DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and abcc3

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	XP_009304645.1	Gene:	abcc3 / 323301	ZFINID:	ZDB-GENE-050517-16	Length:	1540	Species:	Danio rerio

Alignment Length:	2302	Identity:	534/2302 - (23%)
Similarity:	840/2302 - (36%)	Gaps:	891/2302 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ICGIDRVRRVFTFFSIFLLLFG-------------LMFVCSRYKKCHKTLLTFH---NGR----- 71
            :||.|:     .|:.:.|.|:|             |.:....|......|...|   |.|
Zfish     4 LCGPDK-----PFWELNLTLYGQQPDLPECFQMSVLSWAPCIYLWAAAPLYILHLRRNNRGYIMM 63

  Fly    72 -------AAISLLLLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTL 129
                   ..:.|:|..:...||...|  ||    :|:..:.||......:::|
Zfish    64 SILNRIKTVLGLILWIVCWTDLFSAF--HQ----MNQGSKISPIYFVTPLIVG------------ 110

  Fly   130 LTLMLMLYHRMVERKK-----ATVFLYASTAVEALTFALL----------SNELFELVRYEDF-L 178
            :|::|..:....||.|     ..:|::.:.:|   .||::          :.::.:.:|:..| :
Zfish   111 MTMLLATFLIQFERLKGVQSSGVLFIFWTLSV---VFAIVPFRSKIMHANTEQVKDKLRFTTFYI 172

  Fly   179 ELQTCLVAMSAMC------MVSLAMLDGLTVYKECYHDDYLDDYGKIGYKHSMATFYSKSCFWWL 237
            .....|:.:...|      :.|.|::|.    ..|              ..:.|.|.|:..|||.
Zfish   173 YFSFTLLELILSCFNEKPPLFSSAVMDP----NVC--------------PETTAGFLSRMTFWWF 219

  Fly   238 TPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSS------------------ 284
            |.:...|||.|||.:||..:...||:.......|..:..:|.|::||
Zfish   220 TRMAIKGYKSPLENKDLWSLNKNDSSELVVPGLLNQWEVEKSKAHSSDDQNVKEQVTFTKPGSGA 284

  Fly   285 -------------------------PSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIV 324
                                     ||..:..::.....|.:|...||..||...|.|..::.::
Zfish   285 ESNHVNESPEEAEVLLSKQQQKSRQPSFLWALLRAFGPYFLIGSAFKLLQDLITFINPQLLRMLI 349

  Fly   325 EYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCI 389
            .:.:|     |:.|                                      |.|      |:.:
Zfish   350 AFTKQ-----SDVP--------------------------------------SWW------GYAL 365

  Fly   390 AWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSST 454
            |:::...::.|..:.........:||:|::|.:.|.||||:|::                    |
Zfish   366 AFLMFGTSLLQTLILHQHFQYCFVTGMRLRTGIIGAIYRKALVI--------------------T 410

  Fly   455 SDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIY 519
            ::.|:                    |..:|.:.|.|:.|.:..|:....::..|:.|.:|.:.::
Zfish   411 NEAKR--------------------SSTVGEVVNLMSVDAQRFMDLTTFLNMLWSAPLQIFLALF 455

  Fly   520 LLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVI--AGYTDERLKRIHDTLVGIKVIKLN 582
            .|:.|||.| |:..:|.:|::.|...||  ||......:  ..|.|:|:|.:::.|.||||:||.
Zfish   456 FLWQNLGPS-VLAGVAVMVLLIPFNAFI--AMKTRTYQVEQMKYKDDRIKLMNEILNGIKVLKLY 517

  Fly   583 AWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASR 647
            ||:..|..||.:.|:|||..|.|.|....|..:....|..|:...:..|:|  :.|::..|:|.:
Zfish   518 AWEPSFRDKILQIRQKELHVLRKTAYLSALSTMAWTSAPFLVALTSFAVFV--NVDEKNVLDAEK 580

  Fly   648 LFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASL 712
            .|.||:||..|..||.:.|..:..|:.|.||.:||:.||...|                     |
Zfish   581 AFVSLSLFNILRFPLNMLPQVISSIVQASVSLKRLQDFLNHDE---------------------L 624

  Fly   713 DMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHN 777
            |......|||.|
Zfish   625 DPESVDRKSNTT----------------------------------------------------- 636

  Fly   778 KLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDG 842
                                                                    :.|||:.:|
Zfish   637 --------------------------------------------------------EYAVSVVNG 645

  Fly   843 LFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTIS 907
            .|:|..:.|:.:..::|   :||:|.|..|||..|.|||||:||||.||..|.|.:....  :::
Zfish   646 KFSWAKRDQVILDNINV---LVPQGSLLAVVGHVGCGKTSLISALLGEMEKLDGQISIRG--SVA 705

  Fly   908 YVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQ 972
            ||.||.|:.|.|:|:|||||..:..::|..|||||||.||:|::|.|||:.|||:|||:||||||
Zfish   706 YVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLSGGQRQ 770

  Fly   973 RIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLI 1037
            |:::|||:||.|:|.::||||:::|..|.:|||.|.|........:|.||||..:..:.:...::
Zfish   771 RVSLARALYSEADVYLLDDPLSAVDAHVAKHIFDHVIGPEGALKGKTRILVTHGISFLPQVNNIL 835

  Fly  1038 AIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGL 1102
            .:.||||...|||.|: |.|....||:                             |:|.|.
Zfish   836 VLVDGRVSEMGSYQDL-LRQNGAFAEF-----------------------------LRNYSL--- 867

  Fly  1103 QRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIY 1167
                           .|.|                 |||:::||:
Zfish   868 ---------------EDII-----------------EDDELTVSF-------------------- 880

  Fly  1168 GSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVL 1232
                         ||                                        |......|.|
Zfish   881 -------------DE----------------------------------------EEEEFPEDAL 892

  Fly  1233 SRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKK 1297
            |...          ..||.        ||.|
Zfish   893 SNHT----------DMVDN--------EPVV---------------------------------- 905

  Fly  1298 SEEARRSNTSSESPLDDHVRGSFQQFLRRMS-----------MRRSNKPKNHHHPLSATNSILSI 1351
             .||||                  ||:|:||           |.|..:.....||
Zfish   906 -NEARR------------------QFMRQMSIMSNDVENPKKMSRRRRCSERKHP---------- 941

  Fly  1352 SEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSP 1416
                                  ||.:|:|..|...:...|||
Zfish   942 ----------------------ETPTEKKEPKVEKLIQAETT----------------------- 961

  Fly  1417 ADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITAL 1481
                             |:||..:                  .:|..|::|.| |::.:|.  ..
Zfish   962 -----------------ETGRVKL------------------QVYWEYVKAIG-PLLALFI--CF 988

  Fly  1482 IWQC---LRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAA--------ISCVC 1535
            ::.|   ..:..:.||.:|:|          ..||...|:...| ...:|||        |..:|
Zfish   989 LYGCQSAAAIGANFWLSEWTN----------DALHNRTQEMLQT-RVGVYAALGISQGVLILSIC 1042

  Fly  1536 IIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATG 1600
            ::....||       ..|.|:.|..:|.::|.....||:.||.||::||||.|:..||..|....
Zfish  1043 LLCRAYST-------LRAARHTHQHMLNSVLRAPQAFFEATPSGRVLNRFSKDVDTIDSLIPDNI 1100

  Fly  1601 QRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLS 1665
            ...::.....::.:::...:||..|::.:|:...|:.:|:||..::|:|:|:|:.:.||:.||.|
Zfish  1101 DIWMRTFWYTVNVLMVCSVLTPIFLIVIVPLMLFYWWVQRFYVATSRQLKRLESVSRSPIYSHFS 1165

  Fly  1666 ETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTA 1730
            |:|.|.:.|||:.:...|..:...:::.|..:|.....|:|||||.::::|.|||..|.:.|:|.
Zfish  1166 ESITGTSVIRAYGRNAAFVLMSDNKVDENQKSYYPGIVSNRWLGVRIEFIGNCIVLFAALFAVTG 1230

  Fly  1731 ASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLA 1795
            ..                                  :.||.||||:::|.|.|.:.|||:|::.:
Zfish  1231 KD----------------------------------KLSPGLVGLSVSYALQVTMSLNWMVRMTS 1261

  Fly  1796 DMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYP 1860
            |:|....:|||:..|::.|
Zfish  1262 DLESNIVAVERVKEYSETQ---------------------------------------------- 1280

  Fly  1861 GATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPAT 1925
              |.|..:|.|
Zfish  1281 --TEAPWEVLE------------------------------------------------------ 1289

  Fly  1926 AGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLR 1990
                             |:.||                           .||..|::.|.:.|:|
Zfish  1290 -----------------KKPPP---------------------------DWPPLGNVEFVDYSVR 1310

  Fly  1991 YEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDEL 2055
            |......|:.|::||:..|::|||.||||:||||:.|.||.:|:...|.|.||||.|..|...:|
Zfish  1311 YREGLDLVLKNISLKVRGGEKIGIVGRTGAGKSSMTLCLFRLLEAAAGEIVIDDVKISEIGLHDL 1375

  Fly  2056 RTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNL 2120
            |::|:||||:..||:.|:|.||||...:.|.::|..|||:.|::||... ...|:....:||.||
Zfish  1376 RSKLTIIPQEPVLFSGTLRMNLDPFERYSDEEVWKALELSHLQKFVTNQ-AAKLELECSEGGENL 1439

  Fly  2121 SAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYD 2185
            |.|.|||:|||||:||.:..|||||||:.:|..|:..:.......|:..|:.||||||.||:||.
Zfish  1440 SVGQRQLVCLARALLRKTRILVLDEATAAVDLETDDLIQSTIRTEFQDCTVFTIAHRLNTIMDYT 1504

  Fly  2186 RLIVLDQGRIVEDGNPRELQQLEGSVF 2212
            |::|||:|:|.|...|..|...:|..|
Zfish  1505 RVLVLDKGQIAEFDTPTNLMNQKGLFF 1531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
abcc3	XP_009304645.1	MRP_assoc_pro	10..1539	CDD:188098	531/2291 (23%)
		ABC_membrane	330..595	CDD:279056	85/358 (24%)
		ABCC_MRP_domain1	640..841	CDD:213217	93/205 (45%)
		ABC_membrane	985..1253	CDD:279056	84/321 (26%)
		ABCC_MRP_domain2	1300..1520	CDD:213211	101/220 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010