Protein Alignment Sur and Mrp5

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Alignment Length: 2032
• Identity: 453/2032 - (22%)
• Similarity: 729/2032 - (35%)
• Gaps: 774/2032 - (38%)

  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYI----YTEKKKKSNSSPS 286
            :..:|...|.:..|..:.|.|:.|:..|| ...|::....|....|..    ..|||:|...:||
  Fly    17 SNIFSSLMFCFAMPTFFKGRKKTLDENDL-YRALQEHRSDHLGSKLSAAWEKEVEKKRKKKKTPS 80

  Fly   287 LWYCYIKNS-----WQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEV 346
            |    :|.|     |::..||.:|.:....|.:..||.:..:|.|    ||.||...
  Fly    81 L----LKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAY----YADASNQE-------- 129

  Fly   347 ANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTH-- 409
                               |.|..|..:|:                  |..|...|.:....|
  Fly   130 -------------------GDNQTKAYLYA------------------LGVILTSACNVLFMHPY 157

  Fly   410 ILNM--TGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVD 472
            :|.|  .|::.:.::..:||||:|.|:.....|:  :.|||.:.
  Fly   158 MLGMFHIGMKARIAMTSMIYRKALRLSRTALGDT--TIGQVVNL--------------------- 199

  Fly   473 NPSEPNISHDIGSITNHMTEDTRNIMEFFLIIH--YAWAIPFKIAVVIYLLYMNLGISAVIGSIA 535
                  ||:|:|.:.             ..:||  |.|..|.:|.::.||:|..:||||..| :|
  Fly   200 ------ISNDVGRLD-------------VSVIHMNYLWLGPVEIGIITYLMYREIGISAFFG-VA 244

  Fly   536 CIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKEL 600
            .:::..|||.::|...|......|..||||::.:::.:.||:|||:.||:..|.|.|...|.||:
  Fly   245 VMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEM 309

  Fly   601 KYLNK----DATFWTLMAVLTHIATV--LITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLT 659
            ..:..    ..|..:.:..:|.|:..  |:.||.||..          |.|.:.|...|.:..|.
  Fly   310 NAIRNVNYIRGTLQSFIMFVTRISVFVSLVGFVLLGKL----------LTAEKAFVITAYYNILR 364

  Fly   660 VPLLI-FPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNM 723
            ..:.: ||:.:.......||.||::.|:...|           .::..||:
  Fly   365 NTMTVYFPMGISQFAELLVSIRRIQTFMLHEE-----------TKVRDKSE-------------- 404

  Fly   724 TMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLR 788
                     .|:|::|.:.....|                    |:..|..|
  Fly   405 ---------DLDEQKLGKAGLIAE--------------------PTVAQTTG------------- 427

  Fly   789 NTPYVAIRPPKMRGSVMERPVEFSVIRA----RNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQ 849
                 .::|...|.|..|..:..|.::|    :|||: ..|::.||               ::|:
  Fly   428 -----VLKPSSRRTSEAEHSIVISKLKAKWDQKNTDN-TLDNISLK---------------FKPR 471

  Fly   850 SQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPW 914
                              :|..|:|..||||:||:.|:|.|:...:|::  ....|:||.||:||
  Fly   472 ------------------QLVAVIGPVGSGKSSLIQAVLGELNPDSGSV--KVNGTLSYASQEPW 516

  Fly   915 LLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARA 979
            |...|:|:|||||......||..|::.|||:.|.||:|..|.:|:||||.::||||:.||::|||
  Fly   517 LFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARA 581

  Fly   980 IYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRV 1044
            :|..|::.::||||:::|..||.|:|..|:|..|::  ...:|||.||..:::|:.::.:..|::
  Fly   582 VYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLRE--EIVLLVTHQLQFLEQADVIVIMDKGKI 644

  Fly  1045 EACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVT 1109
            .|.|:|                                            ::::|.||
  Fly   645 SAMGTY--------------------------------------------ESMAKSGL------- 658

  Fly  1110 MDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMY 1174
                              ..|.|
  Fly   659 ------------------DFAQM------------------------------------------ 663

  Fly  1175 DVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLAT 1239
                                                       ||..|:....:||.
  Fly   664 -------------------------------------------LTDPSKKDEGAGDA-------- 677

  Fly  1240 SCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRS 1304
                                                                 || |||
  Fly   678 -----------------------------------------------------PD-KKS------ 682

  Fly  1305 NTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSIL-SISEESPPVVHFPASILAT 1368
                                   ..|:::|.::.|..:|:..|.. |::.|||
  Fly   683 -----------------------LSRQNSKLRDRHGSISSMESAAESLAAESP------------ 712

  Fly  1369 DGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAG 1433
                  .|::|
  Fly   713 ------MQTQE------------------------------------------------------ 717

  Fly  1434 ESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWS 1498
              ||..              |:|...:|..|..|.|..:..:|....:..|.|....||:|..|.
  Fly   718 --GRVE--------------GRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWV 766

  Fly  1499 NVHGRVASKGHVV----LHP-----SEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNAR 1554
            |.:|.......:.    ..|     ::.|....|||   ..|:...||.:||.:....|....:.
  Fly   767 NKNGEAERDTFMARLRRAFPETRINADTDPVDIYYF---TGINVSVIIFSLVRSMLFFYLAMRSS 828

  Fly  1555 RNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVT 1619
            ..||:.:.|.:....:|||...|.|||:||||.|:..:|:.:.:....::|..|..:..:::...
  Fly   829 TTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCI 893

  Fly  1620 ITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFT 1684
            |..|.::.|:.:...:||::.||..::|:::|:|..|.||:.||||.::.|:.|||||..|....
  Fly   894 INVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELI 958

  Fly  1685 EILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASA 1749
            .......:.::..|.:...:.|..|..||.:  |:|::|.:|.
  Fly   959 AEFDNYQDMHSSGYYMFLATSRAFGYWLDCV--CVVYIAVITL---------------------- 999

  Fly  1750 SPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQ 1814
               .|..:    ||.    :...|||||...:.:...:.|.::..|::|....:|||:..|
  Fly  1000 ---SFFLF----SPE----NGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEY---- 1049

  Fly  1815 DADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIG 1879
                                     ||:..|.|..|
  Fly  1050 -------------------------EDLEPEGDFES----------------------------- 1060

  Fly  1880 GARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQ 1944
                                                                         |..:
  Fly  1061 -------------------------------------------------------------KPNK 1064

  Fly  1945 LPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQK--QNVISNLTLKIP 2007
            .||    ||                      ||:.|.|.||::||:|...|  ..|:.:|.:.|.
  Fly  1065 KPP----KD----------------------WPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIE 1103

  Fly  2008 AGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNAT 2072
            ..:::||.||||:|||||..:||. |....|.|.||..|...:...:||:::|||||:..||:.|
  Fly  1104 GCEKVGIVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGT 1167

  Fly  2073 IRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRG 2137
            :|.||||...:.|.:||..||..:||:.| ..||.||.:.|.:||.|.|.|.|||:||||||||.
  Fly  1168 MRYNLDPFDEYSDAKLWESLEEVKLKQVV-ADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRE 1231

  Fly  2138 SVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPR 2202
            :..||:||||:.:|..|::.:.......|:..|::||||||.|::|.|:::|:|.|:.||.|:|.
  Fly  1232 NRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPF 1296

  Fly  2203 E-LQQLEGSVFRGLLEK 2218
            | |...|..||..::::
  Fly  1297 ELLTTSEKKVFHSMVKQ 1313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	93/393 (24%)
		TM helix 1	301..324	CDD:350035	6/22 (27%)
		TM helix 2	385..433	CDD:350035	12/51 (24%)
		TM helix 3	480..525	CDD:350035	12/46 (26%)
		TM helix 4	526..575	CDD:350035	16/48 (33%)
		TM helix 5	587..631	CDD:350035	13/49 (27%)
		TM helix 6	648..681	CDD:350035	7/33 (21%)
		ABCC_MRP_domain1	837..1043	CDD:213217	74/205 (36%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	85/344 (25%)
		TM helix 1	1475..1496	CDD:350046	6/20 (30%)
		TM helix 2	1520..1568	CDD:350046	12/47 (26%)
		TM helix 3	1575..1620	CDD:350046	12/44 (27%)
		TM helix 4	1621..1670	CDD:350046	16/48 (33%)
		TM helix 5	1682..1727	CDD:350046	8/44 (18%)
		TM helix 6	1777..1810	CDD:350046	7/32 (22%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	99/222 (45%)
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	438/1969 (22%)