DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and abcc4

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001007039.2	Gene:	abcc4 / 368620	ZFINID:	ZDB-GENE-030616-511	Length:	1331	Species:	Danio rerio

Alignment Length:	2033	Identity:	470/2033 - (23%)
Similarity:	741/2033 - (36%)	Gaps:	805/2033 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQM-------KLEDSARSHYDHFLYIYTEKKKKSNS 283
            |..:|:..|.||.||..:|.|..||.:|:..:       ||.:..:|::|.    ..||..|...
Zfish    20 ANLFSQIFFCWLNPLFSIGSKRRLEEDDMFNVLPEDRSKKLGEELQSYWDQ----EKEKAAKELK 80

  Fly   284 SPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVAN 348
            :|.|....|:..|:.:|:.|:..|..:...:|.|:.:.|:::|.|. |..          :::|
Zfish    81 TPKLTKAIIRCYWKSYAVLGVFTLIEESIKVIQPVFLGKLIKYFEN-YRH----------DDMA- 133

  Fly   349 VLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNM 413
                       ...|.:|                .|.|.|::.:.|      ..|.....:.:..
Zfish   134 -----------ALSEAYG----------------YATGVCLSTLGL------ALLHHLYFYHVQR 165

  Fly   414 TGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPN 478
            .|::|:.::..:||||:|.|:|         |...|:|:
Zfish   166 AGMKIRIAMCHMIYRKALCLSA---------AAMGQTTT-------------------------- 195

  Fly   479 ISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPL 543
                 |.|.|.::.|.....|..:.:|:.|..|.:.|.||.||:..:|.|.:.| :|.:|.:.||
Zfish   196 -----GQIVNLLSNDVNKFDELTIFLHFLWVGPLQAAAVIGLLWQEIGPSCLAG-MAVLVFLMPL 254

  Fly   544 QFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKE--------- 599
            |...|...||.....|..||.|::.:::.:.||::||:.||::.|...:.:.||||
Zfish   255 QTMFGKLFSKYRSKTAALTDSRIRTMNEVVSGIRIIKMYAWEKPFAMLVNDVRRKEISKIMSSSY 319

  Fly   600 LKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQ--QLTVPL 662
            |:.||. |:|:|        |..:|.|||..|||.:..    .::|||:|.:::|:.  :||| .
Zfish   320 LRGLNM-ASFFT--------ANKIILFVTFTVYVLVGN----TMSASRVFVAVSLYSAVRLTV-T 370

  Fly   663 LIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRT 727
            |.||..:..:..:.:|.||:::||                        .||
Zfish   371 LFFPAAIEKVSESAISIRRIKKFL------------------------LLD-------------- 397

  Fly   728 AQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPY 792
                               ||..|..||.|  ||..|   ||
Zfish   398 -------------------ELVKNHLPLSQ--EEKKE---PS----------------------- 415

  Fly   793 VAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQL 857
                                                        |.:.|.:..|......|.:|
Zfish   416 --------------------------------------------VEMQDLICYWDKTLDAPTLQ- 435

  Fly   858 HVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRE 922
            :|...:.| |:|..|:|..|:||:||||.:|.|:|...|.:  .....::|.|||||:...|||.
Zfish   436 NVCFTVKP-GQLLAVIGPVGAGKSSLLSTVLGELPAEKGVI--KVKGELTYASQQPWVFPGTIRS 497

  Fly   923 NILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVV 987
            |||||:..:|:||:.||.|||||.|:||:|.|||::||:||..:||||:.|:.:|||:|..|::.
Zfish   498 NILFGKELQPQRYERVLRACALKRDMELLPDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIY 562

  Fly   988 IMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYAD 1052
            ::||||:::|.||..|:|:.|:..:|:...|  ||||.||..:|.|..::.:|:|.:.|.|||::
Zfish   563 LLDDPLSAVDAEVSRHLFEQCVCGILKDKPR--ILVTHQLQYLKAANQILVLKEGHMVARGSYSE 625

  Fly  1053 IELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACH 1117
            ::                                                |..:..|
Zfish   626 LQ------------------------------------------------QSGLDFT-------- 634

  Fly  1118 ADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDE 1182
                             :::::|::
Zfish   635 -----------------SLLKKDEE---------------------------------------- 642

  Fly  1183 CQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAES 1247
                                                   .||.|..|:.
Zfish   643 ---------------------------------------EESGSEKGEA---------------- 652

  Fly  1248 SVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPL 1312
                         ||                     ||                 ||.|.|::.:
Zfish   653 -------------PR---------------------SP-----------------RSRTVSQNSV 666

  Fly  1313 DDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQS 1377
            ..|                             ::|:||:.::|
Zfish   667 RSH-----------------------------SSSVLSVKDDS---------------------- 680

  Fly  1378 EEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPL 1442
                                                    ||......|.:||..
Zfish   681 ----------------------------------------DQLPAEPVHTMAEEL---------- 695

  Fly  1443 ARLAIDTERKYGKISDDIYLMYIRA-AGLPIITIFFITALIWQCLRVYTDIWLQQW--------- 1497
                    |..|.|...:|..|.|| |.:.::.:..:..|:.|...:..|.||..|
Zfish   696 --------RSEGNIGIRMYWKYFRAGANVVMLVLLLLLNLLAQTFYILQDWWLSYWATEQEKLDH 752

  Fly  1498 --SNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAIS----------CVCIIMALVSTPAGQYAG 1550
              :|.:....|.|:     :.|..::.:|..:||.::          |:.:..||||
Zfish   753 NTNNTNTNNTSAGN-----TTQQLDLNFYLGIYAGLTGATIVFGFMRCLIMFNALVS-------- 804

  Fly  1551 CNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAIL 1615
              :...||:::..:||...:.||.:.|:|||:||||.|:..:|..:..|....:|..|..:..|.
Zfish   805 --SAEMLHNRMFNSILRTPVRFFDINPIGRILNRFSKDIGHLDSLLPWTFVDFIQVFLQIVGVIA 867

  Fly  1616 INVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQ 1680
            :..::.||||:..||:...:..:::::..::|:::|||:.|.|||.||||.::||:.|||||..:
Zfish   868 VASSVIPWILIPVLPLLICFLFLRRYFLRTSRDVKRIESTTRSPVFSHLSSSLQGLWTIRAFKAE 932

  Fly  1681 TRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSP 1745
            .||.:......:.::.|:.|..|:.||..|.||  |.|.||| |:||.     .|....:...:.
Zfish   933 ERFQQTFDAHQDLHSEAWFLFLTTSRWFAVRLD--GMCSVFV-TITAF-----GCLLLKDTMNAG 989

  Fly  1746 SASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHY 1810
            .                          ||||::|.:.:.....|.|:..|::|....||||:..|
Zfish   990 D--------------------------VGLALSYAVTLMGMFQWGVRQSAEVENMMTSVERVVEY 1028

  Fly  1811 AQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQ 1875
            .:                                     .:|:|     |..|           |
Zfish  1029 TE-------------------------------------LESEA-----PWET-----------Q 1040

  Fly  1876 QRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVI 1940
            :|
Zfish  1041 KR--------------------------------------------------------------- 1042

  Fly  1941 KDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLK 2005
                  |..|                         ||.||.|.||.|:..|......|:.|::..
Zfish  1043 ------PSPD-------------------------WPNRGLITFDRVNFSYSSDGPVVLKNISAM 1076

  Fly  2006 IPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFN 2070
            ....:::||.||||:|||||..:||. |....|.|.:|.|....|...:||.::||||||..||.
Zfish  1077 FRPREKVGIVGRTGAGKSSLISALFR-LSEPEGKILVDGVLTSEIGLHDLRQKMSIIPQDPVLFT 1140

  Fly  2071 ATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAIL 2135
            .|:|:||||.....|..||..||..|||..|. .||..|:|.:.:.|.|.|.|.|||:|||||||
Zfish  1141 GTMRKNLDPFNQHSDHDLWKALEEVQLKAAVE-ELPGKLETELAESGSNFSVGQRQLVCLARAIL 1204

  Fly  2136 RGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGN 2200
            |.:..|::||||:.:|..|:..:.|.....|:..|::||||||.||:|.||::|||.|||.|...
Zfish  1205 RKNRVLIIDEATANVDPRTDELIQKTIRDKFKECTVLTIAHRLNTIIDSDRILVLDAGRIHEYDA 1269

  Fly  2201 PRELQQLEGSVFRGLLEK 2218
            |..|.|.:..:|..::::
Zfish  1270 PHVLLQNQSGIFYKMVQQ 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
abcc4	NP_001007039.2	SunT	11..1289	CDD:331423	470/2033 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010