Protein Alignment Sur and CG31793

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Alignment Length: 2021
• Identity: 455/2021 - (22%)
• Similarity: 720/2021 - (35%)
• Gaps: 780/2021 - (38%)

  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTE------KKKKSNSS 284
            |...|...|.:..|:|:.|.|:.|:..||.:...|..|.|..|.|...:.:      :|..|...
  Fly    14 AGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKGDSGRK 78

  Fly   285 PSLWYCYIKNSWQMFALGGILKLAGDLFA---LIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEV 346
            ||                 :|::.|.:|.   ::..:.|..:     :|..:|:.|
  Fly    79 PS-----------------VLRVIGRVFGWRLIMSGITIAAL-----ELGTRATVP--------- 112

  Fly   347 ANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHIL 411
              :||:.   |.:||.|....:....:||:               ::|:|.|....|   .||..
  Fly   113 --LLLAG---LISEFSEHGNGHSYNAQIYA---------------VLLIACILASVL---LTHPY 154

  Fly   412 NM----TGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVD 472
            .|    ..::::.::...||||:|.|       |..|.|...:
  Fly   155 MMGMMHLAMKMRVAVSSAIYRKALRL-------SRTSLGGTTT---------------------- 190

  Fly   473 NPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACI 537
                       |.:.|.::.|........:..|:.|..|.::.:..|.||..:|:::..| |:.:
  Fly   191 -----------GQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYG-ISIL 243

  Fly   538 VIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKY 602
            |:..|||.::....||.....|..||:|::.:::.:.||:|||:..|:..|.|.|.:.||.|:..
  Fly   244 VLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSS 308

  Fly   603 LNKDATFWTLMAVLTHIATVLITF-VTLG---VYVWLHRDQEF-----DLNASRLFSSLALFQQL 658
            :.:          :..:..:|::| :|||   ::|.|   ..|     :|.|.|.|...|.:..|
  Fly   309 IRQ----------MNLLRGILLSFEITLGRIAIFVSL---LGFVLGGGELTAERAFCVTAFYNIL 360

  Fly   659 --TVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKS 721
              ||. ..||..:.......||.||:..|:           :|..|.::..|:
  Fly   361 RRTVS-KFFPSGMSQFAELLVSMRRITNFM-----------MREEANVIDMSE------------ 401

  Fly   722 NMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRREL 786
                       |.:||...::....|:...|.|:....|       |.|:
  Fly   402 -----------RRDEKAEEEQHLLKEVEKRSYPVGIGKE-------PDTL--------------- 433

  Fly   787 LRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQ 851
                                  ||...:|||    |.::     ..|.:..::|..|
  Fly   434 ----------------------VEIKALRAR----WGQE-----QHDLVLNNVNMSL-------- 459

  Fly   852 MPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLL 916
                         .:|:|..|:|..||||:||:.|:|.|:|..:|::  ..:...||.||:|||.
  Fly   460 -------------RRGQLVAVIGPVGSGKSSLIQAILGELPPESGSV--QVSGKYSYASQEPWLF 509

  Fly   917 NDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIY 981
            |.::|:|||||.....:||..||:.|||:.|:||: .||.:|:||||.::|||||.||.:|||:|
  Fly   510 NASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVY 573

  Fly   982 SSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEA 1046
            ..|:|.::||||:::|..||.|:|..|:|..|.|  :..||||.||..:::|:.::.:..|.|.|
  Fly   574 RRADVYLLDDPLSAVDTHVGRHLFDECMRGFLGK--QLVILVTHQLQFLEDADLIVIMDKGHVSA 636

  Fly  1047 CGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMD 1111
            ||:|.:                 |.|:..|
  Fly   637 CGTYEE-----------------MLKSGQD----------------------------------- 649

  Fly  1112 ANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDV 1176
                                 .:.::.|..|.|          ||
  Fly   650 ---------------------FAQLLVESTQNS----------GG-------------------- 663

  Fly  1177 PLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSC 1241
                    ||::|..|              |.|.:.|.|||.::...|||:
  Fly   664 --------GDEIITSP--------------NLSRQSSALSTKSSNGSSSSL-------------- 692

  Fly  1242 SSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNT 1306
                ||.|:
  Fly   693 ----ESMVE-------------------------------------------------------- 697

  Fly  1307 SSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGN 1371
                                                                             
  Fly   698 ----------------------------------------------------------------- 697

  Fly  1372 KNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESG 1436
                  :||||                              .|:.:.||
  Fly   698 ------KEKPK------------------------------PSAVSSQE---------------- 710

  Fly  1437 RESMPLARLAIDTERKYGKISDDIYLMYIRA-AGLPIITIFFITALIWQCLRVYTDIWLQQWSNV 1500
                         .|..|:|...:|..|..| .|:.:..:..:..:..|.|....|.:|..|..
  Fly   711 -------------SRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVK- 761

  Fly  1501 HGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTI 1565
              ..||...:.:          |||   .||:...:|.||:.|........::...||:.:.|.:
  Fly   762 --NTASSSTLDI----------YYF---TAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGL 811

  Fly  1566 LHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLP 1630
            ....|:||...|.|||:|||:||:..:|:.:.|.....:|..|.....|.:.....||.|:.|..
  Fly   812 SRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFA 876

  Fly  1631 ICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFN-QQTRFTEI-LFKRLEA 1693
            :..|:|..:.||..::|:::|:|....||:.||.|.|:.|:.||||.. |||...:. .::.|.:
  Fly   877 MMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHS 941

  Fly  1694 NTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYA 1758
            :.. |..::|| |..|..||..  |:.:|.:|..           :.....|..:|..
  Fly   942 SGY-YTFVSTS-RAFGYYLDLF--CVAYVISVIL-----------HNFFNPPLHNAGQ------- 984

  Fly  1759 VTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADAD 1823
                          :||||...|.:...:.|.::..|::|....||||:..|.
  Fly   985 --------------IGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYK------------ 1023

  Fly  1824 ADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDC 1888
                                                        |:|.:||.
  Fly  1024 --------------------------------------------DLDPEGDF------------- 1031

  Fly  1889 GYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKD 1953
                                                                             
  Fly  1032 ----------------------------------------------------------------- 1031

  Fly  1954 KKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQN--VISNLTLKIPAGQRIGICG 2016
                  |.||.|     ..|.|||:.|.:...::|||||....:  |:..|:..|...:::||.|
  Fly  1032 ------NSPAEK-----QPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVG 1085

  Fly  2017 RTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHG 2081
            |||:|||||..:||. |....|.|.||.:|...|...:||:::|||||:..||:.|:|.||||..
  Fly  1086 RTGAGKSSLINALFR-LSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFE 1149

  Fly  2082 YFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEA 2146
            .:.|.:||..||...|||.:: .||.||.::|.:||.|.|.|.|||:||||||||.:..||:|||
  Fly  1150 QYPDDKLWKALEDVHLKEEIS-ELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEA 1213

  Fly  2147 TSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRE-LQQLEGS 2210
            |:.:|..|::.:.......|:..|::||||||.||:|.|:::|:|.|.:||.|:|.| |...:..
  Fly  1214 TANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAK 1278

  Fly  2211 VFRGLL 2216
            ||.|::
  Fly  1279 VFHGMV 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	86/398 (22%)
		TM helix 1	301..324	CDD:350035	4/25 (16%)
		TM helix 2	385..433	CDD:350035	12/51 (24%)
		TM helix 3	480..525	CDD:350035	9/44 (20%)
		TM helix 4	526..575	CDD:350035	13/48 (27%)
		TM helix 5	587..631	CDD:350035	11/47 (23%)
		TM helix 6	648..681	CDD:350035	9/34 (26%)
		ABCC_MRP_domain1	837..1043	CDD:213217	81/205 (40%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	86/337 (26%)
		TM helix 1	1475..1496	CDD:350046	4/20 (20%)
		TM helix 2	1520..1568	CDD:350046	12/47 (26%)
		TM helix 3	1575..1620	CDD:350046	14/44 (32%)
		TM helix 4	1621..1670	CDD:350046	17/48 (35%)
		TM helix 5	1682..1727	CDD:350046	11/45 (24%)
		TM helix 6	1777..1810	CDD:350046	9/32 (28%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	99/222 (45%)
CG31793	NP_609930.4	PLN03130	10..1305	CDD:215595	455/2021 (23%)