Protein Alignment Sur and ABCC1

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_016878726.1
• Gene: ABCC1 / 4363
• HGNCID: 51
• Length: 1549
• Species: Homo sapiens
• Alignment Length: 2233
• Identity: 524/2233 - (23%)
• Similarity: 828/2233 - (37%)
• Gaps: 824/2233 - (36%)

  Fly    38 FTFFSIFLLLFGLMFVCSRYKKCHKTLLTFHNGRAAISLLLLALNSFDLARIFLPHQNVRNLNRL 102
            |.|:.::|         ||:.:.:..:...:..:.|:..||..:...||...|........|..:
Human    68 FPFYFLYL---------SRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPV 123

  Fly   103 FQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKA--------TVFLYASTAVEAL 159
            |..||      .::|            :|::|..:...:||:|.        |.:|.|.....|:
Human   124 FLVSP------TLLG------------ITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAI 170

  Fly   160 TFALLSNELFELVRYEDFLELQTCLVAMSAMC--MVSLAMLDGLTVYKECYHDDYLDDYGKIGYK 222
            ..:.:...|.|..:.:.|.:: |..|..|.:.  :|.....|...::.|..||..       ...
Human   171 LRSKIMTALKEDAQVDLFRDI-TFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPN-------PCP 227

  Fly   223 HSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDS----------------ARSHYDHFL 271
            .|.|:|.|:..|||:|.|:..||::|||..||..:..||:                |::......
Human   228 ESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVK 292

  Fly   272 YIYTEK----KKKSNS-------------------SPSLWYCYIKNSWQMFALGGILKLAGDLFA 313
            .:|:.|    .|:|:.                   :|||:....|.....|.:....|...||..
Human   293 VVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMM 357

  Fly   314 LIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSST 378
            ..||..::.:::::..         .|:|                                   .
Human   358 FSGPQILKLLIKFVND---------TKAP-----------------------------------D 378

  Fly   379 WSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSD 443
            |     .|:....::.:.|..|..:.....||..::|:||||::.|.:|||:|::        ::
Human   379 W-----QGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVI--------TN 430

  Fly   444 SAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAW 508
            ||.:    |||                            :|.|.|.|:.|.:..|:....|:..|
Human   431 SARK----SST----------------------------VGEIVNLMSVDAQRFMDLATYINMIW 463

  Fly   509 AIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGY--TDERLKRIHD 571
            :.|.::.:.:|||::|||.| |:..:|.:|:|.|:...:  ||......:|..  .|.|:|.:::
Human   464 SAPLQVILALYLLWLNLGPS-VLAGVAVMVLMVPVNAVM--AMKTKTYQVAHMKSKDNRIKLMNE 525

  Fly   572 TLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIAT-VLITFVTLGVYVWL 635
            .|.||||:||.||:..|..|:...|::|||.|.|.| :.:.:...|.:.| .|:...|..|||.:
Human   526 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSA-YLSAVGTFTWVCTPFLVALCTFAVYVTI 589

  Fly   636 HRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRN 700
              |:...|:|...|.|||||..|..||.|.|:.:..|:.|.||.:||..||
Human   590 --DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFL-------------- 638

  Fly   701 MARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAED 765
                                                                         |.|:
Human   639 -------------------------------------------------------------SHEE 642

  Fly   766 ISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLK 830
            :.|.:::.                      ||.|..|               .|:|
Human   643 LEPDSIER----------------------RPVKDGG---------------GTNS--------- 661

  Fly   831 MPDDIAVSINDGLFTWQPQSQMPVVQLHVPGII--VPKGKLTIVVGKNGSGKTSLLSALLMEMPL 893
                  :::.:..||| .:|..|.:.    ||.  :|:|.|..|||:.|.||:|||||||.||..
Human   662 ------ITVRNATFTW-ARSDPPTLN----GITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDK 715

  Fly   894 LAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSI 958
            :.|::....  :::||.||.|:.||::|||||||.......|..|::||||.||:|::|.||.:.
Human   716 VEGHVAIKG--SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTE 778

  Fly   959 IGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILV 1023
            |||:|:|:||||:||:::|||:||:|::.:.||||:::|..||:|||::.|.......|:|.|||
Human   779 IGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILV 843

  Fly  1024 TQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQN-PGEKTA 1087
            |..:..:.:.:.:|.:..|::...|||.:: |.:....||:....|..:.:.|..... .|....
Human   844 THSMSYLPQVDVIIVMSGGKISEMGSYQEL-LARDGAFAEFLRTYASTEQEQDAEENGVTGVSGP 907

  Fly  1088 GERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNA 1152
            |:..|.::|        .:.||..|
Human   908 GKEAKQMEN--------GMLVTDSA---------------------------------------- 924

  Fly  1153 SCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLST 1217
               |..|||:.||
Human   925 ---GKQLQRQLSS---------------------------------------------------- 934

  Fly  1218 LTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNA 1282
                  |||.|||:
Human   935 ------SSSYSGDI--------------------------------------------------- 942

  Fly  1283 SSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNS 1347
                                                                  :.||     ||
Human   943 ------------------------------------------------------SRHH-----NS 948

  Fly  1348 ILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANV 1412
                          .|.:...:..|.||.      |.:..|..:|
Human   949 --------------TAELQKAEAKKEETW------KLMEADKAQT-------------------- 973

  Fly  1413 TSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFF 1477
                                                     |::...:|..|::|.||   .|.|
Human   974 -----------------------------------------GQVKLSVYWDYMKAIGL---FISF 994

  Fly  1478 ITALIWQCLRV---YTDIWLQQWSN---VHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCI 1536
            ::..::.|..|   .::.||..|::   |:|             .|:| ......:|.|:.....
Human   995 LSIFLFMCNHVSALASNYWLSLWTDDPIVNG-------------TQEH-TKVRLSVYGALGISQG 1045

  Fly  1537 IMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQ 1601
            |.....:.|....|..|.|.||..||.:||...:.||:.||.|.:|||||.::..:|..|....:
Human  1046 IAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK 1110

  Fly  1602 RLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSE 1666
            ..:......:.|.::.:..||...::..|:...|:.:|:||..|:|:|:|:|:.:.|||.||.:|
Human  1111 MFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNE 1175

  Fly  1667 TIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAA 1731
            |:.||:.||||.:|.||......:::.|..||.....::|||.|.|:.:|.|||..|.:.|:.:
Human  1176 TLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVIS- 1239

  Fly  1732 SVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLAD 1796
                 ||       |.||                     .||||:::|:|.|..||||:|::.::
Human  1240 -----RH-------SLSA---------------------GLVGLSVSYSLQVTTYLNWLVRMSSE 1271

  Fly  1797 MEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPG 1861
            ||....:|||:..|::
Human  1272 METNIVAVERLKEYSE------------------------------------------------- 1287

  Fly  1862 ATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATA 1926
                                                                             
Human  1288 ----------------------------------------------------------------- 1287

  Fly  1927 GDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRY 1991
                          .:|:.|.|..:                  .:.|.||||.|.:.|.|..|||
Human  1288 --------------TEKEAPWQIQE------------------TAPPSSWPQVGRVEFRNYCLRY 1320

  Fly  1992 EGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELR 2056
            ......|:.::.:.|..|:::||.||||:|||||.|.||.:.::..|.|.||.::|.:|...:||
Human  1321 REDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLR 1385

  Fly  2057 TRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLS 2121
            .:::|||||..||:.::|.||||...:.|.::|..||||.||:||:. ||..||....:||.|||
Human  1386 FKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSA-LPDKLDHECAEGGENLS 1449

  Fly  2122 AGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDR 2186
            .|.|||:|||||:||.:..|||||||:.:|..|:..:.......|...|::||||||.||:||.|
Human  1450 VGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTR 1514

  Fly  2187 LIVLDQGRIVEDGNPRELQQLEG 2209
            :||||:|.|.|.|.|.:|.|..|
Human  1515 VIVLDKGEIQEYGAPSDLLQQRG 1537

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.110