Protein Alignment Sur and CG9270

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_995741.2
• Gene: CG9270 / 35366
• FlyBaseID: FBgn0032908
• Length: 1292
• Species: Drosophila melanogaster
• Alignment Length: 2027
• Identity: 452/2027 - (22%)
• Similarity: 719/2027 - (35%)
• Gaps: 795/2027 - (39%)

  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSS----PS 286
            |..:|...|.:..|:|:.|.|:.||..||.....|..|.:..|.|...:..:.:....|    ||
  Fly    14 AGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDSPKKEPS 78

  Fly   287 LWYCYIK-NSWQMFALG---GILKLA--GDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNE 345
            :....:| ..||:|..|   |:|:|.  ..|..::|.|    |.|:...             ||
  Fly    79 IIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGAL----IAEFTRN-------------GN- 125

  Fly   346 VANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHI 410
                                |..:         |:.:.  |..:...:|.:.:....|.....|:
  Fly   126 --------------------GDGL---------WAQIY--GLTLILSILFSVLMFHPLMMGLMHL 159

  Fly   411 LNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPS 475
                .::::.::...||||:|.|:.....|:  :.|||.:.
  Fly   160 ----AMKMRVAVSTAIYRKALRLSRTALGDT--TTGQVVNL------------------------ 194

  Fly   476 EPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIM 540
               ||:|:|..       .|.::.|    |:.|..|.::.:..|.||..:|::::.| |..:::.
  Fly   195 ---ISNDLGRF-------DRALIHF----HFLWLGPLELLISSYFLYQQIGVASLYG-IVILLLF 244

  Fly   541 TPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNK 605
            .|:|.|:....|:.....|..||:|::.:::.:.||:|||:..|::.|.:.|:..||.|:..:.|
  Fly   245 LPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRK 309

  Fly   606 ----DATFWTLMAVLTHIA--TVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQL--TVPL 662
                ..|..:....|:.||  ..|:.||.:|          .:|.|.|.||..|.:..|  || .
  Fly   310 VNYIRGTLLSFEITLSRIAIFVSLLGFVLMG----------GELTAERAFSVTAFYNILRRTV-C 363

  Fly   663 LIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRT 727
            ..||..:.......|:.||::.|:..||
  Fly   364 KFFPSGMSQFAEMMVTLRRIKGFMMRSE------------------------------------- 391

  Fly   728 AQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPY 792
                   .|....:..||                               |||.:.
  Fly   392 -------TEALYLKGGQT-------------------------------NKLFEG---------- 408

  Fly   793 VAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQL 857
                         |..|:....:||    |..|.:     :.:..:||              :.|
  Fly   409 -------------EPLVKLQSFQAR----WNHDHV-----EPVLENIN--------------ISL 437

  Fly   858 HVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRE 922
            ..|       :|..|:|..||||:||:.|:|.|:|..:|.:  .....|||.||:|||.|.::|:
  Fly   438 SPP-------QLVAVIGPVGSGKSSLIQAILGELPGESGKL--KVQGDISYASQEPWLFNASVRD 493

  Fly   923 NILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVV 987
            |||||......||..|:..|||:.|.||: .||.:.:||||.::|||||.||::|||:|..|:..
  Fly   494 NILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTY 557

  Fly   988 IMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYAD 1052
            ::||||:::|..||.|:|:.|:|..|:  ::..||||.||..::.|:.::.:..|::.|.|:|.:
  Fly   558 LLDDPLSAVDTHVGRHLFEECMRGFLR--DKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEE 620

  Fly  1053 IELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACH 1117
                             |.|:     .|:.|:..|.|       ..::|         |:|
  Fly   621 -----------------MLKS-----GQDFGKLLATE-------AQEMG---------DSN---- 643

  Fly  1118 ADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDE 1182
                                  .:||:
  Fly   644 ----------------------QEQVN-------------------------------------- 648

  Fly  1183 CQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAES 1247
            .:||                |||..|::
  Fly   649 AEGD----------------SRNDKSTY------------------------------------- 660

  Fly  1248 SVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPL 1312
                                           ||.:|....:.|.:.|
  Fly   661 -------------------------------SRQSSRVSRVSVTSVD------------------ 676

  Fly  1313 DDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQS 1377
                                          |:|.|||.                      ||.|
  Fly   677 ------------------------------SSTESILD----------------------NERQ- 688

  Fly  1378 EEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPL 1442
                                                  ||.:
  Fly   689 --------------------------------------PAQE----------------------- 692

  Fly  1443 ARLAIDTERKYGKISDDIYLMYIRAAG---LPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRV 1504
                   .|..|||...||..|..|..   :.|:..||  .|..|.|....|.:|..|
  Fly   693 -------SRSQGKIGLGIYGKYFSAGSGWLMVILVAFF--CLGTQILASGGDYFLSYW------- 741

  Fly  1505 ASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKT 1569
                   :..::.......|  :::.|:...:|.||:.|........::...||:.:.|.:....
  Fly   742 -------VKNNDSSSSTDIY--IFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTA 797

  Fly  1570 LHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTIT-PWILVLTLPICG 1633
            |:||...|.|||:|||:.|:..:|:.:.|.....:|. .|.:|.|:..:.|| ||.|:.|:.:..
  Fly   798 LYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQI-FLTISGIIGVLCITNPWYLINTITMFL 861

  Fly  1634 AYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAY 1698
            |::.::.||..::|:|:|:|....||:.||.|.|:.|::||||...|...|:......:.::..|
  Fly   862 AFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGY 926

  Fly  1699 ALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSP 1763
            ....:::|..|..||..  |:.:|.:||.:
  Fly   927 YTFLSTNRAFGYYLDLF--CVAYVISVTLM----------------------------------- 954

  Fly  1764 SELRP---SPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADAD 1825
            |...|   :|..:||.|...:.:...:.|.::..|::|....||||:..|..
  Fly   955 SYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRH------------- 1006

  Fly  1826 ADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGY 1890
                                                       ::.:|:
  Fly  1007 -------------------------------------------LEAEGE---------------- 1012

  Fly  1891 RQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKK 1955
                                        |..|                           |||
  Fly  1013 ----------------------------FESP---------------------------DDK--- 1019

  Fly  1956 VVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRY--EGQKQNVISNLTLKIPAGQRIGICGRT 2018
                 :|          |::|||.|.|..:.:||||  :.:...|:.:|...|...::|||.|||
  Fly  1020 -----KP----------PMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRT 1069

  Fly  2019 GSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYF 2083
            |:|||||..:||. |....|.:.||:.||..|...:||:::|||||:..||:.|:|.||||...:
  Fly  1070 GAGKSSLINALFR-LSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQY 1133

  Fly  2084 QDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATS 2148
            .|.:||..||...||:.|: .||.||::|:.:||.|.|.|.|||:||||||||.:..||:||||:
  Fly  1134 ADEKLWEALEEVHLKDEVS-ELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATA 1197

  Fly  2149 VLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRE-LQQLEGSVF 2212
            .:|..|::.:.......||..|::||||||.||:|.||::|||.|.:||.|:|.| |.|....||
  Fly  1198 NVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVF 1262

  Fly  2213 RGL-LEKGASKW 2223
            .|: |:.|.|.:
  Fly  1263 YGMVLQTGRSSF 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	445/2008 (22%)
		ABC_membrane	92..362	CDD:294371	78/373 (21%)
		ABCC_MRP_domain1	412..611	CDD:213217	84/233 (36%)
		ABC_membrane	718..981	CDD:294371	76/318 (24%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	103/222 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.160