Protein Alignment Sur and ABCB4

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_011514610.3
• Gene: ABCB4 / 5244
• HGNCID: 45
• Length: 1384
• Species: Homo sapiens
• Alignment Length: 1451
• Identity: 254/1451 - (17%)
• Similarity: 446/1451 - (30%)
• Gaps: 633/1451 - (43%)

  Fly   832 PDDIA--VSINDGLFTWQPQSQMPVVQ-LHVPGIIVPKGKLTIVVGKNGSGKTSLLSAL------ 887
            ||.|.  :..||..|::..::.:.::: |::.   |..|:...:||.:|.||::.:..:
Human   477 PDSIKGNLEFNDVHFSYPSRANVKILKGLNLK---VQSGQTVALVGSSGCGKSTTVQLIQRLYDP 538

  Fly   888 -------------------LMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGES---- 929
                               |.|:              |..|||:|.|.:.||.|||.:|..
Human   539 DEGTINIDGQDIRNFNVNYLREI--------------IGVVSQEPVLFSTTIAENICYGRGNVTM 589

  Fly   930 -------FRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVV 987
                   .....|:|:::          :|:...:::||||..:||||:||||||||:..:..::
Human   590 DEIKKAVKEANAYEFIMK----------LPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKIL 644

  Fly   988 IMDDPLASLDNEVGEHIFQHCIREMLQKS--NRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSY 1050
            ::|:..::||.|....     ::..|.|:  .||.|::..:|..::.|:.:...:||.:...||:
Human   645 LLDEATSALDTESEAE-----VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSH 704

  Fly  1051 ADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVA 1115
            :  |||                            |..|..:||: |:...|.|
Human   705 S--ELM----------------------------KKEGVYFKLV-NMQTSGSQ------------ 726

  Fly  1116 CHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPI 1180
                            :||...|.:|:.:.:                |.:..|.:..::
Human   727 ----------------IQSEEFELNDEKAAT----------------RMAPNGWKSRLF------ 753

  Fly  1181 DECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYA 1245
                          ||:.    .:|..:|.                             .|....
Human   754 --------------RHST----QKNLKNSQ-----------------------------MCQKSL 771

  Fly  1246 ESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSES 1310
            :...||                            ..|:.||.
Human   772 DVETDG----------------------------LEANVPPV----------------------- 785

  Fly  1311 PLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEE--SPPVVHFPASILATDGNKN 1373
                       .||:.:.:.::      ..|.....::.:|:..  .|......:.|:|..|..:
Human   786 -----------SFLKVLKLNKT------EWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGD 833

  Fly  1374 ETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRE 1438
            :.   .|.:||              |.:|.
Human   834 DA---VKQQKC--------------NIFSL----------------------------------- 846

  Fly  1439 SMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGR 1503
                                 |:|.      |.||:.|
Human   847 ---------------------IFLF------LGIISFF--------------------------- 857

  Fly  1504 VASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHK 1568
                              |::.:.:.               .|: ||....|.|.....:.:|.:
Human   858 ------------------TFFLQGFT---------------FGK-AGEILTRRLRSMAFKAMLRQ 888

  Fly  1569 TLHFF--QVTPLGRIVNRFSNDMAVIDKKIAATGQR--LLQFTLLCLSAILINVTITPWILVLTL 1629
            .:.:|  .....|.:..|.:.|.|.:.   .|||.|  |:...:..|...:|...|..|.|.|.|
Human   889 DMSWFDDHKNSTGALSTRLATDAAQVQ---GATGTRLALIAQNIANLGTGIIISFIYGWQLTLLL 950

  Fly  1630 ----PICGAYYLIQ-KFYRCSA-RELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILF 1688
                ||.....::: |....:| |:.:.:|.|...     .:|.|:.:.|:.:..|:.:|..:..
Human   951 LAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKI-----ATEAIENIRTVVSLTQERKFESMYV 1010

  Fly  1689 KRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSP 1753
            ::|      |.....|     |...::.| |.|..:...:..:...|.|
Human  1011 EKL------YGPYRNS-----VQKAHIYG-ITFSISQAFMYFSYAGCFR---------------- 1047

  Fly  1754 FETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADA 1818
            |..|.:.......| ...||..||.:                      |:| .:.|      |.:
Human  1048 FGAYLIVNGHMRFR-DVILVFSAIVF----------------------GAV-ALGH------ASS 1082

  Fly  1819 DADADADADVDAD-----LDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRI 1878
            .|...|.|.:.|.     .:.:|.        :|  |.|:.|.|
Human  1083 FAPDYAKAKLSAAHLFMLFERQPL--------ID--SYSEEGLK--------------------- 1116

  Fly  1879 GGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDK 1943
                                   .||.. ||:|
Human  1117 -----------------------PDKFE-GNIT-------------------------------- 1125

  Fly  1944 QLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPA 2008
                                     :..|..::|.|.::              .|:..|:|::..
Human  1126 -------------------------FNEVVFNYPTRANV--------------PVLQGLSLEVKK 1151

  Fly  2009 GQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYI-------DDVDIQRIRPDELRTRLSIIPQDV 2066
            ||.:.:.|.:|.|||::...|........|.:::       |..:.:::....||.:|.|:.|:.
Human  1152 GQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEP 1216

  Fly  2067 HLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGH-----LPLGLDTVICDGGLNLSAGHRQ 2126
            .||:.:|.||:   .|..:.::.:..|:....:..|.|     ||...:|.:.|.|..||.|.:|
Human  1217 ILFDCSIAENI---AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQ 1278

  Fly  2127 LLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLD 2191
            .:.:|||::|....|:||||||.||:.:|..:.:|.|.|..|||.|.|||||:||.:.|.::|..
Human  1279 RIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQ 1343

  Fly  2192 QGRIVEDGNPRELQQLEGSVF 2212
            .||:.|.|..::|...:|..|
Human  1344 NGRVKEHGTHQQLLAQKGIYF 1364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
ABCB4	XP_011514610.3	AAA	108..1369	CDD:333001	254/1451 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910