Protein Alignment Sur and Abcc10

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001101671.1
• Gene: Abcc10 / 316231
• RGDID: 1306696
• Length: 1494
• Species: Rattus norvegicus
• Alignment Length: 2308
• Identity: 488/2308 - (21%)
• Similarity: 788/2308 - (34%)
• Gaps: 940/2308 - (40%)

  Fly    22 DNLNTDICGIDRVR-----------RVFTFFSIFLLLFGLMFVCSRYKKCH-------KTLLTFH 68
            :.|...:||.|..|           ..||...:.:|...|:.|.|   .||       ..:..|:
  Rat     2 EGLLAQLCGTDAARPLPLWEGDTTGHCFTQLVLSVLPHALLAVLS---ACHLGTPRTNNIIQPFN 63

  Fly    69 NG---RAAISLLLLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTLL 130
            .|   |...|.||......||..:.||                     .|...|.||..:.:..:
  Rat    64 PGWRLRLTASFLLSVFPLLDLLPVVLP---------------------PVSHPGPLWLEVLAGCV 107

  Fly   131 TLMLMLYHRMV-----------ERKKATVFLYASTAVEALTFALLSNELFELVRYEDFLELQTCL 184
            |.:....|.:.           .|....:.|.|.....||...||.:           .:..|.|
  Rat   108 TAVAWFTHSLALWALVHSPHGHSRGPLALALAAFLPTPALVLTLLWH-----------CQRGTFL 161

  Fly   185 V-----AMSAMCMVSLAMLDGLTVY----------KECY-HDDYLDDYGKIGYKHSMA----TFY 229
            .     .:..:|::.| .|..:..|          :|.: ||.:|....:   :..:|    ::.
  Rat   162 PPLLPGPLGRVCLLIL-QLAAVLAYGLGWAAPGGPREPWTHDPFLSPESQ---EREVAEDGESWL 222

  Fly   230 SKSCFWWLTPLLWLGYKEPLELEDLGQMKL-EDSAR-SHYDHFLYIYTEKKKKSNSSPSLW---- 288
            |:..:.||.|||..|.:        |:::. :|:.| ....|..|:....:........||
  Rat   223 SRFSYAWLAPLLARGVR--------GELRQPQDTCRLPRRLHPAYLARAFQAHWKEGAQLWRALY 279

  Fly   289 ----YCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANV 349
                .|||       || |:||:.|.:....|||.:..:|.::|    :..||        :::.
  Rat   280 GAFGCCYI-------AL-GLLKMVGTMLGFSGPLLLSLLVGFLE----EGQEP--------LSHG 324

  Fly   350 LLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMT 414
            ||   .:||                        ||:|      .:::|:.|   :|....:..:|
  Rat   325 LL---YVLG------------------------LASG------SVISAVLQ---NQYGYEVRKVT 353

  Fly   415 GIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNI 479
             ::.:.::..::|||:|.|                                       .||.|
  Rat   354 -LQARVAVLSILYRKTLKL---------------------------------------GPSRP-- 376

  Fly   480 SHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQ 544
              ..|.:.|.:..|:..::.|....|.||.:|.::|:.:||||..:|::.:.|.:..: ::.|:.
  Rat   377 --PTGEVLNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYEQVGVAFLAGLVLAL-LLVPVN 438

  Fly   545 FFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKEL------KYL 603
            ..|...:..|.:.:..:.|.|:|.:.:.|.||:|:|...|::....:::..|.:||      |||
  Rat   439 KVIATRIMANNQEMLRHKDARVKLMTELLSGIRVLKFFRWEQALGDRVKACRTQELGRLRVIKYL 503

  Fly   604 NKDATF-WTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPI 667
            :....: |..:.|:..| .:.||:|.||     |:     |.|:::|::|||...|.:||..||.
  Rat   504 DAACVYLWAALPVVICI-VIFITYVLLG-----HQ-----LTATKVFTALALVHMLILPLNNFPW 557

  Fly   668 TVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAEN 732
            .:..::.::||..|::||                          ||:
  Rat   558 VINGLLESKVSLDRIQRF--------------------------LDL------------------ 578

  Fly   733 RLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRP 797
                     .|.:||...:..|          ...||||.||
  Rat   579 ---------PSYSPEAYYSPDP----------PTEPSTVLEL----------------------- 601

  Fly   798 PKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQP--QSQMPVVQLHVP 860
                                                      ::.||:|.|  .||...:. |:.
  Rat   602 ------------------------------------------HEALFSWDPTGTSQKTFIS-HLQ 623

  Fly   861 GIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTIS----YVSQQPWLLNDTIR 921
               |.||.|..:|||.|.||:|||:|:..|:..|.|   |.....:|    ..:|:||:...|||
  Rat   624 ---VKKGMLVGIVGKVGCGKSSLLAAITGELHRLCG---WVAVSDLSKGFGLATQEPWIQCATIR 682

  Fly   922 ENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANV 986
            :|:|||::|..:.|..|||||||..|:.::|.||.:.:||:|:.:|||||.|||:|||:|....:
  Rat   683 DNVLFGKTFDAQLYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKTL 747

  Fly   987 VIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYA 1051
            .::|||||::|.:|..|:...||..:|..:.|  :|.|.:...::.|:.::.::.||:...|
  Rat   748 YLLDDPLAAVDADVANHLLHRCILGVLGHTTR--LLCTHRTEYLERADLVLLMEAGRLVRAG--- 807

  Fly  1052 DIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVAC 1116
                                                                             
  Rat   808 ----------------------------------------------------------------- 807

  Fly  1117 HADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPID 1181
                                                                             
  Rat   808 ----------------------------------------------------------------- 807

  Fly  1182 ECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAE 1246
                                                                             
  Rat   808 ----------------------------------------------------------------- 807

  Fly  1247 SSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESP 1311
                                 ||..:.            |.::.|...:...|:...|..|
  Rat   808 ---------------------PPSEIL------------PLVQAAPTALADKEQVTDSGQS---- 835

  Fly  1312 LDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQ 1376
                                                         |.||          |..:|.
  Rat   836 ---------------------------------------------PSVH----------NLEKTT 845

  Fly  1377 SEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMP 1441
            .|        :|..:.|                                         ||
  Rat   846 EE--------LDVAQNT-----------------------------------------SG----- 856

  Fly  1442 LARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQW--------S 1498
              ||..:..:..|.::..:|..|.||.|..:.|...|:.|:.|..|...|.||..|        :
  Rat   857 --RLVQEESKSEGAVALHVYRAYWRAMGSGLATAILISLLLMQATRNGADWWLAHWLSQLKAGRN 919

  Fly  1499 NVHGRVASKG-------------------HVVLH--PSEQDHEVTYYFRMYAAISCV---CIIMA 1539
            :...|.||..                   ::.||  .|....:|.:|..:||.|:.|   |.::.
  Rat   920 SSEERPASSSPRSMGFFSPRLLLFSPGNLYIPLHKATSNGSSDVHFYLTVYATIAGVNSLCTLLR 984

  Fly  1540 LVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLL 1604
            .|...||   ...|..:||.:||..:|...:.|:..||.||::||||:|:|.:|..:......||
  Rat   985 AVLFAAG---ALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILL 1046

  Fly  1605 QFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQ 1669
            ..::..|..:.:..:..||:|:|..|:...||.:|:.||.|.|||:|:.:.|.||:.|||::|:.
  Rat  1047 ANSVGLLGLLAVLGSGLPWLLLLLPPLSFIYYGVQRRYRASFRELRRLGSLTLSPLYSHLADTLA 1111

  Fly  1670 GVTTIRAFNQQTRFTEILFKRLEANT----IAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTA 1730
            |:..:||.....||.|...:.||.|.    .:||.:    :||.:.|..:|     .|.|:|:
  Rat  1112 GLPVLRAAGATYRFEEENQRLLELNQRCQFASYATM----QWLDIRLQLMG-----AAVVSAI-- 1165

  Fly  1731 ASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLA 1795
            |.::..:|.:...                         :|.||||.::|.|.:...|:.:|....
  Rat  1166 AGIALVQHQQGLA-------------------------NPGLVGLVLSYALSLTGLLSGLVSSFT 1205

  Fly  1796 DMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYP 1860
            ..|....||||:..|:                  .|:..||
  Rat  1206 QTEAMMVSVERLEEYS------------------CDIPQEP------------------------ 1228

  Fly  1861 GATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPAT 1925
                                                                       |..|
  Rat  1229 -----------------------------------------------------------HGQP-- 1232

  Fly  1926 AGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLR 1990
                                             |..|.::        :||..:|.:.|.:|.|.
  Rat  1233 ---------------------------------PQSPHQR--------VSWLTQGSVEFQDVVLV 1256

  Fly  1991 YEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDEL 2055
            |.....|.:..:|.::..|:::||.||||||||||.|.||.:|:.:.|.:.:|.||..::...||
  Rat  1257 YRPGLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPSAGQVLLDGVDTSQLELAEL 1321

  Fly  2056 RTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPL-GLDTVICDGGLN 2119
            |::|::|||:..||:.|:||||||.|..:|..||..||...|.|..   :.: |||..:.:.|.:
  Rat  1322 RSQLAVIPQEPFLFSGTVRENLDPQGLHEDRALWQALEQCHLSEVA---MAIGGLDGELGERGRD 1383

  Fly  2120 LSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDY 2184
            ||.|.|||||||||:|..:..|.:||||:.:|..|:..|.:.....|..:|::||||||.|||:.
  Rat  1384 LSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICRRFANKTVLTIAHRLNTILNS 1448

  Fly  2185 DRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLE 2217
            ||::||..||:||..:|..|:....|:||.||:
  Rat  1449 DRVLVLQAGRVVELDSPSALRNQPHSLFRQLLQ 1481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	86/387 (22%)
		TM helix 1	301..324	CDD:350035	8/22 (36%)
		TM helix 2	385..433	CDD:350035	9/47 (19%)
		TM helix 3	480..525	CDD:350035	13/44 (30%)
		TM helix 4	526..575	CDD:350035	9/48 (19%)
		TM helix 5	587..631	CDD:350035	13/50 (26%)
		TM helix 6	648..681	CDD:350035	11/32 (34%)
		ABCC_MRP_domain1	837..1043	CDD:213217	79/211 (37%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	101/371 (27%)
		TM helix 1	1475..1496	CDD:350046	7/20 (35%)
		TM helix 2	1520..1568	CDD:350046	16/50 (32%)
		TM helix 3	1575..1620	CDD:350046	14/44 (32%)
		TM helix 4	1621..1670	CDD:350046	22/48 (46%)
		TM helix 5	1682..1727	CDD:350046	14/48 (29%)
		TM helix 6	1777..1810	CDD:350046	9/32 (28%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	96/221 (43%)
Abcc10	NP_001101671.1	MRP_assoc_pro	201..1471	CDD:188098	440/2061 (21%)