DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and Abcc2

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_036965.1	Gene:	Abcc2 / 25303	RGDID:	2366	Length:	1541	Species:	Rattus norvegicus

Alignment Length:	2252	Identity:	511/2252 - (22%)
Similarity:	805/2252 - (35%)	Gaps:	867/2252 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LFQSSPRDL------NYLVVIGSGELWNALFSTLLT--LMLMLYHRMVERKKAT----------V 148
            |.:|...||      ..||.|..|.||      ||.  .:..:|....:|...|          |
  Rat    14 LLESPEADLPLCFEQTVLVWIPLGFLW------LLAPWQLYSVYRSRTKRSSITKFYLAKQVFVV 72

  Fly   149 FLYASTAVEALTFALLSN---ELFELVRYED-FLELQTCLVAMSAM-----CMVS---------- 194
            ||....|:: |:.||..:   .....|||.: .|.|.|.|:.::..     |:..
  Rat    73 FLLILAAID-LSLALTEDTGQATVPPVRYTNPILYLCTWLLVLAVQHSRQWCVRKNSWFLSLFWI 136

  Fly   195 LAMLDGLTVYKECYHDDYLDDYGKIGYKHSM-----------------------------ATFYS 230
            |::|.|:..::........|....:.|.:..                             |:|.|
  Rat   137 LSVLCGVFQFQTLIRALLKDSKSNMAYSYLFFVSYGFQIVLLILTAFSGPSDSTQTPSVTASFLS 201

  Fly   231 KSCFWWLTPLLWLGYKEPLELEDLG------------------------------QMKLEDSAR- 264
            ...|.|....:..|||.||.|||:.                              |.:|:.|.|
  Rat   202 SITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQKARQAFQRRLQKSQRK 266

  Fly   265 -----------SHYDHFLYIYTEKKKKSNSS----PSLWYCYIKNSWQMFAL----GGILKLAGD 310
                       ......:.:..|.||||..:    |..|  .||:.::.|.:    ..||||..|
  Rat   267 PEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSW--LIKSLFKTFHVVILKSFILKLIHD 329

  Fly   311 LFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIY 375
            |...:.|..::.::.::            ||..:.|
  Rat   330 LLVFLNPQLLKLLIGFV------------KSSNSYV----------------------------- 353

  Fly   376 SSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCD 440
               |.     |:..|.::....:.|....|:......:.|:.::|::...||:|:|
  Rat   354 ---WF-----GYICAILMFAVTLIQSFCLQSYFQHCFVLGMCVRTTVMSSIYKKAL--------- 401

  Fly   441 SSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIH 505
                      |.|....||                     :.||...|.|:.|::.:|:....:.
  Rat   402 ----------TLSNLARKQ---------------------YTIGETVNLMSVDSQKLMDATNYMQ 435

  Fly   506 YAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTP----LQFFIGNAMSKNAEVIAGYTDERL 566
            ..|:...:|.:.|:.|:..||.| ::..:..:|::.|    |...|.|...:|.:    ..|:||
  Rat   436 LVWSSVIQITLSIFFLWRELGPS-ILAGVGVMVLLIPVNGVLATKIRNIQVQNMK----NKDKRL 495

  Fly   567 KRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGV 631
            |.:::.|.|||::|..||:..|.:::|..|:||||.|.:.....:|:..:..|..:|::.||..|
  Rat   496 KIMNEILSGIKILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIFILQITPILVSVVTFSV 560

  Fly   632 YVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFE 696
            ||.:  |....|||.:.|:|:.||..|..||.:.|:....|:.|.||..||||:|
  Rat   561 YVLV--DSANVLNAEKAFTSITLFNILRFPLSMLPMVTSSILQASVSVDRLERYL---------- 613

  Fly   697 GIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEE 761

  Rat   614 ----------------------------------------------------------------- 613

  Fly   762 SAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDS 826
            ..:|:..|.::                                          |..|.|.
  Rat   614 GGDDLDTSAIR------------------------------------------RVSNFDK----- 631

  Fly   827 LLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEM 891
                     ||..::..|||.|..:..:..:::.   :..|:|..|||..||||:||:||:|.||
  Rat   632 ---------AVKFSEASFTWDPDLEATIQDVNLD---IKPGQLVAVVGTVGSGKSSLVSAMLGEM 684

  Fly   892 PLLAGNMFWHKTC--TISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRG 954
            .    |:..|.|.  :.:||.||.|:.|.||::|||||..:..|:|..||:||||.||:|::|.|
  Rat   685 E----NVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQVLKACALLPDLEILPGG 745

  Fly   955 DLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRT 1019
            |::.|||:|||:||||:||:::|||.|..|::.|:||||:::|..||:|||...:......:.:|
  Rat   746 DMAEIGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFNKVVGPNGLLAGKT 810

  Fly  1020 FILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGE 1084
            .|.||..:|.:.:.:.::.:..|.:...|||.|:...:......|...:     |:..|.   ||
  Rat   811 RIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVFARNWKTFM-----KHSGPE---GE 867

  Fly  1085 KTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPI 1149
            .|                                           .|..|...::||.:
  Rat   868 AT-------------------------------------------VNNDSEAEDDDDGL------ 883

  Fly  1150 GNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSG 1214
                                      :| .::|...|...:..||.::|.|..||::.||.|
  Rat   884 --------------------------IP-TMEEIPEDAASLAMRRENSLRRTLSRSSRSSSR--- 918

  Fly  1215 LSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLS 1279

  Rat   919 ----------------------------------------------------------------- 918

  Fly  1280 RNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSA 1344
                                                         |..|::.|.|.||
  Rat   919 ---------------------------------------------RGKSLKNSLKIKN------- 931

  Fly  1345 TNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELR 1409
                              .::|      .|.:.|.:.:|.:..:..||
  Rat   932 ------------------VNVL------KEKEKEVEGQKLIKKEFVET----------------- 955

  Fly  1410 ANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAG----L 1470
                                                        ||:...|||.|::|.|    |
  Rat   956 --------------------------------------------GKVKFSIYLKYLQAVGWWSIL 976

  Fly  1471 PIITIFFITALIWQCLRVYTDIWLQQWS----NVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAI 1531
            .||..:.:..:.:    :.:::||..|:    |::|...|..|       :|..:    .::.|:
  Rat   977 FIILFYGLNNVAF----IGSNLWLSAWTSDSDNLNGTNNSSSH-------RDMRI----GVFGAL 1026

  Fly  1532 SCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKI 1596
            .....|..|:||....||..||.:.||.:||..||...:.||..||.||||||||.|::.:|..:
  Rat  1027 GLAQGICLLISTLWSIYACRNASKALHGQLLTNILRAPMRFFDTTPTGRIVNRFSGDISTVDDLL 1091

  Fly  1597 AATGQRLLQFTLLC---LSAILINVTI-TPWILVLTLPICGAYYLIQKFYRCSARELQRIENATN 1657
            ..|    |:..::|   ::..|:.:.: ||...::.:|:...|..:|.||..::|:|:|:::.|.
  Rat  1092 PQT----LRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSILYISVQVFYVATSRQLRRLDSVTK 1152

  Fly  1658 SPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFV 1722
            ||:.||.|||:.|:..||||..|.||.....|:::.|........||:|||.:.|:.:|..:||.
  Rat  1153 SPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCVFSWITSNRWLAIRLELVGNLVVFC 1217

  Fly  1723 ATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYL 1787
            :.:..:.         |..|.                         :..:||..::..|.:...|
  Rat  1218 SALLLVI---------YRKTL-------------------------TGDVVGFVLSNALNITQTL 1248

  Fly  1788 NWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQS 1852
            ||:|::.::.|....:||||:.|.
  Rat  1249 NWLVRMTSEAETNIVAVERISEYI----------------------------------------- 1272

  Fly  1853 DAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHL 1917
                                                    ..||.|....||
  Rat  1273 ----------------------------------------NVENEAPWVTDK------------- 1284

  Fly  1918 NFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDI 1982
               .|||                                                  .||:.|:|
  Rat  1285 ---RPPA--------------------------------------------------DWPRHGEI 1296

  Fly  1983 HFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDI 2047
            .|:|..:||..:...|:..:|..|.:|:::|:.||||:|||||...||.:|::..|.|.||.:|:
  Rat  1297 QFNNYQVRYRPELDLVLKGITCNIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDV 1361

  Fly  2048 QRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTV 2112
            ..|...:||.||:|||||..||:.::|.||||...:.|.::|..||||.|:.||:| |.|||.:.
  Rat  1362 ASIGLHDLRERLTIIPQDPILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFVSG-LQLGLLSE 1425

  Fly  2113 ICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHR 2177
            :.:||.|||.|.||||||.||:||.|..|||||||:.:|..|:|.:.......|...|:||||||
  Rat  1426 VTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHR 1490

  Fly  2178 LTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLEKG 2219
            |.||:|.|:::|||.|:|||.|:|.||....||.:....|.|
  Rat  1491 LHTIMDSDKIMVLDNGKIVEYGSPEELLSNRGSFYLMAKEAG 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
Abcc2	NP_036965.1	MRP_assoc_pro	7..1533	CDD:188098	511/2252 (23%)
		ABC_membrane	322..589	CDD:279056	80/362 (22%)
		ABCC_MRP_domain1	633..834	CDD:213217	84/207 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..881		6/64 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..923		9/134 (7%)
		ABC_membrane	979..1245	CDD:279056	84/318 (26%)
		ABCC_MRP_domain2	1294..1514	CDD:213211	107/220 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.110