Protein Alignment Sur and CG10505

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Alignment Length: 2015
• Identity: 437/2015 - (21%)
• Similarity: 690/2015 - (34%)
• Gaps: 783/2015 - (38%)

  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLE----LEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSPS 286
            |...||..|.|:..:...|.:|.|:    .|.|.....|...|:...|:   ..|.|||   :||
  Fly    19 ANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHW---EKESKKK---NPS 77

  Fly   287 LWYCYIK-NSWQ---MFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVA 347
            |.....| ..||   :..|..:|::|...|.   ||.:..::.|.  .|.|
  Fly    78 LMRLIFKVYGWQFVPVCILYSLLEMAIHSFQ---PLLLGGLISYF--AYGQ-------------- 123

  Fly   348 NVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILN 412
                               |.:.|...|      |.|.|     |||.:.:|.........::.
  Fly   124 -------------------TTVTKESAY------LYAMG-----IVLCSLVTSLVFHPFMFYVF- 157

  Fly   413 MTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEP 477
            ..|.|::.:..||:|||.|..:|..|   ....||..|..|.
  Fly   158 AVGTRVRLACAGLVYRKCLRASASSG---EGLGGQAISVMSI----------------------- 196

  Fly   478 NISHDIGSITNHMTEDTRNIMEF---FLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVI 539
                              ::.:|   |...|..|..|.:..:..||:...:|.:::|| ||.|||
  Fly   197 ------------------DLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIG-IAFIVI 242

  Fly   540 MTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLN 604
            :.|||.:...|.:......|.:.|.|:|.:::.:..|:|||:.||::.|.:.|...|:.|:|.:.
  Fly   243 LIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIR 307

  Fly   605 KDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDL-NASRLFSSLALFQQLTVPLL-IFPI 667
            ...:.:..:. .|::.:.:..|::|..||::.     || .|.::|...:.:..|...|| .:|:
  Fly   308 GSMSIYAALQ-CTNMISKISLFLSLVAYVYVG-----DLVTAKKVFILSSYYGLLNDSLLHYWPM 366

  Fly   668 TVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAEN 732
            .:.......||.||:..||
  Fly   367 AITTWAQTLVSARRVVEFL---------------------------------------------- 385

  Fly   733 RLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRP 797
                  |..:..|.|......|.|   |..||...|:   :.|....||...:.|
  Fly   386 ------LQVEKPTEESCCRDNPGL---ELDAEKPKPA---QSGRLHCVQSETKCL---------- 428

  Fly   798 PKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGI 862
                        .|..:.|    ||.:.|:                    .|.:.|    |:.||
  Fly   429 ------------SFRKVSA----SWDKPSI--------------------KQPRKP----HIEGI 453

  Fly   863 I--VPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENIL 925
            .  :..|:...:||..||||::||.|:|.|:.|:.|.:..|.  .|||.:||||:...:||||||
  Fly   454 SFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHG--RISYAAQQPWVFQGSIRENIL 516

  Fly   926 FGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMD 990
            |.|.:..|||..|:.||.|..|:||:||||.:::|||||::||||:.|||:|||:|..|::.:.|
  Fly   517 FVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFD 581

  Fly   991 DPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIEL 1055
            ||||::|.:||:.:...|...:|....|  ||||..:..:|..:.|:.::.|::...|||.:
  Fly   582 DPLAAVDAQVGKLLMDKCFHRLLDGKMR--ILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEE--- 641

  Fly  1056 MQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADA 1120
                                                  ||:|
  Fly   642 --------------------------------------LKDV----------------------- 645

  Fly  1121 IDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQG 1185
                                                                             
  Fly   646 ----------------------------------------------------------------- 645

  Fly  1186 DDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVD 1250
                                                                             
  Fly   646 ----------------------------------------------------------------- 645

  Fly  1251 GGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDH 1315
                                 :|||..|...|
  Fly   646 ---------------------ITHHAALDLEA--------------------------------- 656

  Fly  1316 VRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEK 1380
            :....||..|.:|.            :..|:..||..||..     ||:|...:||
  Fly   657 IEADKQQVKRVLSQ------------VDRTSKQLSKGEEKD-----PATIQDENGN--------- 695

  Fly  1381 PKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARL 1445
                                                |:|:..
  Fly   696 ------------------------------------AEQQLQ----------------------- 701

  Fly  1446 AIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQ--CLRVYTDIWLQQWSNVHGRVASKG 1508
                    |.:|.|.|..|.||.|.|.:....::..:..  |..| .||::.:|:...   ..:|
  Fly   702 --------GAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAV-MDIFISRWATWE---EDRG 754

  Fly  1509 HVVLHPSEQDHEVTYYFRM--YAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLH 1571
                :.|..|:|.|....:  |..:..:.:.:.|:.|....:........|||:|...|:...::
  Fly   755 ----YDSVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMY 815

  Fly  1572 FFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPW-------ILVLTL 1629
            ||...|.||::||||:|:..:|..:.......||| |:.:.|:|:.|.|..:       |:|:.|
  Fly   816 FFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQF-LVDVVAVLVIVAIANYWLLIPAAIMVILL 879

  Fly  1630 PICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEAN 1694
            ..|.|.|:      .::|.|:|||:.|.||:.||.::|..|.:|||:.:...:..:........|
  Fly   880 YFCRALYI------GASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTN 938

  Fly  1695 TIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAV 1759
            :.|..|..:::|......|.:  |::::..||                           |....:
  Fly   939 SSALFLYVSANRAFSFWTDLI--CVIYILAVT---------------------------FSFLVI 974

  Fly  1760 TKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADA 1824
            .:|...     ..|||||..::.:.|...|.::..|:||....||||:..|||
  Fly   975 NQSFYS-----GDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQ------------ 1022

  Fly  1825 DADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCG 1889
                                                                             
  Fly  1023 ----------------------------------------------------------------- 1022

  Fly  1890 YRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDK 1954
                                                                             
  Fly  1023 ----------------------------------------------------------------- 1022

  Fly  1955 KVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTG 2019
               .|:||..:..:..::...|||.|.:.|.::.:||....::::..|..:....::|||.||||
  Fly  1023 ---TPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTG 1084

  Fly  2020 SGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQ 2084
            :||||:..:||. |....|.|.||.:||.::...:||:|:||||||..||:.|:|.||||.....
  Fly  1085 AGKSSIIQALFR-LALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKS 1148

  Fly  2085 DLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSV 2149
            |..||:.|:..:||:.| ..|..||...:.|||.|.|.|.|||:||||||||.:..||:||||:.
  Fly  1149 DESLWSALDDVKLKKHV-ASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATAN 1212

  Fly  2150 LDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRE-LQQLEGSVFR 2213
            :|:.|:..:.:.....|...|::||||||.|::|.|.::|:|.|:|||.|.|.: ||:.:|::.:
  Fly  1213 VDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLK 1277

  Fly  2214  2213
              Fly  1278  1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	434/2004 (22%)
		ABC_membrane	95..360	CDD:294371	77/365 (21%)
		ABCC_MRP_domain1	428..632	CDD:213217	89/257 (35%)
		ABC_membrane	728..994	CDD:294371	73/314 (23%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	95/220 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.160