Protein Alignment Sur and Abcc10

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001101671.1
• Gene: Abcc10 / 316231
• RGDID: 1306696
• Length: 1494
• Species: Rattus norvegicus
• Alignment Length: 2308
• Identity: 488/2308 - (21%)
• Similarity: 788/2308 - (34%)
• Gaps: 940/2308 - (40%)

  Fly    22 DNLNTDICGIDRVR-----------RVFTFFSIFLLLFGLMFVCSRYKKCH-------KTLLTFH 68
            :.|...:||.|..|           ..||...:.:|...|:.|.|   .||       ..:..|:
  Rat     2 EGLLAQLCGTDAARPLPLWEGDTTGHCFTQLVLSVLPHALLAVLS---ACHLGTPRTNNIIQPFN 63

  Fly    69 NG---RAAISLLLLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTLL 130
            .|   |...|.||......||..:.||                     .|...|.||..:.:..:
  Rat    64 PGWRLRLTASFLLSVFPLLDLLPVVLP---------------------PVSHPGPLWLEVLAGCV 107

  Fly   131 TLMLMLYHRMV-----------ERKKATVFLYASTAVEALTFALLSNELFELVRYEDFLELQTCL 184
            |.:....|.:.           .|....:.|.|.....||...||.:           .:..|.|
  Rat   108 TAVAWFTHSLALWALVHSPHGHSRGPLALALAAFLPTPALVLTLLWH-----------CQRGTFL 161

  Fly   185 V-----AMSAMCMVSLAMLDGLTVY----------KECY-HDDYLDDYGKIGYKHSMA----TFY 229
            .     .:..:|::.| .|..:..|          :|.: ||.:|....:   :..:|    ::.
  Rat   162 PPLLPGPLGRVCLLIL-QLAAVLAYGLGWAAPGGPREPWTHDPFLSPESQ---EREVAEDGESWL 222

  Fly   230 SKSCFWWLTPLLWLGYKEPLELEDLGQMKL-EDSAR-SHYDHFLYIYTEKKKKSNSSPSLW---- 288
            |:..:.||.|||..|.:        |:::. :|:.| ....|..|:....:........||
  Rat   223 SRFSYAWLAPLLARGVR--------GELRQPQDTCRLPRRLHPAYLARAFQAHWKEGAQLWRALY 279

  Fly   289 ----YCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANV 349
                .|||       || |:||:.|.:....|||.:..:|.::|    :..||        :::.
  Rat   280 GAFGCCYI-------AL-GLLKMVGTMLGFSGPLLLSLLVGFLE----EGQEP--------LSHG 324

  Fly   350 LLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMT 414
            ||   .:||                        ||:|      .:::|:.|   :|....:..:|
  Rat   325 LL---YVLG------------------------LASG------SVISAVLQ---NQYGYEVRKVT 353

  Fly   415 GIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNI 479
             ::.:.::..::|||:|.|                                       .||.|
  Rat   354 -LQARVAVLSILYRKTLKL---------------------------------------GPSRP-- 376

  Fly   480 SHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQ 544
              ..|.:.|.:..|:..::.|....|.||.:|.::|:.:||||..:|::.:.|.:..: ::.|:.
  Rat   377 --PTGEVLNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYEQVGVAFLAGLVLAL-LLVPVN 438

  Fly   545 FFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKEL------KYL 603
            ..|...:..|.:.:..:.|.|:|.:.:.|.||:|:|...|::....:::..|.:||      |||
  Rat   439 KVIATRIMANNQEMLRHKDARVKLMTELLSGIRVLKFFRWEQALGDRVKACRTQELGRLRVIKYL 503

  Fly   604 NKDATF-WTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPI 667
            :....: |..:.|:..| .:.||:|.||     |:     |.|:::|::|||...|.:||..||.
  Rat   504 DAACVYLWAALPVVICI-VIFITYVLLG-----HQ-----LTATKVFTALALVHMLILPLNNFPW 557

  Fly   668 TVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAEN 732
            .:..::.::||..|::||                          ||:
  Rat   558 VINGLLESKVSLDRIQRF--------------------------LDL------------------ 578

  Fly   733 RLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRP 797
                     .|.:||...:..|          ...||||.||
  Rat   579 ---------PSYSPEAYYSPDP----------PTEPSTVLEL----------------------- 601

  Fly   798 PKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQP--QSQMPVVQLHVP 860
                                                      ::.||:|.|  .||...:. |:.
  Rat   602 ------------------------------------------HEALFSWDPTGTSQKTFIS-HLQ 623

  Fly   861 GIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTIS----YVSQQPWLLNDTIR 921
               |.||.|..:|||.|.||:|||:|:..|:..|.|   |.....:|    ..:|:||:...|||
  Rat   624 ---VKKGMLVGIVGKVGCGKSSLLAAITGELHRLCG---WVAVSDLSKGFGLATQEPWIQCATIR 682

  Fly   922 ENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANV 986
            :|:|||::|..:.|..|||||||..|:.::|.||.:.:||:|:.:|||||.|||:|||:|....:
  Rat   683 DNVLFGKTFDAQLYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKTL 747

  Fly   987 VIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYA 1051
            .::|||||::|.:|..|:...||..:|..:.|  :|.|.:...::.|:.::.::.||:...|
  Rat   748 YLLDDPLAAVDADVANHLLHRCILGVLGHTTR--LLCTHRTEYLERADLVLLMEAGRLVRAG--- 807

  Fly  1052 DIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVAC 1116
                                                                             
  Rat   808 ----------------------------------------------------------------- 807

  Fly  1117 HADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPID 1181
                                                                             
  Rat   808 ----------------------------------------------------------------- 807

  Fly  1182 ECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAE 1246
                                                                             
  Rat   808 ----------------------------------------------------------------- 807

  Fly  1247 SSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESP 1311
                                 ||..:.            |.::.|...:...|:...|..|
  Rat   808 ---------------------PPSEIL------------PLVQAAPTALADKEQVTDSGQS---- 835

  Fly  1312 LDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQ 1376
                                                         |.||          |..:|.
  Rat   836 ---------------------------------------------PSVH----------NLEKTT 845

  Fly  1377 SEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMP 1441
            .|        :|..:.|                                         ||
  Rat   846 EE--------LDVAQNT-----------------------------------------SG----- 856

  Fly  1442 LARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQW--------S 1498
              ||..:..:..|.::..:|..|.||.|..:.|...|:.|:.|..|...|.||..|        :
  Rat   857 --RLVQEESKSEGAVALHVYRAYWRAMGSGLATAILISLLLMQATRNGADWWLAHWLSQLKAGRN 919

  Fly  1499 NVHGRVASKG-------------------HVVLH--PSEQDHEVTYYFRMYAAISCV---CIIMA 1539
            :...|.||..                   ::.||  .|....:|.:|..:||.|:.|   |.::.
  Rat   920 SSEERPASSSPRSMGFFSPRLLLFSPGNLYIPLHKATSNGSSDVHFYLTVYATIAGVNSLCTLLR 984

  Fly  1540 LVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLL 1604
            .|...||   ...|..:||.:||..:|...:.|:..||.||::||||:|:|.:|..:......||
  Rat   985 AVLFAAG---ALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILL 1046

  Fly  1605 QFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQ 1669
            ..::..|..:.:..:..||:|:|..|:...||.:|:.||.|.|||:|:.:.|.||:.|||::|:.
  Rat  1047 ANSVGLLGLLAVLGSGLPWLLLLLPPLSFIYYGVQRRYRASFRELRRLGSLTLSPLYSHLADTLA 1111

  Fly  1670 GVTTIRAFNQQTRFTEILFKRLEANT----IAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTA 1730
            |:..:||.....||.|...:.||.|.    .:||.:    :||.:.|..:|     .|.|:|:
  Rat  1112 GLPVLRAAGATYRFEEENQRLLELNQRCQFASYATM----QWLDIRLQLMG-----AAVVSAI-- 1165

  Fly  1731 ASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLA 1795
            |.::..:|.:...                         :|.||||.::|.|.:...|:.:|....
  Rat  1166 AGIALVQHQQGLA-------------------------NPGLVGLVLSYALSLTGLLSGLVSSFT 1205

  Fly  1796 DMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYP 1860
            ..|....||||:..|:                  .|:..||
  Rat  1206 QTEAMMVSVERLEEYS------------------CDIPQEP------------------------ 1228

  Fly  1861 GATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPAT 1925
                                                                       |..|
  Rat  1229 -----------------------------------------------------------HGQP-- 1232

  Fly  1926 AGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLR 1990
                                             |..|.::        :||..:|.:.|.:|.|.
  Rat  1233 ---------------------------------PQSPHQR--------VSWLTQGSVEFQDVVLV 1256

  Fly  1991 YEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDEL 2055
            |.....|.:..:|.::..|:::||.||||||||||.|.||.:|:.:.|.:.:|.||..::...||
  Rat  1257 YRPGLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPSAGQVLLDGVDTSQLELAEL 1321

  Fly  2056 RTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPL-GLDTVICDGGLN 2119
            |::|::|||:..||:.|:||||||.|..:|..||..||...|.|..   :.: |||..:.:.|.:
  Rat  1322 RSQLAVIPQEPFLFSGTVRENLDPQGLHEDRALWQALEQCHLSEVA---MAIGGLDGELGERGRD 1383

  Fly  2120 LSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDY 2184
            ||.|.|||||||||:|..:..|.:||||:.:|..|:..|.:.....|..:|::||||||.|||:.
  Rat  1384 LSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICRRFANKTVLTIAHRLNTILNS 1448

  Fly  2185 DRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLE 2217
            ||::||..||:||..:|..|:....|:||.||:
  Rat  1449 DRVLVLQAGRVVELDSPSALRNQPHSLFRQLLQ 1481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
Abcc10	NP_001101671.1	CFTR_protein	211..1485	CDD:273530	442/2060 (21%)
		ABC_membrane	290..552	CDD:294371	79/365 (22%)
		ABCC_MRP_domain1	599..802	CDD:213217	81/276 (29%)
		ABC_membrane	957..1190	CDD:294371	79/271 (29%)
		PBP2_NikA_DppA_OppA_like	<1201..>1274	CDD:294989	23/216 (11%)
		ABCC_MRP_domain2	1246..1465	CDD:213211	96/221 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010