Protein Alignment Sur and abc2

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_593943.3
• Gene: abc2 / 2543193
• PomBaseID: SPAC3F10.11C
• Length: 1478
• Species: Schizosaccharomyces pombe
• Alignment Length: 2238
• Identity: 485/2238 - (21%)
• Similarity: 816/2238 - (36%)
• Gaps: 843/2238 - (37%)

  Fly    38 FTFFS-------IFLLLFGLMFVCSRY-----KKCHKTLLTFHNGR-------AAISLLLLALNS 83
            |||.|       |:||:.|    |.:|     |:.|    .||..|       :.:.::||..:.
pombe    23 FTFLSATWLAPNIYLLISG----CLQYFYEVRKRSH----YFHFRRFWTIWLKSLVIMVLLFTHI 79

  Fly    84 FDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKATV 148
            :|..:.                            :..:||.|  :::|..|.|:..:||  :.|:
pombe    80 YDCYKT----------------------------NESVWNVL--SIITYFLALFLHVVE--QPTL 112

  Fly   149 FLYASTAVEALTFALLSNELFELVR--YEDFLELQT-------CLVAMSAMCMVSLAMLDGLTVY 204
            .:..::.:....|..|::.|..|:|  |..|..|..       |    |.:|:::       .:|
pombe   113 RIPMASLLMFWLFKFLASALVLLLRPNYTMFPMLNVVPSITFFC----SLVCLLA-------EIY 166

  Fly   205 -----KECYHDD--YLDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDS 262
                 :..|.||  .|::.|....:.:.|..:|:..|.||:||:..||:..|...|  ...|..:
pombe   167 VPPANRVWYPDDAAELEETGLRPSRFTYANIFSRISFGWLSPLMKFGYRNYLTESD--AWSLPPA 229

  Fly   263 ARSHYDHFLYIYTEKK-----KKSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQK 322
            .||..   |.|..||.     ||..||..:|.....|.|::..:..:|||..|:.|.|.|..|:|
pombe   230 ERSSN---LTIVFEKNWISHAKKKKSSLYMWGVLFLNHWKLTVVIIVLKLVQDVVAFIQPNLIRK 291

  Fly   323 IVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGW 387
            ||.::....::..:||..                                             |:
pombe   292 IVIFVSSYSSEHPQPPQV---------------------------------------------GF 311

  Fly   388 CIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTS 452
            .:|..:.|..:.|.||.|....:..:.|:|.::.|...||||||.|        |.:|.|
pombe   312 SLAIAMFLTNVVQTALLQQYFQLGMVLGMRWRSELITAIYRKSLRL--------SSAARQ----- 363

  Fly   453 STSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVV 517
                                       |..:|.|.|:|:.||:.:.:..:.:....:.||:|.:.
pombe   364 ---------------------------SRSVGDIVNYMSVDTQKVCDLTMFLFVIVSGPFQIVLA 401

  Fly   518 IYLLYMNLGISAVIGSIA------CIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGI 576
            :..||..:|..|:.|:..      |.|::..:.....|...||       .|.|.:.:.:.:..|
pombe   402 LTNLYHLVGYGALSGAFVTFLLFPCNVVIASIFKRFQNRQMKN-------KDARSQFMTEIINNI 459

  Fly   577 KVIKLNAWDEVFLKKIQEARR-KELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQE 640
            :.|||.||:.:||:|:.:.|. :||:.|.|.....|:.......|.:|::..|.|.::.|:....
pombe   460 RSIKLYAWENIFLQKLLQLRNTRELRMLKKIGIVNTIGNFTWLFAPILVSAATFGTFIVLYGKTR 524

  Fly   641 FDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARIL 705
            . |:...:|:.|:||..|..||.:.||.|..::.|.|:..|:..||.:.|:..
pombe   525 V-LSVDIVFACLSLFNLLQFPLTMLPIVVSSVLEASVAISRIYGFLTAGELDS------------ 576

  Fly   706 SKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPST 770
                                                                           :.
pombe   577 ---------------------------------------------------------------NA 578

  Fly   771 VQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDI 835
            ||....|                                                    |.|..:
pombe   579 VQRYPAN----------------------------------------------------KEPSGV 591

  Fly   836 AVSINDGLFTWQ-PQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMF 899
            .:.|..|.|:|. |........|.....:..:|:|..:|||.|.||:|||.|.|..|...:|::|
pombe   592 CLEIKKGTFSWSGPGQNAAEPTLRDIDFVARRGELCCIVGKVGMGKSSLLEACLGNMQKHSGSVF 656

  Fly   900 WHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGI 964
              :..:|:|.:||||:||.||:||||||....|:.|:..:.||.|..|.|::..||.:.:||:||
pombe   657 --RCGSIAYAAQQPWILNATIQENILFGLELDPEFYEKTIRACCLLRDFEILADGDQTEVGEKGI 719

  Fly   965 NISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKS----NRTFILVTQ 1025
            ::||||:.||::|||:||.:::.::||.|:::|    :|:.:..:|.:|...    :|..||.|.
pombe   720 SLSGGQKARISLARAVYSRSDIYLLDDILSAVD----QHVNRDLVRNLLGSKGLLRSRCVILSTN 780

  Fly  1026 QLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGER 1090
            .|..:|||..:..:::|::...||:..:                         |.:|.    .:.
pombe   781 SLTVLKEASMIYMLRNGKIIESGSFTQL-------------------------SSSPD----SQL 816

  Fly  1091 WKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCG 1155
            ::||...||
pombe   817 FQLLSEFSK-------------------------------------------------------- 825

  Fly  1156 GFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTA 1220
                                                            ::|.||   :|..|
pombe   826 ------------------------------------------------KDTASS---TGADT--- 836

  Fly  1221 TSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSP 1285
                                                                    ||||:.|
pombe   837 --------------------------------------------------------PLSRSQS-- 843

  Fly  1286 PAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILS 1350
              :..::.||          |||.|...|.|               ||.||
pombe   844 --VITSSTDV----------TSSASRSSDTV---------------SNYPK-------------- 867

  Fly  1351 ISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSS 1415
                        |:|..|...:.....|:..|                             .|..
pombe   868 ------------ATIKGTGRIRKRLTDEDNVK-----------------------------ATGQ 891

  Fly  1416 PADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITA 1480
            .|::.:.                               ||:...:|..|.:|..|.:|.::|:..
pombe   892 AAEKMER-------------------------------GKVKWKVYWTYFKACSLFLIFLYFLFI 925

  Fly  1481 LIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCV-CIIMALVSTP 1544
            :....:.|.|::||:.||.|:.::.      .:|...     :|..:|.....: |.:::|.|..
pombe   926 IGGIGMNVGTNVWLKHWSEVNTQLG------YNPKPY-----FYLGIYTLFGLLSCALISLSSLT 979

  Fly  1545 AGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLL 1609
            ...:....:.|.|||.:::.:|...:.||:.||.|||:||||:|:..:|:.|:    |:..|...
pombe   980 ITVFCAIKSCRYLHDSMVKAVLRAPMSFFETTPTGRILNRFSSDVYRVDEVIS----RVFMFFFR 1040

  Fly  1610 CLSAILINVTI----TPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQG 1670
            .|..|:..:.:    :|..::|.:|:...|...|.:|..::|||:|:::.|.||:.:|..|::.|
pombe  1041 NLFQIVFVLAVICYSSPMFMILIVPLFFLYRYNQVYYTQTSRELKRLDSVTRSPLYAHFQESLGG 1105

  Fly  1671 VTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSC 1735
            ::||||::.:..|......|::.|...:.|..:|:||..:.::.:|..:||
pombe  1106 LSTIRAYDMEDTFISENDIRVDTNHRIWFLYFSSNRWQAIRVEAIGALVVF-------------- 1156

  Fly  1736 RRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMY 1800
                          |.:.|...:..:.    .|:..||||:::|.:.:...|.:||:...|:|..
pombe  1157 --------------SSAFFGVLSAVRG----NPNSGLVGLSLSYAVQITQSLTFVVRQSVDVETN 1203

  Fly  1801 AGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTA 1865
            ..||||:..|. |..::|                 ||...|
pombe  1204 IVSVERMLEYI-GLPSEA-----------------PSIIPD------------------------ 1226

  Fly  1866 AGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKV 1930
                                                                  |.||.
pombe  1227 ------------------------------------------------------HRPPE------ 1231

  Fly  1931 EQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQK 1995
                                                        .||..|.|.||:.|:||....
pombe  1232 --------------------------------------------GWPSHGAIKFDHYSVRYRENL 1252

  Fly  1996 QNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLS 2060
            ..|::::::.|...::|||.||||:|||:|.|:||.:::.|.|.|.:||::|..|...:||:||:
pombe  1253 PLVLNDISVNIKPQEKIGIVGRTGAGKSTLTLALFRLIEPTSGDIQLDDINITSIGLHDLRSRLA 1317

  Fly  2061 IIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHR 2125
            ||||:...|..||||||||:....|.::|:.||.|.||:|:. .|..||.:.:.:||.|||:|.|
pombe  1318 IIPQENQAFEGTIRENLDPNANATDEEIWHALEAASLKQFIQ-TLDGGLYSRVTEGGANLSSGQR 1381

  Fly  2126 QLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVL 2190
            ||:||.||:|..:..|:|||||:.:|..|::.:.:.....|..|||:|||||:.|::|.:|::||
pombe  1382 QLMCLTRALLTPTRVLLLDEATAAVDVETDAIVQRTIRERFNDRTILTIAHRINTVMDSNRILVL 1446

  Fly  2191 DQGRIVEDGNPRELQQLEGSVFRGLLEK 2218
            |.|::||..:.::|.:.:.|:|..|.::
pombe  1447 DHGKVVEFDSTKKLLENKASLFYSLAKE 1474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	88/387 (23%)
		TM helix 1	301..324	CDD:350035	9/22 (41%)
		TM helix 2	385..433	CDD:350035	16/47 (34%)
		TM helix 3	480..525	CDD:350035	12/44 (27%)
		TM helix 4	526..575	CDD:350035	10/54 (19%)
		TM helix 5	587..631	CDD:350035	12/44 (27%)
		TM helix 6	648..681	CDD:350035	12/32 (38%)
		ABCC_MRP_domain1	837..1043	CDD:213217	77/210 (37%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	84/340 (25%)
		TM helix 1	1475..1496	CDD:350046	5/20 (25%)
		TM helix 2	1520..1568	CDD:350046	10/48 (21%)
		TM helix 3	1575..1620	CDD:350046	16/44 (36%)
		TM helix 4	1621..1670	CDD:350046	15/48 (31%)
		TM helix 5	1682..1727	CDD:350046	10/44 (23%)
		TM helix 6	1777..1810	CDD:350046	10/32 (31%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	98/220 (45%)
abc2	NP_593943.3	MRP_assoc_pro	96..1477	CDD:188098	464/2127 (22%)