Protein Alignment Sur and ABCB5

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001157413.1
• Gene: ABCB5 / 340273
• HGNCID: 46
• Length: 1257
• Species: Homo sapiens
• Alignment Length: 1898
• Identity: 341/1898 - (17%)
• Similarity: 597/1898 - (31%)
• Gaps: 806/1898 - (42%)

  Fly   452 SSTSDEKQKNDDSMATPEHVDNPSEPNISHD-IGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIA 515
            |..::|.|:|.....|.|     .:|.:..: :|||.                       .|:.|
Human     4 SERAEEMQENYQRNGTAE-----EQPKLRKEAVGSIE-----------------------IFRFA 40

  Fly   516 VVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIK 580
            ..:.:..|.|||.|.:.:.||:.:| ||.                     |..:.|.|:...:::
Human    41 DGLDITLMILGILASLVNGACLPLM-PLV---------------------LGEMSDNLISGCLVQ 83

  Fly   581 LNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYV------------ 633
            .|..:.....:.||.       ||:|.|..||..|...:|.::..::.:.:::
Human    84 TNTTNYQNCTQSQEK-------LNEDMTLLTLYYVGIGVAALIFGYIQISLWIITAARQTKRIRK 141

  Fly   634 ------------WLHRDQEFDLNA-----------------SRLFSSLALFQ-QLTVPL------ 662
                        |.......:||.                 :.||.:::.|. .|.|.|
Human   142 QFFHSVLAQDIGWFDSCDIGELNTRMTDDIDKISDGIGDKIALLFQNMSTFSIGLAVGLVKGWKL 206

  Fly   663 -LIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEK--SNMT 724
             |:...|.|:|:|:..:..|:...|.|.|:....:.......:|| |..::..:..|||  ...|
Human   207 TLVTLSTSPLIMASAAACSRMVISLTSKELSAYSKAGAVAEEVLS-SIRTVIAFRAQEKELQRYT 270

  Fly   725 MRTAQAENRLNEKRLAQK----------SQTPELA-TNSTPLLQNAEE-----SAEDISPSTVQE 773
            .....|::...::.:|.|          :.|..|| ...|.|:.|.|.     :...:..|.:..
Human   271 QNLKDAKDFGIKRTIASKVSLGAVYFFMNGTYGLAFWYGTSLILNGEPGYTIGTVLAVFFSVIHS 335

  Fly   774 ---LG-----------------HNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARN 818
               :|                 |...|..::..:.|......:|..:.|:|..:.|.|:
Human   336 SYCIGAAVPHFETFAIARGAAFHIFQVIDKKPSIDNFSTAGYKPESIEGTVEFKNVSFN------ 394

  Fly   819 TDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSL 883
                        .|...::.|..||                 .:.:..|:...:||.|||||:::
Human   395 ------------YPSRPSIKILKGL-----------------NLRIKSGETVALVGLNGSGKSTV 430

  Fly   884 LSAL------------LMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFG-------ES 929
            :..|            :.|..:.|.|: .|....|..|||:|.|...||..||.:|       |.
Human   431 VQLLQRLYDPDDGFIMVDENDIRALNV-RHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEM 494

  Fly   930 FRPKR----YDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMD 990
            .|..|    |||::|          .|....:::||:|..:||||:||||||||:..:..::|:|
Human   495 ERAAREANAYDFIME----------FPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILD 549

  Fly   991 DPLASLDNEVGEHIFQHCIREMLQKSN--RTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADI 1053
            :..::||:|     .:..::..|:|::  ||.|:|..:|..|:.|:.::.:|||.:...|::|::
Human   550 EATSALDSE-----SKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAEL 609

  Fly  1054 ELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHA 1118
                                                       ::|.||..|:.::.|
Human   610 -------------------------------------------MAKRGLYYSLVMSQD------- 624

  Fly  1119 DAIDGSGCISVANMQSNVVEEDDQV-SVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDE 1182
                             :.:.|:|: |::|          :.:||.:|            ||:
Human   625 -----------------IKKADEQMESMTY----------STERKTNS------------LPL-- 648

  Fly  1183 CQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAES 1247
                         |::                          .||..|.:.:          ||.
Human   649 -------------HSV--------------------------KSIKSDFIDK----------AEE 664

  Fly  1248 SVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPL 1312
            |..                                    :.|::.|:|.
Human   665 STQ------------------------------------SKEISLPEVS---------------- 677

  Fly  1313 DDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQS 1377
                         .:.:.:.|||:.....|....|:|:.:......:.| |.|:...||.:
Human   678 -------------LLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIF-AKIITMFGNND---- 724

  Fly  1378 EEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPL 1442
                         :||:..|...||
Human   725 -------------KTTLKHDAEIYS---------------------------------------- 736

  Fly  1443 ARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASK 1507
                                           .||.|..:|  |.
Human   737 -------------------------------MIFVILGVI--CF--------------------- 747

  Fly  1508 GHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHF 1572
                         |:|:            :..|....||:......|......:|.
Human   748 -------------VSYF------------MQGLFYGRAGEILTMRLRHLAFKAMLY--------- 778

  Fly  1573 FQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYL 1637
                          .|:|..|:|..:||.         |:.||
Human   779 --------------QDIAWFDEKENSTGG---------LTTIL---------------------- 798

  Fly  1638 IQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLN 1702
                    |.::.:|:.||.|.:         ||.|                           .|
Human   799 --------AIDIAQIQGATGSRI---------GVLT---------------------------QN 819

  Fly  1703 TSHRWLGVSLDYLGG-----CIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVT-- 1760
            .::..|.|.:.::.|     .|:.:|.|.|:|..                      .||.|:|
Human   820 ATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGM----------------------IETAAMTGF 862

  Fly  1761 --KSPSELRPSPSLVGLAI-NYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADA 1822
              |...||:.:..:...|: |...:|.:     .:..|..:||...::
Human   863 ANKDKQELKHAGKIATEALENIRTIVSL-----TREKAFEQMYEEMLQ----------------- 905

  Fly  1823 DADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGD 1887
                     ..|..:|.:   |::..|..:.:...:|
Human   906 ---------TQHRNTSKK---AQIIGSCYAFSHAFIY---------------------------- 930

  Fly  1888 CGYRQGHENGAEANADKLNAGNVTGDGNHLNF---HHPPATAGD---------KVEQATTKTSVI 1940
            ..|..|...||..    :.||.:|.:|..:.|   .:.....|:         |.:........:
Human   931 FAYAAGFRFGAYL----IQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFAL 991

  Fly  1941 KDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLK 2005
            .:|:  |..|.:.::...|:.....|| ::.|...:|.|.|:.              ::..|:|.
Human   992 LEKK--PNIDSRSQEGKKPDTCEGNLE-FREVSFFYPCRPDVF--------------ILRGLSLS 1039

  Fly  2006 IPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFN 2070
            |..|:.:...|.:|.|||:....|..:....:|.:..|.||.:.:....||::::|:||:..|||
Human  1040 IERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFN 1104

  Fly  2071 ATIRENLDPHGYFQDLQLWNCLELAQLKE---------FVNGHLPLGLDTVICDGGLNLSAGHRQ 2126
            .:|.||:   .|..:.::   :.|.::||         |:.| ||...:|.:...|..||.|.:|
Human  1105 CSIAENI---AYGDNSRV---VPLDEIKEAANAANIHSFIEG-LPEKYNTQVGLKGAQLSGGQKQ 1162

  Fly  2127 LLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLD 2191
            .|.:|||:|:....|:||||||.||:.:|..:..|.|.|..|||.:.:.|||:.|.:.|.::||.
Human  1163 RLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLH 1227

  Fly  2192 QGRIVEDGNPREL 2204
            .|:|.|.|..:||
Human  1228 NGKIKEQGTHQEL 1240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
ABCB5	NP_001157413.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		6/24 (25%)
		PTZ00265	8..1251	CDD:240339	340/1894 (18%)
		ABC_membrane	52..333	CDD:279056	57/310 (18%)
		ABC_MTABC3_MDL1_MDL2	386..623	CDD:213216	77/330 (23%)
		ABC_membrane	696..962	CDD:279056	77/588 (13%)
		ABC_MTABC3_MDL1_MDL2	1016..1254	CDD:213216	78/247 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000