Protein Alignment Sur and LOC4576815

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_061506268.1
• Gene: LOC4576815 / 4576815
• VectorBaseID: AGAMI1_013414
• Length: 1406
• Species: Anopheles gambiae
• Alignment Length: 2026
• Identity: 454/2026 - (22%)
• Similarity: 747/2026 - (36%)
• Gaps: 708/2026 - (34%)

  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSPSLWYC 290
            |:|.||..||||..:...|.::.:..|.|.....|.|:....:.|..:::|::::..:..|....
Mosquito    19 ASFLSKRSFWWLREMFRYGQRKEITEEKLYATLPEHSSHGLAETFERLWSEEEQRGPTKASFARV 83

  Fly   291 YIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSR 355
            |    |:.|  |......|.:|:                         |....|.||..||
Mosquito    84 Y----WRAF--GKETLFWGLVFS-------------------------AFETANRVAQPLL---- 113

  Fly   356 ILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTH----ILNMTGI 416
             || |....|..|.|.:....             |::..:..|....||..|.|    .:...|:
Mosquito   114 -LG-ELVSYFTPNQDTISERD-------------AYLYAIGVIACSLLSVISFHPFIFFIFQLGM 163

  Fly   417 RIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISH 481
            :.:.....|||.|.|.|:      .|.:||                |.:.
Mosquito   164 KFRIGASCLIYNKVLKLS------KSTTAG----------------DGLN--------------- 191

  Fly   482 DIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFF 546
              |.|.|.::.|..........:|..|..|.:..::.|.:|..:|.|.::| :|.::...|||.:
Mosquito   192 --GKIINLLSNDVGKFDIALCFVHDLWKGPMEAVLLGYFIYCQIGFSGLLG-MAFLMSFIPLQAW 253

  Fly   547 IGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWT 611
            :|...:......|..||.|::.:::.:.||:|||:..|:..|.|.|:..||||::.:...|
Mosquito   254 VGKKTATYRMKAAKRTDVRVRFMNEIIQGIQVIKMYTWESSFAKMIENIRRKEIQAIRGGA---- 314

  Fly   612 LMAVLTHIATVLITFVT---LGVYVWL--HRDQEFDLNASRLFSSLALFQQLTVPLLIF-PITVP 670
                  ::...||:|.|   :.:::.|  :...|..:.|.::|...:.:..|...::.| |:.:.
Mosquito   315 ------YVRATLISFFTVSRVSIFISLLSYTVTENVITAKKVFIVTSFYSILNDSMVHFWPMAIT 373

  Fly   671 IIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLN 735
            ......:|.:|:..||.:.|               .||..|.:|....:|...|..|:..:|
Mosquito   374 FCAEGYISLKRIRDFLLTPE---------------GKSSLSTNMPSDVKKGKKTTSTSDKDN--- 420

  Fly   736 EKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKM 800
                  .||.               ||::.|....:|.                         ..
Mosquito   421 ------SSQM---------------ESSKGIKEDALQN-------------------------GS 439

  Fly   801 RGSVMERPVEFSVIR----ARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPG 861
            :|......|:|..:.    .|..|..|:           .:.:::....|...|.:||..:...|
Mosquito   440 KGVTKNEDVDFEPLLPKRFVRTVDGERK-----------GIVLDNATARWMCPSAVPVGAISTMG 493

  Fly   862 -------------------IIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTIS 907
                               :.|..|:|.::||..||||::||..||.|:.|..|.:..:.  |:|
Mosquito   494 KGGGDCSEETTNVGIESVSLTVDPGRLCVLVGPVGSGKSTLLQVLLGELELDQGTVEMYG--TVS 556

  Fly   908 YVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQ 972
            |.:|:|||...::|.||:|.|.:..:||..|:..|||:.|.||.|.||.:|:|||||::||||:.
Mosquito   557 YAAQEPWLYEGSVRNNIIFTEEYDERRYLRVVRVCALEKDFELFPHGDQTIVGERGISLSGGQKA 621

  Fly   973 RIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLI 1037
            |:.:|||||..|::.::||||:::|..||:|||:.|||:.|  :||..:|||.||..:|:.:.::
Mosquito   622 RVNLARAIYRKADIYLLDDPLSAVDTHVGKHIFELCIRDFL--ANRVCVLVTHQLQYLKDVQQIV 684

  Fly  1038 AIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGL 1102
            .:..|||||||||.:::        :.|....||...:::|.::|.||....|.....:.|..|.
Mosquito   685 LMNAGRVEACGSYKELK--------KSNIESIMALTPDESPLESPIEKELKNRRPRRTSGSSTGS 741

  Fly  1103 QRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIY 1167
            ||...:.||                        ::::|.|.......|.:...|.::.:...|.
Mosquito   742 QRDSDLMMD------------------------LLQQDKQEEEKESQGGSGSVGLSVYKTYFSA- 781

  Fly  1168 GSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVL 1232
                                                  .||...:..||.|.           ||
Mosquito   782 --------------------------------------VNSCGWVFWLSALM-----------VL 797

  Fly  1233 SRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKK 1297
            |:.|            |.|.|:..|    ...:|:           .:.|..||..::
Mosquito   798 SQIV------------VSGVDIFVA----EWVNWE-----------EKVAGIPPEFDL------- 828

  Fly  1298 SEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFP 1362
                                                   |.:|.:.::..:..:..|...|.:|
Mosquito   829 ---------------------------------------NDNHTILSSRDVRILLREQADVSNF- 853

  Fly  1363 ASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHV 1427
                                                                  .:::|:
Mosquito   854 ------------------------------------------------------IERQQY----- 859

  Fly  1428 LAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDI 1492
                                            |::.    :||.|:.:..:.
Mosquito   860 --------------------------------IWIY----SGLIILLVILVV------------- 875

  Fly  1493 WLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNL 1557
                                     ....::::        ||:.:::               ||
Mosquito   876 -------------------------QRSFSFFY--------VCLRISI---------------NL 892

  Fly  1558 HDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITP 1622
            ||:|.:.:...|::||...|.|||:||||.|:..||..:.......:.|.|..::.:.:...:..
Mosquito   893 HDRLFRGLTRATMYFFNTNPSGRILNRFSKDIGAIDSALPMALLDCVVFFLEMIAVVAVVSIVNY 957

  Fly  1623 WILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEIL 1687
            |.||.|..:....|.|::.|..::|.::|||:...||:.||.:.|:||::|||||..|:......
Mosquito   958 WFLVPTAVVAVVMYYIRQTYLNTSRVVKRIESVNRSPLFSHTNATLQGLSTIRAFGAQSILKHEF 1022

  Fly  1688 FKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPS 1752
            .:.|:.|:.|:.:..::.|...:.||.:  |::::..:|.
Mosquito  1023 NEFLDVNSSAWYMFISTSRAFALWLDVV--CVLYIGIITI------------------------- 1060

  Fly  1753 PFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDAD 1817
               ::.|..|...|..|   |||||..|:.:.....|.::..|::|....||||:..|
Mosquito  1061 ---SFLVGNSNQMLGGS---VGLAITKTISLVGMCQWGMRQSAELENQMVSVERVNEY------- 1112

  Fly  1818 ADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGAR 1882
                        .:|..||
Mosquito  1113 ------------TNLPSEP---------------------------------------------- 1119

  Fly  1883 GGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPP 1947
                                                   |..||
Mosquito  1120 ---------------------------------------PLETA--------------------- 1124

  Fly  1948 QQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRI 2012
                          |..:.:|      :||:.|.|.|:||.|||....:.|:.:|...|.:.:::
Mosquito  1125 --------------PKHRPQR------NWPEHGTIRFNNVDLRYSDDGERVLKDLNFTIRSNEKV 1169

  Fly  2013 GICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENL 2077
            ||.||||:|||||..:||. |....|:|.|||:|.:.:...:||:::||||||..||:.|:|.||
Mosquito  1170 GIVGRTGAGKSSLIQALFR-LAPFEGNIEIDDIDTKTLGLRDLRSKISIIPQDPILFSGTLRSNL 1233

  Fly  2078 DPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLV 2142
            ||....:|.:||:.|:..:|||.|:. |..||:..:.|||.|.|.|.|||:||||||||.:..||
Mosquito  1234 DPFDQRKDDELWSALDQVELKEAVSS-LAGGLECRMSDGGSNFSMGQRQLVCLARAILRNNKILV 1297

  Fly  2143 LDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQL 2207
            |||||:.:|..|:..:.......|...|::||||||.|::|.||::|:|.||:||.|:|.||  |
Mosquito  1298 LDEATANVDPETDKLIQTTIRTKFAHCTVLTIAHRLNTVMDSDRVLVMDAGRVVEFGHPHEL--L 1360

  Fly  2208 EGSVFRGLLEK 2218
            .|.:  |.|.:
Mosquito  1361 HGPI--GYLRR 1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	79/390 (20%)
		TM helix 1	301..324	CDD:350035	3/22 (14%)
		TM helix 2	385..433	CDD:350035	12/51 (24%)
		TM helix 3	480..525	CDD:350035	9/44 (20%)
		TM helix 4	526..575	CDD:350035	12/48 (25%)
		TM helix 5	587..631	CDD:350035	12/46 (26%)
		TM helix 6	648..681	CDD:350035	5/33 (15%)
		ABCC_MRP_domain1	837..1043	CDD:213217	84/224 (38%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	72/335 (21%)
		TM helix 1	1475..1496	CDD:350046	0/20 (0%)
		TM helix 2	1520..1568	CDD:350046	7/47 (15%)
		TM helix 3	1575..1620	CDD:350046	13/44 (30%)
		TM helix 4	1621..1670	CDD:350046	16/48 (33%)
		TM helix 5	1682..1727	CDD:350046	7/44 (16%)
		TM helix 6	1777..1810	CDD:350046	9/32 (28%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	103/220 (47%)
LOC4576815	XP_061506268.1	None