DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and abcc5

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001182542.1	Gene:	abcc5 / 336147	ZFINID:	ZDB-GENE-050517-17	Length:	1426	Species:	Danio rerio

Alignment Length:	2050	Identity:	458/2050 - (22%)
Similarity:	736/2050 - (35%)	Gaps:	750/2050 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 DDYGKIGYKHSM------------------ATFYSKSCFWWLTPLLWLGYKE-PLELEDLGQMKL 259
            |..|:..|.||:                  |..:|...|.|||.|..|.:|: .|.|||:..:..
Zfish    69 DAAGRSKYHHSVCVLKPIRSTSKYQHPVDNAGLFSFMTFNWLTSLAVLAHKKGQLFLEDIWAVSQ 133

  Fly   260 EDSARSHYDHFLYIYTEKKKKSNSSPSL----W-YCYIKNSWQMFALGGILKLAGDLFALIGP-L 318
            .:|...:......::.|:.:...:..||    | :|..:....:..| .:.:|||    ...| .
Zfish   134 FESCEINRRRLAGLWEEEIRSRGNDASLRRVVWHFCRTRLLLSILCL-MVTQLAG----FSSPAF 193

  Fly   319 AIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLL 383
            .:.:::|     |.|.|||       ::...||....:|.||                      |
Zfish   194 VVWRLLE-----YTQRSEP-------DLPYGLLLVLGLLATE----------------------L 224

  Fly   384 ANGWCIAWIVLLAAITQGALSQASTHILN-MTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQ 447
            ...|                |.|.|..|| .||.|::.::..:.:.|.|.|
Zfish   225 IRSW----------------SHALTWALNYRTGTRLRGAILTMAFHKILRL-------------- 259

  Fly   448 VQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPF 512
                      :...:.||                  |.:.|..:.|.:.:.|...:.......|.
Zfish   260 ----------RSLREKSM------------------GELINMCSGDGQRMFEAAAVGSLLAGGPL 296

  Fly   513 KIAV--VIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVG 575
             :||  :.|.|:: ||.::::|| |..::..|...|.....:.........||:|::::::.|..
Zfish   297 -VAVLGMAYNLFV-LGPTSLLGS-AVFILFYPTMMFSSRLTAYFRRKGVAVTDQRVQKMNEILNY 358

  Fly   576 IKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQE 640
            ||.||:.||.:.|.:.::..|.:|.:.|.:...|.::...:..|..|:.:..|...::.|    .
Zfish   359 IKFIKMYAWVKAFSQAVRRIRDEERQILERTGYFQSITVGVAPIVVVIASVATFSTHMLL----G 419

  Fly   641 FDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARIL 705
            :||.|::.|:.:.:|..:|..|.:.|.:|..:..|.|:..|.:..|..:|::...|..||.:..:
Zfish   420 YDLTAAQAFTVVTVFNAMTFALKVTPFSVKSLSEASVAIDRFKSLLLMAEVKMIRELPRNPSVAV 484

  Fly   706 SKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPST 770
            ..|.||| .:||...|                  ||.|.
Zfish   485 EMSGASL-AWETGGHS------------------AQPSP-------------------------- 504

  Fly   771 VQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDI 835
                             |.||:|..|..:.:....:.|...:::....     ...||..:..::
Zfish   505 -----------------RGTPHVGTRGCRKKRRQRDVPKHHAILEEET-----HGQLLNDVSGEM 547

  Fly   836 AVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFW 900
            |.|..|........||.....||...:.:.||||..|.|..|||||||:||:|.:|.||.|
Zfish   548 ASSPKDQTLHVPTISQRLQRTLHCIDLSIQKGKLVGVCGSVGSGKTSLISAILGQMTLLEG---- 608

  Fly   901 HKTCTI----SYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGE 961
              |..:    :||:||.|:||.:.|:|||||:....:||..:|.||.|:||:.::|.|||:.|||
Zfish   609 --TVAVDGDFAYVAQQAWILNASFRDNILFGKEMEEERYQAILSACCLRPDLAMLPSGDLTEIGE 671

  Fly   962 RGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQ 1026
            ||.|:||||||||::|||:||:..:.|:||||::||..||.|||.:.|::.|:  .:|.|.||.|
Zfish   672 RGANLSGGQRQRISLARALYSNRGIYILDDPLSALDAHVGNHIFNNAIKKQLR--GKTVIFVTHQ 734

  Fly  1027 LHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERW 1091
            |..:.:.:.:|.::||.:...||:.|:..:.....|.:|
Zfish   735 LQYLVDCDDVIVMRDGSIAEQGSHEDLMNVNGDYAAMFN-------------------------- 773

  Fly  1092 KLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGG 1156

Zfish   774 ----------------------------------------------------------------- 773

  Fly  1157 FNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTAT 1221
             |||                                     ||
Zfish   774 -NLQ-------------------------------------LG---------------------- 778

  Fly  1222 SESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPP 1286
                                                                          ..|
Zfish   779 --------------------------------------------------------------ETP 781

  Fly  1287 AMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSI 1351
            .:||.|         ::|.:|.:.||:....||.::
Zfish   782 IIEVPN---------KKSGSSLKKPLEKSKAGSVKK----------------------------- 808

  Fly  1352 SEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSP 1416
             |:|           .|.|:....|.||:
Zfish   809 -EKS-----------TTQGDGQLMQVEER------------------------------------ 825

  Fly  1417 ADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRA-AGLPIITIFFITA 1480
                               |:.|:|.|                :|.:||:| .|.|:  ..||.|
Zfish   826 -------------------GKGSVPWA----------------VYKVYIQALGGWPV--FLFILA 853

  Fly  1481 LI------------WQCLRVYTDIWLQQWS-NVHGRVASKGHVVLHPSEQDHE-VTYYFRMYAAI 1531
            |.            |.|      .|::|.| |...:|.:..  ||..|.:|:. :.:|..:|...
Zfish   854 LFILNVGSTAFSNWWLC------YWIKQGSGNTTVQVGNSS--VLSESMRDNPLMQHYAAVYTMS 910

  Fly  1532 SCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKI 1596
            ..|.:::.|:...........|...|||:|.|.||...:.||..||..||:||||.||..:|.::
Zfish   911 MGVMLLLKLLRGIVFVKGTLRASSRLHDELFQKILRSPMKFFDTTPTARILNRFSKDMDEVDTRL 975

  Fly  1597 AATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVI 1661
            ....:...|..:|.|..:.:..::.||.||...|:...:.::....|...|||:|::|.|.||.:
Zfish   976 PFQAEMFTQNVILVLFCLAVIGSVFPWFLVAVGPLVLLFTVLHVVSRVFIRELKRLDNVTQSPFL 1040

  Fly  1662 SHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVT 1726
            ||::.:|||:||:.|:.::..|.....:.|:.|...:.|.:.:.|||.|.||.:.   |.:.::|
Zfish  1041 SHIASSIQGLTTVHAYGKEDEFLHRYQELLDQNQAPFYLFSCAMRWLAVRLDVIS---VALISIT 1102

  Fly  1727 ALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVV 1791
            ||....:    |.:.                           .|:..||||:|.:.:.....:.|
Zfish  1103 ALMIVLM----HGQI---------------------------PPAYAGLAISYAVQLTGLFQFTV 1136

  Fly  1792 KLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGD 1856
            :|.::.|....|||||.||.:....:|
Zfish  1137 RLASETEARFTSVERIHHYIKSLSLEA-------------------------------------- 1163

  Fly  1857 KVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHH 1921

Zfish  1164 ----------------------------------------------------------------- 1163

  Fly  1922 PPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDN 1986
                                                    |||  .:.::.|..|||.|:|.||.
Zfish  1164 ----------------------------------------PAR--VKNKAPPSDWPQEGEIVFDQ 1186

  Fly  1987 VSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIR 2051
            ..::|......::...:..:...::|||.|||||||||||:.|:.:::...|.|.||.|:|..|.
Zfish  1187 TEMKYRDNLPLILKKASFTVRPKEKIGIVGRTGSGKSSLGVVLYRLVEPCGGSIKIDGVNICDIG 1251

  Fly  2052 PDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDG 2116
            ..::|::||||||:..||:.|:|.||||...:.:.|:|:.||...:||.|: .|||.|::.:.:.
Zfish  1252 LADVRSKLSIIPQEPVLFSGTVRSNLDPFSQYSEAQIWDALERTHMKECVS-QLPLKLESEVVEN 1315

  Fly  2117 GLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTI 2181
            |.|.|.|.|||||:||.:||....|:|||||:.:.:.|:..:.:....||:..|.:|||||:.|:
Zfish  1316 GENFSVGERQLLCVARVLLRQCKILILDEATAAMGTETDCLIQETIRNAFQDCTTLTIAHRVHTV 1380

  Fly  2182 LDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLL 2216
            |..||::||:||::||...|.:|...|.|.|..:|
Zfish  1381 LSCDRIMVLNQGQVVEFDEPSKLLANENSRFCAML 1415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
abcc5	NP_001182542.1	intraplasmic N-terminal	1..59
		transmembrane domain 1	59..149		19/79 (24%)
		CFTR_protein	95..1419	CDD:273530	452/2023 (22%)
		ABC_membrane	177..441	CDD:294371	72/367 (20%)
		nucleotide binding domain 1	188..248		22/109 (20%)
		transmembrane domain 2	279..379		24/102 (24%)
		nucleotide binding domain 2	403..450		12/50 (24%)
		ABCC_MRP_domain1	552..751	CDD:213217	92/206 (45%)
		ABC_membrane	851..1132	CDD:294371	85/322 (26%)
		ABCC_MRP_domain2	1180..1400	CDD:213211	91/220 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010