Protein Alignment Sur and LOC4397657

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_061510127.1
• Gene: LOC4397657 / 4397657
• VectorBaseID: AGAMI1_001984
• Length: 1504
• Species: Anopheles gambiae
• Alignment Length: 2242
• Identity: 522/2242 - (23%)
• Similarity: 810/2242 - (36%)
• Gaps: 852/2242 - (38%)

  Fly    40 FFSIFLLLFGLMFVCSRYK-------KCHKTLLTFHNGRAAISLLLLALNSFDLARIFLPHQNVR 97
            |..:|.:...|..|.|||:       ...|.:.||         .|:.::..||..:      |:
Mosquito    41 FLFVFSMYEVLRIVTSRYRDIPWNWFNITKMIFTF---------ALMVMSWVDLGVV------VQ 90

  Fly    98 NLNRLFQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKATVFLY-----ASTAVE 157
            ||:   :....|:..||.|     :|||...:...:...|.:...|...|:|::     ....::
Mosquito    91 NLD---EPEVFDVQILVAI-----FNALAYIMAMALYFFYRKYGIRSTGTMFIFWFLKAFFGIIQ 147

  Fly   158 ALTFALLSNELFELVRYE---DFLELQ--TCLVAMSAMCMVSLAML--DGLTVYKECYHDDYLDD 215
            ..|.|:|.:     ||..   ||.|.|  :..:..:.:|.|.|..|  |....|.|
Mosquito   148 MRTEAMLHD-----VRGSGTGDFAEFQFVSYTIQYTFVCCVLLLELFPDKEPRYSE--------- 198

  Fly   216 YGKIGYKHS--MATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARS---HYDHFLYIYT 275
            :.|:...:.  .::|:|:..:.:.....|.|:::||..:|:..:..||::|:   .:|.:.|...
Mosquito   199 WAKLKNPNPELRSSFFSRLFYLYFDSYAWRGFRKPLTDDDMYDLNPEDTSRALVPPFDKYWYESV 263

  Fly   276 EK-------------------KKKSNSSPSLWYCYIKNSWQMFALGGILKLAGDL-FALIG---- 316
            ||                   |..:.::.|:....:|      |.||....||.| ||:.|
Mosquito   264 EKGRRKQIAADKKAGKTNLVYKPNAATNGSVLPAMVK------AYGGPFWFAGMLQFAISGLQFA 322

  Fly   317 -PLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWS 380
             |..:|:|:..|      |.:.|                                       .|
Mosquito   323 SPYLMQEIMAVI------ALDGP---------------------------------------FW- 341

  Fly   381 DLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSA 445
                .|..|...:.|.::.....:....|...:.|.||:|.|...||||:|.:::....|::
Mosquito   342 ----KGMIITLGLFLTSLLIALFNGQYFHRTFLVGFRIRTGLISAIYRKALRISSFAKKDTT--- 399

  Fly   446 GQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAI 510
                                                 :|.|.|.|..|.:...|....:|..|:.
Mosquito   400 -------------------------------------VGEIVNLMAVDAQRFFELTSYLHVLWSA 427

  Fly   511 PFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVG 575
            |..||:.|||||..|| .||...:..:|||.|:..||...|...........|||:|::::.|.|
Mosquito   428 PLIIALCIYLLYELLG-PAVFAGLGVMVIMIPITGFIATRMRDLQVEQMKIKDERVKKMNEILGG 491

  Fly   576 IKVIKLNAWDEVFLKKIQEARRKELKYLNKDATF-------WTLMAVLTHIATVLITFVTLGVYV 633
            |||:||.||:..|...:...|.:||..|...|.:       ||:       |..|:|..:..|||
Mosquito   492 IKVLKLYAWEPSFQDTVVTVRNEELDVLKSAAYYGAGTYFVWTM-------APFLVTLASFAVYV 549

  Fly   634 WLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGI 698
            .:  |:|..|:....|.:||||..|..||.:||:.:...:.|.||.:|:::|:.|.|:
Mosquito   550 MI--DEENVLDPQTAFVALALFNILRFPLAMFPMMITFAMQAWVSIKRIDKFMNSEEL------- 605

  Fly   699 RNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESA 763
                                :.:|:|
Mosquito   606 --------------------DPNNVT--------------------------------------- 611

  Fly   764 EDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLL 828
                        |||
Mosquito   612 ------------HNK-------------------------------------------------- 614

  Fly   829 LKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPL 893
                .:.|:.:.||.|:|...:.    .|....:.:.:|||:.|||..|:||:||:||||.||..
Mosquito   615 ----SENALEVKDGTFSWGDDAP----TLKNINLALRRGKLSAVVGGVGTGKSSLISALLGEMEK 671

  Fly   894 LAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSI 958
            :.|::  :...:|:||.||.|:.|.|:|:|||||..|...:||.|:|.|||:||:|::|.||.:.
Mosquito   672 MKGSV--NTDGSIAYVPQQAWIQNATLRDNILFGRPFDQAKYDKVIECCALRPDLEMLPGGDTTE 734

  Fly   959 IGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILV 1023
            |||:|||:||||:||:|:|||:|:.:.|.:.||||:::|..||:|||:..|........|:.:||
Mosquito   735 IGEKGINLSGGQKQRVALARAVYADSEVYLFDDPLSAVDAHVGKHIFEKVIGPSGMLVGRSRLLV 799

  Fly  1024 TQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAG 1088
            |..:..:...|.:..:|||.|...|||.:: |.|....||:
Mosquito   800 THGISFLPFVEEIFVMKDGEVSESGSYQEL-LDQKGAFAEF------------------------ 839

  Fly  1089 ERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNAS 1153
                                     :..|...:|.              |::|::.:
Mosquito   840 -------------------------LTQHIQEMDD--------------EDEDELKL-------- 857

  Fly  1154 CGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTL 1218
                                      |.|...|                    ..:.::...:..
Mosquito   858 --------------------------IQEALKD--------------------GEAKKIVQRAMS 876

  Fly  1219 TATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNAS 1283
            |.:..|.|.:|.|..:.|      |.|||
Mosquito   877 TRSQRSGSSNGSVRKKRV------SRAES------------------------------------ 899

  Fly  1284 SPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSI 1348
                                                          |.||||:.....::..:|.
Mosquito   900 ----------------------------------------------RNSNKPRAVEQTVAQQSSA 918

  Fly  1349 LSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVT 1413
            ..|.:|
Mosquito   919 TLIEKE----------------------------------------------------------- 924

  Fly  1414 SSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAG--LPIITIF 1476
                                                |...|.:...:|:.|.:..|  |...:||
Mosquito   925 ------------------------------------ESATGAVGYVVYIKYFKGIGLWLGFWSIF 953

  Fly  1477 FITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAI---SCVCIIM 1538
            |  ::|.|...:|.:|||..||       ........||.:|    .|..:|..:   ..:.:::
Mosquito   954 F--SVINQGASIYANIWLTDWS-------EDPEAATDPSVRD----MYLGVYGGLGGAQSIALLI 1005

  Fly  1539 ALVSTPAGQYAGC-NARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQR 1602
            |.|:..    .|| .|.|.||:.||::.:...:.||..||||||:||||.|:.|:|..:.   |.
Mosquito  1006 ASVTLA----LGCIKAARELHNNLLESSMRMPMSFFDTTPLGRIMNRFSKDVDVVDNILP---QS 1063

  Fly  1603 LLQFTLLCLSAILINVTI---TPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHL 1664
            :..:.|:..:.|.:.|.|   ||..|.:.......||||||||..::|:|:|:|:.|.||:.||.
Mosquito  1064 IRAWLLMFFNVIGVFVVIGISTPIFLAVVPAFLVIYYLIQKFYIATSRQLKRLESVTRSPIYSHF 1128

  Fly  1665 SETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALT 1729
            .|:|.|.:||||:.||.||.....:|::.|.:.......::|||.|.|:.:|..:||.|.:.|:.
Mosquito  1129 GESITGQSTIRAYGQQERFMNESEQRVDYNQLTSYPSIIANRWLAVRLELVGALVVFFAALFAMV 1193

  Fly  1730 AA-SVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKL 1793
            |. |:.     :||                              |||:|:|.|.:...|:::|::
Mosquito  1194 ARDSIG-----QAT------------------------------VGLSISYALQISATLSFLVRM 1223

  Fly  1794 LADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKV 1858
            .|::|....::||:..|
Mosquito  1224 TAEVETNIVAIERLEEY------------------------------------------------ 1240

  Fly  1859 YPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPP 1923
                                                                             
Mosquito  1241 ----------------------------------------------------------------- 1240

  Fly  1924 ATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVS 1988
                                            .|||.|...:|..   |..:||..|.:.|.:..
Mosquito  1241 --------------------------------TVLPREAEWQLGH---VDKAWPVEGKVEFKDYQ 1270

  Fly  1989 LRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPD 2053
            :||......||..::|.:..|::|||.||||:|||||.|.||.:::...|.|.||.:||.::...
Mosquito  1271 IRYREGLDLVIRGISLNVRGGEKIGIVGRTGAGKSSLTLGLFRIVEAAGGQIIIDGLDISKMGLH 1335

  Fly  2054 ELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGL 2118
            :||.||:|||||..||:.|:|.|:||...:.|..:|..|||:.||.||.| |..|||..|.:.|.
Mosquito  1336 QLRGRLTIIPQDPVLFSGTLRANVDPFKSYSDDLVWKALELSHLKTFVKG-LAAGLDHEIAENGE 1399

  Fly  2119 NLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILD 2183
            |||.|.|||:|||||:||.:..|:|||||:.:|..|:..:.|.....|...||:||||||.||||
Mosquito  1400 NLSVGQRQLICLARAVLRKTKVLILDEATAAVDLETDDLIQKTIRTEFADCTILTIAHRLNTILD 1464

  Fly  2184 YDRLIVLDQGRIVEDGNPRELQQLEGSVFRGL 2215
            .||::|||:|.:.|..:|:.|.....|:|.|:
Mosquito  1465 SDRVLVLDKGLVAECDSPQNLLANRESIFFGM 1496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	100/393 (25%)
		TM helix 1	301..324	CDD:350035	10/28 (36%)
		TM helix 2	385..433	CDD:350035	14/47 (30%)
		TM helix 3	480..525	CDD:350035	16/44 (36%)
		TM helix 4	526..575	CDD:350035	15/48 (31%)
		TM helix 5	587..631	CDD:350035	11/50 (22%)
		TM helix 6	648..681	CDD:350035	13/32 (41%)
		ABCC_MRP_domain1	837..1043	CDD:213217	87/205 (42%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	105/343 (31%)
		TM helix 1	1475..1496	CDD:350046	9/20 (45%)
		TM helix 2	1520..1568	CDD:350046	12/51 (24%)
		TM helix 3	1575..1620	CDD:350046	17/44 (39%)
		TM helix 4	1621..1670	CDD:350046	22/48 (46%)
		TM helix 5	1682..1727	CDD:350046	13/44 (30%)
		TM helix 6	1777..1810	CDD:350046	9/32 (28%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	104/220 (47%)
LOC4397657	XP_061510127.1	None