DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and wu:fb13g09

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	XP_009289330.1	Gene:	wu:fb13g09 / 336563	ZFINID:	ZDB-GENE-030131-8507	Length:	1393	Species:	Danio rerio

Alignment Length:	2054	Identity:	458/2054 - (22%)
Similarity:	742/2054 - (36%)	Gaps:	776/2054 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 KIGYKH----SMATFYSKSCFWWLTPLLWLGYKEP-LELEDLGQMKLEDSARSHYDHFLYIYTEK 277
            :|.:||    ..|.|:|.....||:||.|..:|:. |::||:..:...:::.::.....:::.|:
Zfish    53 RITHKHQHPVDNAGFFSFMTLQWLSPLAWRAHKDSCLKMEDVWGLSCHEASETNCQRLEWLWHEE 117

  Fly   278 -KKKSNSSPSL----W-YCYIKNSWQMFALGGILKLAGDLFALIGP-LAIQKIVEYIEQLYAQAS 335
             |::.....||    | :|..:....:|:| .|..:||    .:|| |.|:.::|     ::|.|
Zfish   118 LKRRGKDGASLSRVFWRFCQTRMLVAIFSL-LITMVAG----FVGPALLIRALLE-----FSQCS 172

  Fly   336 EPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQ 400
            |          ..:|...:.:.|....|:           :.:||  ||..|.|.:
Zfish   173 E----------VKLLYGLALVAGIFLMEL-----------TRSWS--LAFMWAINY--------- 205

  Fly   401 GALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSM 465
                        .|..|::.:.....::|.|               :::||...|.
Zfish   206 ------------RTAARLRGAALTFAFQKIL---------------RLRSTKDVSS--------- 234

  Fly   466 ATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIA--------VVIYLLY 522
                              |.:.|....|.:.:.|       |.::...:|        .:.|..|
Zfish   235 ------------------GELVNICASDGQRLYE-------AVSVGCLLAGGPLVGMLGLTYTTY 274

  Fly   523 MNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEV 587
            . ||.:|::|| |..:|..|.........:...:.....||.|::.:::.|..:|.||:..|:..
Zfish   275 F-LGPTALVGS-AIFIIFYPTMMLASRMTAYFRKKCVAVTDRRVRLMNEILGCMKFIKMYCWETP 337

  Fly   588 FLKKIQEARRKELKYLNKDATFWT--LMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFS 650
            |...||:.|.:|.:.|.     |.  :.::...:|.|::...::..:. ||....:||.|::.|:
Zfish   338 FANNIQKVRSEERRNLE-----WAGCVQSLTLGVAPVVVVIASVCTFT-LHMALGYDLTAAQAFT 396

  Fly   651 SLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMY 715
            .:|:|..:|..|.:.|:.|..:....|:.:|.::.....:.:.......:...::...||:|...
Zfish   397 VVAVFNSMTFALKVTPLAVRALSEGSVAVKRFQKLFMMEDRELISVKTEDPYNVVEFKDATLAWE 461

  Fly   716 ET----QEKSNMTMRTAQAENRLNEKRLA-------QKSQTPELATNSTPLLQNAEESAEDISPS 769
            :|    .:||...::....:..|..::|:       .|.:..|  .|:..||.:.|:.:...:.|
Zfish   462 KTCGSQTKKSRTQLKRGGMKRVLRREKLSLYIITEENKGKIEE--PNAEHLLTHMEQESPQSTIS 524

  Fly   770 TVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDD 834
            :.|                     :||||..:
Zfish   525 STQ---------------------SIRPPLHK--------------------------------- 535

  Fly   835 IAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMF 899
                                 .||...:.:.||.|..|.|..||||:|||||||.:|.||.|::
Zfish   536 ---------------------TLHRIDLCIQKGSLVGVCGGVGSGKSSLLSALLGQMTLLGGSV- 578

  Fly   900 WHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGI 964
             ......:||:||.|:|||::|||||||:.:..::|:.|||||.|.|||..:|.||::.|||||.
Zfish   579 -SVNGGFAYVAQQAWILNDSLRENILFGKKYNEEKYNAVLEACCLFPDIIELPYGDMTEIGERGA 642

  Fly   965 NISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHR 1029
            |:|||||||:::|||:||...::::||||:::|..||..:|...||...:  .:|.|.||.||..
Zfish   643 NLSGGQRQRVSLARALYSERPILLLDDPLSAVDARVGSRLFHSAIRPAAK--GKTVIFVTHQLQY 705

  Fly  1030 IKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLL 1094
            :.|.:.::.:|||::...|::.  :||:                             .|..:..|
Zfish   706 LPECDDVVLMKDGQIAEHGTHT--QLME-----------------------------KGRDYAAL 739

  Fly  1095 KNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNL 1159
            .|                               ||  .|.|:|.:                  ||
Zfish   740 FN-------------------------------SV--QQENLVRK------------------NL 753

  Fly  1160 QRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSES 1224
            :.|..
Zfish   754 KNKEK------------------------------------------------------------ 758

  Fly  1225 SSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAME 1289
                                                                  :...|||..:.
Zfish   759 ------------------------------------------------------AEKESSPQTLH 769

  Fly  1290 VANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEE 1354
            |:||
Zfish   770 VSNP------------------------------------------------------------- 773

  Fly  1355 SPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQ 1419
                                      ||.  :.:||:|                         ||
Zfish   774 --------------------------PKP--DTESKKT-------------------------DQ 785

  Fly  1420 EQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLP---IITI---FFI 1478
            ....|                         |:..|.::..:|..||:|||.|   |:||   .|.
Zfish   786 LMQAE-------------------------EKGSGAVAWPVYAAYIKAAGGPLAFIVTILLFLFT 825

  Fly  1479 TALIWQCLRVYTDIWLQQWSN---------VHGRVASKGHVVLHPSEQDHEVTYYFRMY----AA 1530
            |..|     .:::.||..|..         :....|....:.|:|     .:.||.|:|    .|
Zfish   826 TGSI-----AFSNWWLSYWIRQGSGNSSLLLGNETAESDSMRLNP-----HIQYYSRVYVLSMGA 880

  Fly  1531 ISCVCIIMALVSTPAGQYAGCNARRN--LHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVID 1593
            ...:..|..||      :..|..|..  |||||.:|:|...:.||..||||||:||||.||..:|
Zfish   881 ALFLKTIRGLV------FVKCTVRAASVLHDKLFKTLLLSPMRFFDTTPLGRILNRFSKDMDEVD 939

  Fly  1594 KKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNS 1658
            .::|...:.|||...|.|..:.:...:.||.|...:|:....:::.:..|...|||:|:||.:.|
Zfish   940 VRLAMQAEMLLQNVTLVLFCLGVVGAVFPWFLFSIIPLGAFLFIVNRISRVLIRELKRLENISQS 1004

  Fly  1659 PVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVA 1723
            |..||::.::||::||.|:.:...|.......|:.|.....|.:.:.|||.|.||     ::.::
Zfish  1005 PFTSHITSSLQGLSTIYAYGRGADFIHRYQALLDTNQACQFLFSCAMRWLAVRLD-----LISIS 1064

  Fly  1724 TVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLN 1788
            .:|.:....|....|.                             ||:..|||::|.:.:.....
Zfish  1065 LITTVALLIVLMHGHI-----------------------------SPAYAGLALSYAVQLTGLFQ 1100

  Fly  1789 WVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSD 1853
            :.|:||::.|....|||||.||.:
Zfish  1101 FTVRLLSETEARFTSVERINHYIK----------------------------------------- 1124

  Fly  1854 AGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLN 1918
                          :::.:|.:|                                 :||
Zfish  1125 --------------NLESEGPRQ---------------------------------ITG------ 1136

  Fly  1919 FHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIH 1983
                          ..|.:|                                    |||..|.|.
Zfish  1137 --------------CPTSSS------------------------------------SWPAEGQIT 1151

  Fly  1984 FDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQ 2048
            |.:|.:||......|:.||...|...:.|||.|||||||||||::||.:.:.:||.|.||.|:|.
Zfish  1152 FQDVEMRYRDGLPLVLKNLCFSILPEETIGIVGRTGSGKSSLGVALFRLAELSRGSIIIDGVNIA 1216

  Fly  2049 RIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVI 2113
            .|..::||::||:|||:..||..|:|.||||...:.|.|:|..||...:|:.|: .||..|.:.:
Zfish  1217 HIGLEDLRSKLSVIPQEPVLFIGTVRSNLDPWDQYTDAQIWEALEKTHIKDMVS-QLPNSLHSEV 1280

  Fly  2114 CDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRL 2178
            .|.|.|.|.|.|||||:|||:||.|..|:|||||:.:|:.|:..:......:|.|.|.:.|||||
Zfish  1281 TDNGENFSVGERQLLCVARALLRHSKILLLDEATAAIDTETDRLIQDTIRSSFSGCTTLVIAHRL 1345

  Fly  2179 TTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLE 2217
            .|:|..:|::|||||:|:|...|..|...|.|.|..::|
Zfish  1346 NTVLGCNRIMVLDQGQILEFDTPSNLLTDENSRFHAMME 1384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
wu:fb13g09	XP_009289330.1	SunT	61..1386	CDD:331423	455/2046 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10356
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010