Protein Alignment Sur and Mrp4

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Alignment Length: 2008
• Identity: 451/2008 - (22%)
• Similarity: 728/2008 - (36%)
• Gaps: 754/2008 - (37%)

  Fly   230 SKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSPSLWYCYIK- 293
            |...|.:..|:|:.|.|:.||.:||.:...|..:.|..|.....:.|:..| |.:|.|.....|
  Fly    21 SSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAK-NETPRLGRALTKV 84

  Fly   294 NSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILG 358
            ..:.:|..|..|.....|..:..|:.:..::.|.      |...|.:|...     |.:...|.|
  Fly    85 FGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYF------AGNDPDRSKAQ-----LWAAGLIAG 138

  Fly   359 TEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQ 423
            :.|..                        ||....:|..:          |:    |::::.:|.
  Fly   139 SVFSV------------------------CIGHPYMLGLL----------HL----GMKMRIALS 165

  Fly   424 GLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITN 488
            .|||||:|.|:.....|::                                        :|.:.|
  Fly   166 SLIYRKALRLSRTALGDTT----------------------------------------VGQVVN 190

  Fly   489 HMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSK 553
            .::.|........:.:||.|..|.::..|.||:|:.:|||::.| :|.:::..|.|.::|...|.
  Fly   191 LLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFG-VAIMLLFLPFQSYLGKRTSV 254

  Fly   554 NAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEAR------RKELKYLNKDATFWTL 612
            .....|..||||::.:::.:.||:|||:.||::.|.|.::..|      .|::.|:......:.:
  Fly   255 LRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAM 319

  Fly   613 MAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPL-LIFPITVPIIIAAR 676
            .......::.||.||.||..          |||.:.|...|.:..|...: :.||..:.......
  Fly   320 FLSRIFTSSSLIAFVLLGNI----------LNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELL 374

  Fly   677 VSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQ 741
            ||.||||.|:...|.:     :|:.:::                                |...|
  Fly   375 VSVRRLEAFMHRPETK-----VRDKSKV--------------------------------KNANQ 402

  Fly   742 KSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVME 806
            |:::|           |.:.                                    ||..| :.|
  Fly   403 KAESP-----------NGDS------------------------------------PKGNG-IPE 419

  Fly   807 RPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTI 871
            ..:|||..:||    |...||...:.|     ||              :||       .:.||..
  Fly   420 NLIEFSQFQAR----WESHSLEPTLED-----IN--------------LQL-------GRRKLVA 454

  Fly   872 VVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYD 936
            |:|..|:||:||:.|:|.|:|..:|.:  ....:.||.:|:|||...|:|:|||||..:...||.
  Fly   455 VIGPVGAGKSSLIQAILGELPGESGTL--RINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYR 517

  Fly   937 FVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVG 1001
            .|::.|||:.|.||:|.||.:|:||||.::||||:.||::|||:|..|::.::||||:::|..||
  Fly   518 TVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVG 582

  Fly  1002 EHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNA 1066
            .|:|..|:|..|:  :...||||.||..:::|:.::.:..||:.|.|:|:
  Fly   583 RHLFDQCMRGYLR--SELVILVTHQLQFLEQADLIVIMDKGRISAMGTYS--------------- 630

  Fly  1067 IIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVAN 1131
                                         ::.:.||..:..:|.....|...|.|||:|
  Fly   631 -----------------------------SMKRSGLDFAQLLTAPNKDAEDLDEIDGAG------ 660

  Fly  1132 MQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGD--DVIMRPRR 1194
                                                                 ||  |::..|
  Fly   661 -----------------------------------------------------GDGLDLLNVP-- 670

  Fly  1195 RHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAP 1259
              :|.||||:|:..|.|.:..                       ||.||.|||
  Fly   671 --SLSRRGSKNSKPSTRNNSF-----------------------TSLSSMAES------------ 698

  Fly  1260 EPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFL 1324
                                                 .::||
  Fly   699 -------------------------------------MAQEA----------------------- 703

  Fly  1325 RRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDS 1389
                                                                         ::..
  Fly   704 -------------------------------------------------------------SLQM 707

  Fly  1390 KETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYG 1454
            :||.:.                                                          |
  Fly   708 QETRVE----------------------------------------------------------G 714

  Fly  1455 KISDDIYLMYIRAAGLPIITIFFIT--ALIWQCLRVYTDIWLQQW--SNVHGRVASKGHVVLHPS 1515
            ||...:|..|: .:|.....|||:.  .|..|.|....|.:|..|  .||.|:..      ::..
  Fly   715 KIGLGLYKEYL-TSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTD------INTD 772

  Fly  1516 EQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGR 1580
            .||   .|||   ||::...::..:|.|.........:...||:.:.|.|....::||...|.||
  Fly   773 PQD---MYYF---AALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGR 831

  Fly  1581 IVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCS 1645
            |:||||.|:..:|:.:.:....::|..|..|..|::.....|:.|:|||.:...:|.|::||..:
  Fly   832 ILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKT 896

  Fly  1646 ARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGV 1710
            :|:::|:|....||:.||||.||.|:.||||...|...........:.::..|.....::|..|.
  Fly   897 SRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGY 961

  Fly  1711 SLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGL 1775
            .||..  |.:::..:..                            .|.:  :|.:   ||..|||
  Fly   962 YLDCF--CTLYIVIIIL----------------------------NYFI--NPPQ---SPGEVGL 991

  Fly  1776 AINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNE 1840
            ||...:.:...:.|.::..|::|....:|||:..|
  Fly   992 AITQAMGMTGMVQWAMRQSAELENTMTAVERVVEY------------------------------ 1026

  Fly  1841 DVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKL 1905
                           |::.|     .|:.|.                   |:|
  Fly  1027 ---------------DEIEP-----EGEFDS-------------------REG------------ 1040

  Fly  1906 NAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQ 1970
                                                 |:..|
  Fly  1041 -------------------------------------KKPSP----------------------- 1045

  Fly  1971 SVPISWPQRGDIHFDNVSLRY--EGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVL 2033
                |||::|:|..:::.|||  :.|.:.|:..|..:|...:::||.||||:|||||..:||. |
  Fly  1046 ----SWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFR-L 1105

  Fly  2034 QTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLK 2098
            ....|.|.||:.|...:...:||:::|||||:..||:.::|.||||...:.|.:||:.||..:||
  Fly  1106 SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLK 1170

  Fly  2099 EFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAAD 2163
            ..:: .||.||.:.|.:||.|.|.|.|||:||||||||.:..||:||||:.:|..|::.:.....
  Fly  1171 PLIS-ELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIR 1234

  Fly  2164 LAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRE-LQQLEGSVFRGL-LEKG 2219
            ..||..|::||||||.||:|.||::|:|.|.:||.|:|.| |...|..:|.|: :|.|
  Fly  1235 SKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETG 1292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	80/387 (21%)
		TM helix 1	301..324	CDD:350035	4/22 (18%)
		TM helix 2	385..433	CDD:350035	12/47 (26%)
		TM helix 3	480..525	CDD:350035	11/44 (25%)
		TM helix 4	526..575	CDD:350035	14/48 (29%)
		TM helix 5	587..631	CDD:350035	10/49 (20%)
		TM helix 6	648..681	CDD:350035	7/33 (21%)
		ABCC_MRP_domain1	837..1043	CDD:213217	78/205 (38%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	88/339 (26%)
		TM helix 1	1475..1496	CDD:350046	8/22 (36%)
		TM helix 2	1520..1568	CDD:350046	11/47 (23%)
		TM helix 3	1575..1620	CDD:350046	14/44 (32%)
		TM helix 4	1621..1670	CDD:350046	20/48 (42%)
		TM helix 5	1682..1727	CDD:350046	6/44 (14%)
		TM helix 6	1777..1810	CDD:350046	7/32 (22%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	98/222 (44%)
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	450/2006 (22%)