DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sur and abcc2

DIOPT Version :9

Sequence 1:NP_001334732.1 Gene:Sur / 34350 FlyBaseID:FBgn0028675 Length:2223 Species:Drosophila melanogaster
Sequence 2:NP_956883.2 Gene:abcc2 / 393561 ZFINID:ZDB-GENE-040426-1523 Length:1567 Species:Danio rerio


Alignment Length:2268 Identity:508/2268 - (22%)
Similarity:810/2268 - (35%) Gaps:865/2268 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 LLFGLMFVCSRY---KKCHKTL-----LTFHNGRAAISLLLL---ALNSFDLARIFLPHQNVRNL 99
            |....:::||.:   ..|.|:.     ..::..:....||||   |..:..|...|.|       
Zfish    38 LPLAFLWICSPFHFRSFCQKSAKAPASALYYCKQVVAGLLLLTAVAELAVTLGEDFGP------- 95

  Fly   100 NRLFQSSPRDL--NYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKATVFLYASTAVEALTFA 162
                 ||..|.  |..|:..:..|:...:..::.....:.||::.....::|::....|....|.
Zfish    96 -----SSDEDAQKNPAVLYTNPVLFAVSWIVVMLCQESMRHRLMCVDSGSLFMFWLLQVVCAVFQ 155

  Fly   163 L-------LSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDDYLDDYGKIG 220
            .       ||..:.::.|:        ||..:|....:...:|..:.        |...:..|:.
Zfish   156 FQTLLREALSQGISDVPRF--------CLFYISYGLQIIALVLSAIA--------DVSPEAKKVA 204

  Fly   221 YKH--SMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHF------------- 270
            ..:  :.|||.|:..|.|...::|.|:|.||..||:..:...||.     ||             
Zfish   205 ETNPEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMWDLNKNDST-----HFICQTFEDVMAKEL 264

  Fly   271 ----------------------------------LYIYTE--------KKKKSNSS----PSLWY 289
                                              |.:.||        ||||...|    |..|.
Zfish   265 KKARNNLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYPQSWL 329

  Fly   290 --CYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLS 352
              ..:|:...:.....:.||..||.:...|..::.::                            
Zfish   330 VTTIVKSFKGVLLESALFKLLQDLLSFASPQLLKLMI---------------------------- 366

  Fly   353 TSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIR 417
                       .|..|.|     |..|:     |:..|.:::|.|..|..:.|.......:.|::
Zfish   367 -----------AFTQNKD-----SYAWT-----GYLYAVLLVLVAFVQSVVLQQYFQRCFILGMK 410

  Fly   418 IKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHD 482
            ::|::...:|:|:|::       |:||  :.:||:                              
Zfish   411 VRTAIMAAVYKKALVV-------SNDS--RKESTA------------------------------ 436

  Fly   483 IGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFI 547
             |.|.|.|:.|.:...:....||..|:.|.:||:.|..|::.||.| |:..:..:|:|.|:..::
Zfish   437 -GEIVNLMSADAQRFNDVTNFIHLLWSCPLQIALSIAFLWIELGPS-VLSGLLVMVLMVPINGWL 499

  Fly   548 GNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTL 612
            .....:.......:.|.|:|.::|.|.|||::|..||:..|..::||.|.||||.:.|.|...::
Zfish   500 ATKSRQFQMQNMKFKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSV 564

  Fly   613 MAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARV 677
            ...:...|..|::..|..|:|.:..|...|  |.:.|:|::||..|..||.:.|..:.|::...|
Zfish   565 STFIFSCAPALVSLATFAVFVSVSPDNILD--AEKAFTSISLFNILRFPLAMLPQLISIMVQTSV 627

  Fly   678 STRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQK 742
            |.:|||:||                                                        
Zfish   628 SKKRLEKFL-------------------------------------------------------- 636

  Fly   743 SQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMER 807
                               |.:|:..:||.   |:                              
Zfish   637 -------------------SGDDLDTTTVT---HD------------------------------ 649

  Fly   808 PVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIV 872
                |.|.|                   |||:.:|.:.|:..:: ||  |....:.:..|:|..|
Zfish   650 ----SSITA-------------------AVSMTNGTYAWERDTE-PV--LKRVSLDIKPGRLVAV 688

  Fly   873 VGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDF 937
            ||..|||||||:||||.|:..:.||:  :...:::||.||.|:.|.|:::|||||.|...:||..
Zfish   689 VGAVGSGKTSLVSALLGELHSIKGNI--NINGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQS 751

  Fly   938 VLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGE 1002
            |::||||.||::|:|..|.:.|||:|||:||||:||:::|||:||||:|.::||||:::|:.||:
Zfish   752 VIKACALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGK 816

  Fly  1003 HIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAI 1067
            |:|:..|.......::|.||:|..:..:...:.::.:..|.|...|||..:              
Zfish   817 HLFEKVIGPNGLLRDKTRILITHGISFLPYVDEIVVLVHGVVSEIGSYESL-------------- 867

  Fly  1068 IAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANM 1132
                                                                             
Zfish   868 ----------------------------------------------------------------- 867

  Fly  1133 QSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHT 1197
                              .||.|.|           |..|         |..|.|          
Zfish   868 ------------------RASKGAF-----------SEFL---------ETYGKD---------- 884

  Fly  1198 LGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPR 1262
                                                            ||:.|....|.||..|.
Zfish   885 ------------------------------------------------ESNKDNDKKAAAAQTPV 901

  Fly  1263 VQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRM 1327
            .:..:     |..:.|...|...|. ::.:..:|:....|.|...|:       |....:..:..
Zfish   902 YEEIE-----TLPEGLETQADGSPE-DIVSSTLKRENSLRHSQRHSK-------RNGSVKVRKNS 953

  Fly  1328 SMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKET 1392
            |:|....|:                                         ::|.::.:..:..||
Zfish   954 SLRAQKDPE-----------------------------------------DKKGQRLIEKEMMET 977

  Fly  1393 TINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKIS 1457
                                                                         |::.
Zfish   978 -------------------------------------------------------------GRVK 981

  Fly  1458 DDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVT 1522
            ..:||.|:.|.|...:...|:...|.....:..::||..|:                   |..:.
Zfish   982 FSVYLQYLSAMGWWYVGFSFVFYFIQNVAVIGQNLWLSDWT-------------------DDSIE 1027

  Fly  1523 YYFRMY------------AAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQV 1575
            |:.:.|            .|:......:....|........:|.|.||..||..||...:.||..
Zfish  1028 YFNQTYPNHIRDTRIGVFGALGLAQGFLVFFGTILLADGSISASRTLHTSLLTNILKVPMMFFDT 1092

  Fly  1576 TPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTI----TPWILVLTLPICGAYY 1636
            ||.|||||||:.|:..:|:.|..:    .:..:|||..:|..:.:    ||....:.:|:...||
Zfish  1093 TPSGRIVNRFAKDIFTVDEMIPMS----FRSWILCLLGVLGTLFVICLATPIFTAVVVPMAVVYY 1153

  Fly  1637 LIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALL 1701
            .:|:||..::|:|:|:::.:.||:.||..||:.|::.|||:..|.||    .||.| :||...|.
Zfish  1154 FVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRF----LKRNE-HTIDQNLK 1213

  Fly  1702 N-----TSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTK 1761
            :     .|:|||.:.|:.||..:||.|.:                               :||..
Zfish  1214 SVYPWIVSNRWLAMRLESLGNLVVFFAAL-------------------------------FAVIS 1247

  Fly  1762 SPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADA 1826
            ..|   .:..||||:|:|.|.|...|||:|::.:::|....:|||:..||:.|:           
Zfish  1248 RDS---LNSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREYAEIQN----------- 1298

  Fly  1827 DVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYR 1891
                                                                             
Zfish  1299 ----------------------------------------------------------------- 1298

  Fly  1892 QGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKV 1956
                                                    :|...|||     .||  ||     
Zfish  1299 ----------------------------------------EAPWVTSV-----RPP--DD----- 1311

  Fly  1957 VLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSG 2021
                               ||..|:|.|::..:||..:.:.|:..:|..|.:.::|||.||||:|
Zfish  1312 -------------------WPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKIGIVGRTGAG 1357

  Fly  2022 KSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDL 2086
            ||||...||.:::...|.|.|||:||..:...:||:||:|||||..||:.|:|.||||...|.|.
Zfish  1358 KSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDA 1422

  Fly  2087 QLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLD 2151
            ::|:.||||.|||:|.| ||.||:..:.:||.|||.|.|||||||||:||.|..|:|||||:.:|
Zfish  1423 EIWSVLELAHLKEYVRG-LPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILILDEATAAVD 1486

  Fly  2152 SSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEG 2209
            ..|:..:.......|...|::||||||.||||..|::|||.|:|||..:|.||....|
Zfish  1487 LETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSRVMVLDSGKIVEFDSPNELLSKPG 1544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SurNP_001334732.1 None
abcc2NP_956883.2 MRP_assoc_pro 10..1555 CDD:188098 508/2268 (22%)
ABC_membrane 346..612 CDD:294371 80/357 (22%)
ABCC_MRP_domain1 656..856 CDD:213217 85/204 (42%)
ABC_membrane 1001..1270 CDD:279056 87/330 (26%)
ABCC_MRP_domain2 1316..1536 CDD:213211 108/220 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.110

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