DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and CG7627

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster

Alignment Length:	2052	Identity:	454/2052 - (22%)
Similarity:	732/2052 - (35%)	Gaps:	803/2052 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 FYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSPSLWYCYI 292
            |.|.:|||:..|....|.|..|:.:||.:...|..:.:..:.....:..:.:|:...|:|
  Fly    19 FISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGKPNL----- 78

  Fly   293 KNSWQMFALGGILKLAGDLFALIG--------------PLAIQKIVEYIEQLYAQASEPPAKSPG 343
                    |..:|::.|..|||:|              |:.:.|::.|    |...||
  Fly    79 --------LRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAY----YTHGSE------- 124

  Fly   344 NEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAA---ITQGALSQ 405
                                    :|:....|:             |.::|.:|   |.......
  Fly   125 ------------------------SIESAYYYA-------------AGVILCSALNVIIMHPYML 152

  Fly   406 ASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEH 470
            .:.|:    |::::..:..:||||:|.|                |.|:..|         .|..|
  Fly   153 GTMHV----GLKMRVGMCSMIYRKALRL----------------SKSALGD---------TTAGH 188

  Fly   471 VDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIA 535
            |.|    .:|:|:|.:      |...|     .:||.|..|.:...:.||:|..:||:||.| :|
  Fly   189 VVN----LMSNDVGRL------DLATI-----FVHYLWVGPLETLFITYLMYREIGIAAVFG-VA 237

  Fly   536 CIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKEL 600
            .:::..|||.::|...|......|..||||::.:::.:.||:|||:.||:..|...:..||:||:
  Fly   238 FMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEI 302

  Fly   601 ------KYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQL- 658
                  .|:......:.:......|...|:.:|.||.:          |.....|...|.:..|
  Fly   303 NAIRHVSYIRGILLSFIIFLTRVSIFLSLVGYVLLGTF----------LTPEVAFLITAYYNILR 357

  Fly   659 TVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNM 723
            |...:.||..:..:....||.:|::::::|.|              .:..|.|:|:.|..:.||
  Fly   358 TTMTVFFPQGISQMAETLVSIKRVQKYMQSDE--------------TNVMDMSVDLTEDFQGSN- 407

  Fly   724 TMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLR 788
             ..|..|:..........|...|.:||    :.:||:.|
  Fly   408 -QETVHADGDEERDEAEDKLLGPPIAT----VNENAKLS-------------------------- 441

  Fly   789 NTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMP 853
                                                         :..:||:..:..|...|  |
  Fly   442 ---------------------------------------------EAGISISGLMAKWDVNS--P 459

  Fly   854 VVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLND 918
            ...|:...:.|..|.:..:||:.||||:||:.|:|.|:|..:|.:  ....::||.||:|||.:.
  Fly   460 DYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEI--KVNGSMSYASQEPWLFSG 522

  Fly   919 TIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSS 983
            |:|:|||||:....:||..|::.|||:.|.||:|..|.:|:||||.::||||:.||::|||:|..
  Fly   523 TVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRE 587

  Fly   984 ANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACG 1048
            .::.::||||:::|..|..|:|:.|:|..|::  |..||.|.||..::.|:.::.:..|||.|.|
  Fly   588 TSIYLLDDPLSAVDTHVARHLFEQCMRGYLRE--RIVILATHQLQFLQHADQIVIMDKGRVSAVG 650

  Fly  1049 SYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDAN 1113
            :|
  Fly   651 TY--------------------------------------------------------------- 652

  Fly  1114 VACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPL 1178

  Fly   653 ----------------------------------------------------------------- 652

  Fly  1179 PIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSS 1243
                                         .|.|.|||
  Fly   653 -----------------------------ESLRESGL---------------------------- 660

  Fly  1244 YAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSS 1308
                     |.|:...:|...                               ::|||..||.:
  Fly   661 ---------DFASMLADPERD-------------------------------EQSEERSRSRS-- 683

  Fly  1309 ESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKN 1373
                     ||:                .|.|                           :|..:|
  Fly   684 ---------GSY----------------THSH---------------------------SDQRRN 696

  Fly  1374 ETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRE 1438
                           |:::.::..|:|  ..|.|         |:|..:.||
  Fly   697 ---------------SEQSLLSMADSC--MDDLE---------AEQANNQER------------- 722

  Fly  1439 SMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFIT---ALIWQCLRVYTDIWLQQWSNV 1500
                        ::.|:|...:|..|.:|.|  ....||:.   .::.|.|....|.:|..|
  Fly   723 ------------QEAGQIGLRLYSKYFKAGG--GFFAFFVMMGFCVLSQGLASLGDYFLSYW--- 770

  Fly  1501 HGRVASKGHVVLHPSEQD----HEV---------------------TYYFRMYAAISCVCIIMAL 1540
               |..||:|.......|    .|:                     ||.|       .|..::.:
  Fly   771 ---VTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIF-------TVITVLTI 825

  Fly  1541 VSTPAGQYAGCN----ARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQ 1601
            :.|.|..:...|    |...||:.:.:.|....::||...|.|||:||||.||..:|:.:.|...
  Fly   826 LVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMM 890

  Fly  1602 RLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSE 1666
            .::|..|.....:::...:.|..|:.|:.:...:|.::.||..::|:::|:|..|.|||.|||:.
  Fly   891 DVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAA 955

  Fly  1667 TIQGVTTIRAFNQQTRFTEILFKRLE--ANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALT 1729
            ::.|::|||||..| |..|..|...:  .::..|..::|| |..|..||..  |::::|.:|
  Fly   956 SLTGLSTIRAFGAQ-RVLEAEFDNYQDMHSSAFYMFISTS-RAFGYWLDCF--CVIYIAIIT--- 1013

  Fly  1730 AASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLL 1794
                     ......|.|:...                     |||||...:.:...:.|.::..
  Fly  1014 ---------LSFFIFPPANGGD---------------------VGLAITQAMGMTGMVQWGMRQS 1048

  Fly  1795 ADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVY 1859
            |::|....:|||:..|.                     |.||
  Fly  1049 AELENTMTAVERVVEYE---------------------DIEP----------------------- 1069

  Fly  1860 PGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPA 1924
                                               |...||.|||
  Fly  1070 -----------------------------------EGALEAPADK-------------------- 1079

  Fly  1925 TAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSL 1989
                                .||:                          |||::|.|.||.:||
  Fly  1080 --------------------KPPK--------------------------SWPEQGKIVFDELSL 1098

  Fly  1990 RY--EGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRP 2052
            ||  :.:.:||:.:|:..|...:::||.||||:|||||..:||. |....|.:.||..|...:..
  Fly  1099 RYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVLIDKRDTSEMGL 1162

  Fly  2053 DELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGG 2117
            .:||:::|||||:..||:.|:|.||||...:.|.:||..||..:|||.| ..||.||.:.|.:||
  Fly  1163 HDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVV-ADLPSGLQSKITEGG 1226

  Fly  2118 LNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTIL 2182
            .|.|.|.|||:||||||||.:..||:||||:.:|..|:..:.......|:..|::||||||.||:
  Fly  1227 TNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIM 1291

  Fly  2183 DYDRLIVLDQGRIVEDGNPRELQQL-EGSVFRGLLEK 2218
            |.|:::|:|.||.||.|.|.||..| :..||.|::::
  Fly  1292 DSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQ 1328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	450/2037 (22%)
		ABC_membrane	107..360	CDD:294371	78/355 (22%)
		ABCC_MRP_domain1	445..645	CDD:213217	79/205 (39%)
		ABC_membrane	815..1014	CDD:294371	62/221 (28%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	102/222 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.160