Protein Alignment Sur and Abcc9

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_037172.2
• Gene: Abcc9 / 25560
• RGDID: 3787
• Length: 1545
• Species: Rattus norvegicus
• Alignment Length: 2246
• Identity: 555/2246 - (24%)
• Similarity: 865/2246 - (38%)
• Gaps: 774/2246 - (34%)

  Fly    19 SIYDNLNTDICGIDR---VRRVFTFFSIFLLLF-GLMFVCSRYKKCHKTLLTF--HNGRAAISLL 77
            :||..:..:.|.:|.   |..||..|..|.:|| |.....|:.:..|.|.|.|  ||.|..::..
  Rat    14 NIYHGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFA 78

  Fly    78 LLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVE 142
            ||.::..::|...:...         |.:.|.|:..:        .|:...:.|...::|:..:|
  Rat    79 LLFVHVCEIAEGIVSDS---------QRASRHLHLFM--------PAVMGFVATTTSIVYYHNIE 126

  Fly   143 RKKATVFLYASTAVEALTFALLSNELFELVRYED----FLELQTCLVAMSAMCMVSLAMLDGLTV 203
            .......|.|......:.|.   .:..:||:|..    ..:|:.|:..:       :.:|:||.:
  Rat   127 TSNFPKLLLALFLYWVMAFI---TKTIKLVKYWQLGWGMSDLRFCITGV-------MVILNGLLM 181

  Fly   204 YKE-----------------CYHDDYLDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLEL 251
            ..|                 ....:.|.|.| :.:........||:.:||:..|:...:::|::|
  Rat   182 AVEINVIRVRRYVFFMNPQKVKPPEDLQDLG-VRFLQPFVNLLSKATYWWMNTLIISAHRKPIDL 245

  Fly   252 EDLGQMKLEDSARSHYDHFLYIYTEKKKKS----NSSPSLWYCYIKNSWQMFALGGILKLAGDLF 312
            :.:|::.:...|.::|......|.|:|||:    |.:||:|....:...:...|....:...||.
  Rat   246 KAIGKLPIAMRAVTNYVCLKEAYEEQKKKAADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLL 310

  Fly   313 ALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSS 377
            ...|||.|..||:.:.:            |.|..            |.|.|...:
  Rat   311 GFAGPLCISGIVQRVNE------------PKNNT------------TRFSETLSS---------- 341

  Fly   378 TWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSS 442
              .:.|.|...:|.::.||.|.|....|||.::...|||.::.:|..:||.|.|.|:.     |:
  Rat   342 --KEFLENAHVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLST-----SN 399

  Fly   443 DSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYA 507
            .|.|::                                 .:|.|.|.:..:|..:|.|..:....
  Rat   400 LSMGEM---------------------------------TLGQINNLVAIETNQLMWFLFLCPNL 431

  Fly   508 WAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDT 572
            ||:|.:|.:.:.|||..||.||::|: |.||::.|:|:||...:::..:....|:.||||:.::.
  Rat   432 WAMPVQIIMGVILLYNLLGSSALVGA-AVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEI 495

  Fly   573 LVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTL---MAVLTHIATVLITFVTLGVYVW 634
            |.|||::||.||:.:|.|.::|.|.|||..|...|.:.:|   |.....||.||.||||   :.:
  Rat   496 LKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT---HAY 557

  Fly   635 LHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIR 699
            ...:   :|..:..|:||:||..|..||.:....|...:.|.:|.::|..||.|.||.:
  Rat   558 ASGN---NLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGE------ 613

  Fly   700 NMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAE 764
                         |.:.|.| ..:...:.:....:..|.:.:|
  Rat   614 -------------DSWRTGE-GTLPFESCKKHTGVQSKPINRK---------------------- 642

  Fly   765 DISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLL 829
              .|...    |....:|.|.|                    ||.|
  Rat   643 --QPGRY----HLDNYEQARRL--------------------RPAE------------------- 662

  Fly   830 KMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLL 894
              .:|:|:.:.:|.|:|    ...:..|....|.:|.|:||::||:.|.||:|||.|:|.||..|
  Rat   663 --TEDVAIKVTNGYFSW----GSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTL 721

  Fly   895 AGNMFWHKT---------------CTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACAL 944
            .|.::|:..               .:::|.:|:|||||.|:.|||.||.||..:||..|.:||:|
  Rat   722 EGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSSFNRQRYKAVTDACSL 786

  Fly   945 KPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCI 1009
            :|||:|:|.||.:.|||||||:||||||||.:|||:|.:.|:|.:|||.::||..:.:|:.|..|
  Rat   787 QPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGI 851

  Fly  1010 REMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAK 1074
            .:.||...||.:|||.:|..:..|:::||:|||.|...|:..||:.....:.
  Rat   852 LKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELY------------- 903

  Fly  1075 NDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEE 1139
                          |.||.|.|.....|::.:                                |
  Rat   904 --------------EHWKTLMNRQDQELEKDM--------------------------------E 922

  Fly  1140 DDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSR 1204
            .||.:              |:||.     .|..||
  Rat   923 ADQTT--------------LERKT-----LRRAMY------------------------------ 938

  Fly  1205 NTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPP 1269
                                                                             
  Rat   939 ----------------------------------------------------------------- 938

  Fly  1270 QHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNK 1334
                                        |.||:       :.::|
  Rat   939 ----------------------------SREAK-------AQMED-------------------- 948

  Fly  1335 PKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDN 1399
                                                 ::|.:.||:.:              |||
  Rat   949 -------------------------------------EDEEEEEEEDE--------------DDN 962

  Fly  1400 CYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMY 1464
            ..:.    :|.                          |..||....                ..|
  Rat   963 MSTV----MRL--------------------------RTKMPWKTC----------------WWY 981

  Fly  1465 IRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYA 1529
            :.:.|..::.:...:.|:...:.|..|.||..|::.:.        :..|.:.|.  |:|   .|
  Rat   982 LTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYS--------INDPGKADQ--TFY---VA 1033

  Fly  1530 AISCVC---IIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAV 1591
            ..|.:|   |.:.||::...::.|..|.:|||..||..|:...:.||..||||.|:||||.|..:
  Rat  1034 GFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNI 1098

  Fly  1592 IDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENAT 1656
            ||:.|..|.:.|.:.||||||||.:....||..|:...|:..|:|.|||::|.::::||.::::|
  Rat  1099 IDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELDDST 1163

  Fly  1657 NSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVF 1721
            ..|::.|.|||.:|:||||||..:|||.:.:.:..:.|.|||..|:.::|||.|..||||.|||.
  Rat  1164 QLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVL 1228

  Fly  1722 VATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIY 1786
            .|::.:::.:|.|                                    .||||.:.|.|.:..|
  Rat  1229 TASIASISGSSNS------------------------------------GLVGLGLLYALTITNY 1257

  Fly  1787 LNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQ 1851
            |||||:.|||:|:..|:|:::                               |..::.|.:.
  Rat  1258 LNWVVRNLADLEVQMGAVKKV-------------------------------NSFLTMESEN--- 1288

  Fly  1852 SDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNH 1916
                   |.|.
  Rat  1289 -------YEGT------------------------------------------------------ 1292

  Fly  1917 LNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGD 1981
                                        :.|.|                      ||..|||.|:
  Rat  1293 ----------------------------MDPSQ----------------------VPEHWPQEGE 1307

  Fly  1982 IHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVD 2046
            |...::.:|||...:.|:.::...|..||::|||||||||||||.|:.|.::....|.|.||.:|
  Rat  1308 IKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGID 1372

  Fly  2047 IQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDT 2111
            |.::....||:|||||.||..||:.:||.||||.....|.:||..||:||||..|.. ||.|||.
  Rat  1373 ISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKS-LPGGLDA 1436

  Fly  2112 VICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAH 2176
            .:.:||.|.|.|.|||.|||||.:|.|..|::||||:.:|.:||:.|.|....||..||::||||
  Rat  1437 TVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAH 1501

  Fly  2177 RLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVF 2212
            |:.|||..|.:||:.:|.|:|...|..|...|..||
  Rat  1502 RVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVF 1537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
Abcc9	NP_037172.2	MRP_assoc_pro	222..1542	CDD:188098	510/2010 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	940..963		8/100 (8%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3623
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56521
Inparanoid	1	1.050	772	1.000	Inparanoid score	I512
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.060