Protein Alignment Sur and MRP

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Alignment Length: 2194
• Identity: 503/2194 - (22%)
• Similarity: 809/2194 - (36%)
• Gaps: 828/2194 - (37%)

  Fly    78 LLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVE 142
            ::...:|.|..||:|      |||.:........:            :|..|||::      .:.
  Fly   115 IIKFATFLLLFIFIP------LNRKYGVQTTGCQF------------IFWFLLTVL------SIP 155

  Fly   143 RKKATVFLYASTAVEALTFALLSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGL---TVY 204
            |.:..|.|.|... :.|.....|.:.|....|: |:.........|.|.::: ...||:   |.|
  Fly   156 RCRTEVRLDAERQ-KILNSQQPSEQDFSWEEYQ-FVSFFIFFTFTSIMLILN-CFADGMPRQTKY 217

  Fly   205 KECYHDDYLDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDS------- 262
            :.          |:.......|:|.|:..:.|...:...||:.|||.:||..::.:||
  Fly   218 QR----------GENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPI 272

  Fly   263 --------ARSHYDH----------------FLYIYTEKKKKSNSSPSLWYCYIKNSWQMFALGG 303
                    .|.:|.:                |...:.||..:.....|:.....|:...:|..|.
  Fly   273 FAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGA 337

  Fly   304 ILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTN 368
            ::||..|......|..:..|:.::|   ||.:||
  Fly   338 LMKLFTDTLTFAQPQVLSLIISFVE---AQDAEP------------------------------- 368

  Fly   369 IDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILN-------MTGIRIKTSLQGLI 426
                                 .|..:|.|:....|:.|.|.||.       :.|:||:|:|...|
  Fly   369 ---------------------EWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAI 412

  Fly   427 YRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMT 491
            |||:|.:                   |.|.:|:..                     :|.|.|.|.
  Fly   413 YRKALRI-------------------SNSTKKEST---------------------VGEIVNLMA 437

  Fly   492 EDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAE 556
            .|.:..||....::..|:.|.:|.:.:|.|:..||.| |:..:|.::|:.|:...|.:.:.....
  Fly   438 VDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPS-VLAGLAVMIILIPVNGVIASRIKTYQI 501

  Fly   557 VIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKEL------KYLNKDATF-WTLMA 614
            ....|.|||:|.:::.|.||||:||.||:..|.|::.:.|.||:      .|||...:| |:
  Fly   502 RQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWS--- 563

  Fly   615 VLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVST 679
                .|..|::.||...||......:  |:..::..|:|||..:.:||.|.|:....|...:||.
  Fly   564 ----CAPFLVSLVTFATYVLTSEANQ--LSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSV 622

  Fly   680 RRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQ 744
            .|:.:||.|
  Fly   623 NRINKFLNS-------------------------------------------------------- 631

  Fly   745 TPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPV 809
                               |::.|::|                            :..|....|
  Fly   632 -------------------EELDPNSV----------------------------LHDSSKPHP- 648

  Fly   810 EFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVG 874
                                       :||.:|.|:|..:     :.|....|.|.||.|..:||
  Fly   649 ---------------------------MSIENGEFSWGDE-----ITLRNINIEVKKGSLVALVG 681

  Fly   875 KNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVL 939
            ..||||:|::.|.|.||..|||.:  :....::||.||.|:.|.|:|:|||||:::..|||:.|:
  Fly   682 TVGSGKSSVVQAFLGEMEKLAGVV--NTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVI 744

  Fly   940 EACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHI 1004
            :||||:.||:::..|||:.|||:|||:||||:|||::|||:||.|::.::||||:::|..||:||
  Fly   745 DACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHI 809

  Fly  1005 FQHCI--REMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAI 1067
            |:..|  :.:|.:.:|  :|||..:..:.:.:.:..||.|.:...|::.
  Fly   810 FEEVIGPKGILARKSR--VLVTHGVTFLPQVDSIYVIKMGEISESGTFD---------------- 856

  Fly  1068 IAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANM 1132
                                    :|:|                 |....||.|       :.::
  Fly   857 ------------------------QLVK-----------------NKGAFADFI-------IQHL 873

  Fly  1133 QSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHT 1197
            |....||::...:...|.:.:                     |||                  ..
  Fly   874 QEGNEEEEELNQIKRQISSTA---------------------DVP------------------EL 899

  Fly  1198 LGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPR 1262
            ||     ....:.:|       |.:||       ||.|:..||    |:|.:.||.
  Fly   900 LG-----TVEKAIKL-------ARTES-------LSDSISVTS----ADSLMGGGG--------- 932

  Fly  1263 VQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRM 1327
                                                                             
  Fly   933 ----------------------------------------------------------------- 932

  Fly  1328 SMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKET 1392
            |:||..|.::.|..:::..|:                               |.|:
  Fly   933 SLRRRTKRQDSHDSVASAASL-------------------------------KKKQ--------- 957

  Fly  1393 TINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTER-KYGKI 1456
                                                 ||.|:           .|:||: :.|.:
  Fly   958 -------------------------------------EVEGK-----------LIETEKSQTGGV 974

  Fly  1457 SDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEV 1521
            ...:|..||::.|:.:.....:...::|..::.:::||.||:|                  |..|
  Fly   975 EFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWAN------------------DQNV 1021

  Fly  1522 T-------YYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTL-HFFQVTPL 1578
            .       .|..:|.|......::|..:.......|..|.:.:|::||..|:..:: .||.:||:
  Fly  1022 ANDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPI 1086

  Fly  1579 GRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYR 1643
            ||::|.||.||.|:|:::.||....:.|..:.|:.|::....||..|.:.:||...||..|:||.
  Fly  1087 GRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYV 1151

  Fly  1644 CSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWL 1708
            .::|:|.|:|:.:.||:.||.|||:.|.:||||:|...||.|....:::.|.:.......::|||
  Fly  1152 ATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWL 1216

  Fly  1709 GVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLV 1773
            .:.|:.:|..|:..|::.|:...                                   :.:|.||
  Fly  1217 AIRLEMVGNLIILFASLFAVLGG-----------------------------------QTNPGLV 1246

  Fly  1774 GLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSS 1838
            ||:::|.|.|...|||:|::.:|:|....|||||..|.:
  Fly  1247 GLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGE-------------------------- 1285

  Fly  1839 NEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANAD 1903
                                                                             
  Fly  1286 ----------------------------------------------------------------- 1285

  Fly  1904 KLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLER 1968
                                                  .||..|.:.::||     |:|.
  Fly  1286 --------------------------------------TKQEAPWELEQDK-----NKPK----- 1302

  Fly  1969 YQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVL 2033
                  :|||.|.:.|.|..:||......|:..::..|..|:::||.||||:|||||.|:||.::
  Fly  1303 ------NWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRII 1361

  Fly  2034 QTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLK 2098
            :...|.|.||.|||..:....||:||:|||||..||:.::|.||||.....|.::|..|||:.||
  Fly  1362 EAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLK 1426

  Fly  2099 EFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAAD 2163
            .||.. |..||:..|.:||.|||.|.|||:|||||:||.:..|||||||:.:|..|:..:.|...
  Fly  1427 SFVKS-LAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIR 1490

  Fly  2164 LAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVF 2212
            ..|:..|::||||||.||||.|::||||:|:|:|..:|.||.....|.|
  Fly  1491 TEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	503/2194 (23%)
		ABC_membrane	338..601	CDD:279056	86/367 (23%)
		ABCC_MRP_domain1	649..848	CDD:213217	88/207 (43%)
		ABC_membrane	988..1260	CDD:279056	83/324 (26%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	104/220 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.160