP-----QQASLEVSDRWPERARV 1309

  Fly  1983 HFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDI 2047
            .|.:|.|.|.....|.:..:::::..|::|||.||||||||||.|:||.:::..:|.|.:|.|||
Zfish  1310 EFVDVVLSYRPGLPNALDGVSVEVLPGEKIGIVGRTGSGKSSLFLALFRMVELNQGQILLDGVDI 1374

  Fly  2048 QRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFV--NGHLPLGLD 2110
            ..:|..:||::|:|||||..||::::||||||||...|.:|...||...|...|  ||    |||
Zfish  1375 SSVRLSDLRSKLAIIPQDPFLFSSSVRENLDPHGRHPDYRLLEALEQCHLGNVVQRNG----GLD 1435

  Fly  2111 TVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIA 2175
            :.:.:.|.:||.|.|||||||||:|..:..|.:||||:.:|..|:..|.|.....|:.:|::|||
Zfish  1436 SEVGERGKSLSVGQRQLLCLARALLTEANILCIDEATASVDQKTDMLLQKTIREKFKDKTVLTIA 1500

  Fly  2176 HRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLEKG 2219
            |||.||:|.|:::|:..|::||..:|..|.|.|.|.|:.||..|
Zfish  1501 HRLNTIMDSDKVLVMHAGKVVEFDSPATLCQREDSAFQKLLRGG 1544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	97/391 (25%)
		TM helix 1	301..324	CDD:350035	10/22 (45%)
		TM helix 2	385..433	CDD:350035	10/50 (20%)
		TM helix 3	480..525	CDD:350035	15/45 (33%)
		TM helix 4	526..575	CDD:350035	11/48 (23%)
		TM helix 5	587..631	CDD:350035	20/50 (40%)
		TM helix 6	648..681	CDD:350035	13/32 (41%)
		ABCC_MRP_domain1	837..1043	CDD:213217	70/206 (34%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	98/361 (27%)
		TM helix 1	1475..1496	CDD:350046	4/20 (20%)
		TM helix 2	1520..1568	CDD:350046	9/47 (19%)
		TM helix 3	1575..1620	CDD:350046	15/44 (34%)
		TM helix 4	1621..1670	CDD:350046	24/48 (50%)
		TM helix 5	1682..1727	CDD:350046	12/44 (27%)
		TM helix 6	1777..1810	CDD:350046	9/32 (28%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	97/222 (44%)
abcc10	XP_021335425.2	None