Protein Alignment Sur and Abcc12

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_766500.3
• Gene: Abcc12 / 244562
• MGIID: 2441679
• Length: 1366
• Species: Mus musculus
• Alignment Length: 2042
• Identity: 442/2042 - (21%)
• Similarity: 727/2042 - (35%)
• Gaps: 765/2042 - (37%)

  Fly   213 LDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEK 277
            :||.|.:    |.|||.      ||||::...||..|.::.|..:...||:..:...|..::.|:
Mouse    46 VDDAGLL----SFATFS------WLTPVMIRSYKHTLTVDTLPPLSPYDSSDINAKRFQILWEEE 100

  Fly   278 KK-----KSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGP-LAIQKIVEYIEQLYAQASE 336
            .|     |::....:|. :.:....|..:..||.:   :.|.:|| :.|.:|:::|..:
Mouse   101 IKRVGPEKASLGRVVWK-FQRTRVLMDVVANILCI---VMAALGPTVLIHQILQHITSI------ 155

  Fly   337 PPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQG 401
                |.|:....:.|..: :..|||.:|.                    .|.:||.
Mouse   156 ----SSGHIGIGICLCLA-LFTTEFTKVL--------------------FWALAWA--------- 186

  Fly   402 ALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMA 466
                    |...|.||:|.:|..||:...|                                |..
Mouse   187 --------INYRTAIRLKVALSTLIFENLL--------------------------------SFK 211

  Fly   467 TPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVI 531
            |..|:          ..|.:.|.::.|:.::.|..|.......||..:.|.....:..||.:|::
Mouse   212 TLTHI----------SAGEVLNILSSDSYSLFEAALFCPLPATIPILMVVCAVYAFFILGSTALV 266

  Fly   532 GSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEAR 596
            | |:..:|..|:|.|:....|.........||:|::.:::.|..||:||:.||:|.|:..|.:.|
Mouse   267 G-ISVYLIFIPIQMFMAKLNSTFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEESFINTIHDIR 330

  Fly   597 RKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVP 661
            ::|.|.|.|.....:..:.|..|.:.:....|...:::|.|    .|.|...||.:|:|..:...
Mouse   331 KREKKLLEKAGYVQSGNSALAPIVSTIAIVSTFTCHIFLKR----KLTAPVAFSVIAMFNVMKFS 391

  Fly   662 LLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEK------ 720
            :.|.|.:|..:..|.||.||:::.|                  ::||..|   |.||.:
Mouse   392 IAILPFSVKAVAEASVSLRRMKKIL------------------IAKSPPS---YITQPEDPDTIL 435

  Fly   721 --SNMTMRTAQAENRLN-------EKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGH 776
              :|.|:...|..||.:       :||...|.|.|||         .:|:|..|
Mouse   436 LLANATLTWEQEINRKSDPPKAQIQKRHVFKKQRPEL---------YSEQSRSD----------- 480

  Fly   777 NKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSIND 841
                                                                            .
Mouse   481 ----------------------------------------------------------------Q 481

  Fly   842 GLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTI 906
            |:.:.:.||..|...||....:|.|||:..:.|..||||:||:||||.:|.|..|.:..:.  .:
Mouse   482 GVASPEWQSGSPKSVLHNISFVVRKGKVLGICGNVGSGKSSLISALLGQMQLQKGVVAVNG--PL 544

  Fly   907 SYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQR 971
            :|||||.|:.:..:||||||||.:..:||...:..|.|:.|:..:|.|||:.|||||:|:|||||
Mouse   545 AYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLNSLPYGDLTEIGERGVNLSGGQR 609

  Fly   972 QRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYL 1036
            |||::|||:|::..:.::||||:::|..||:|:|:.||::.|:  .:|.:|||.||..::..:.:
Mouse   610 QRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEECIKKTLK--GKTVVLVTHQLQFLESCDEV 672

  Fly  1037 IAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLG 1101
            |.::||  |.|......|||:.|                            |...||:
Mouse   673 ILLEDG--EICEKGTHKELMEER----------------------------GRYAKLI------- 700

  Fly  1102 LQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSI 1166
                                                                             
Mouse   701 ----------------------------------------------------------------- 700

  Fly  1167 YGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDV 1231
                                                       |.|.||
Mouse   701 -------------------------------------------HNLRGL---------------- 706

  Fly  1232 LSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVK 1296
                                             .::.|:|:               ..||..:..
Mouse   707 ---------------------------------QFKDPEHI---------------YNVAMVETL 723

  Fly  1297 KSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHF 1361
            |...|:|..                                        :::|:..:|.
Mouse   724 KESPAQRDE----------------------------------------DAVLASGDEK------ 742

  Fly  1362 PASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERH 1426
                  .:|.:.||:.        .:|                        |::||        |
Mouse   743 ------DEGKEPETEE--------FVD------------------------TNAPA--------H 761

  Fly  1427 VLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAG-----LPIITIFFI-----TAL 1481
            .|.:.  ||.:|               |.::...|..||:|:|     ..::.:||:     ...
Mouse   762 QLIQT--ESPQE---------------GIVTWKTYHTYIKASGGYLVSFLVLCLFFLMMGSSAFS 809

  Fly  1482 IWQCLRVYTDIWLQQWSNV-----HGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALV 1541
            .|     :..|||.:.|.|     :.:.|......|    ||.:...|..:|.|.....::..::
Mouse   810 TW-----WLGIWLDRGSQVVCASQNNKTACNVDQTL----QDTKHHMYQLVYIASMVSVLMFGII 865

  Fly  1542 STPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQF 1606
            ...........|..:||:::...|:...:.||..||.||::||||.||..:|.::....:..||.
Mouse   866 KGFTFTNTTLMASSSLHNRVFNKIVRSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQ 930

  Fly  1607 TLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGV 1671
            ..:.:..::|...:.|.:||:...:...:.::.:.:....:||:::||.:.||..||::.:|||:
Mouse   931 FFMVVFILVIMAAVFPVVLVVLAGLAVIFLILLRIFHRGVQELKQVENISRSPWFSHITSSIQGL 995

  Fly  1672 TTIRAFNQQTRFTEILFKRLEANTIAYAL-LNTSHRWLGVSLDYLGGCIVF-VATVTALTAASVS 1734
            ..|.|::::..... .||.|.....::.| .|.:.||..:.:|.|...:.| ||.:..|:.:|:|
Mouse   996 GVIHAYDKKDDCIS-KFKTLNDENSSHLLYFNCALRWFALRMDILMNIVTFVVALLVTLSFSSIS 1059

  Fly  1735 CRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEM 1799
            .                                   |..||:::|.:.:...|...|:...:.:.
Mouse  1060 A-----------------------------------SSKGLSLSYIIQLSGLLQVCVRTGTETQA 1089

  Fly  1800 YAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATT 1864
            ...|.|.:..|.                    |...|.
Mouse  1090 KFTSAELLREYI--------------------LTCVPE--------------------------- 1107

  Fly  1865 AAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDK 1929
                                                                   |..|...|
Mouse  1108 -------------------------------------------------------HTHPFKVG-- 1115

  Fly  1930 VEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQ 1994
                                                     :.|..||.||:|.|.:..:||...
Mouse  1116 -----------------------------------------TCPKDWPSRGEITFKDYRMRYRDN 1139

  Fly  1995 KQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRL 2059
            ...|:..|.|.|.:||.:||.|||||||||||::||.:::...|.|.||:|||..:..::|||:|
Mouse  1140 TPLVLDGLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIIIDEVDICTVGLEDLRTKL 1204

  Fly  2060 SIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGH 2124
            ::||||..||..|:|.||||.|...|..||:.||...:::.:. .||..|...:.:.|.|.|.|.
Mouse  1205 TMIPQDPVLFVGTVRYNLDPLGSHTDEMLWHVLERTFMRDTIM-KLPEKLQAEVTENGENFSVGE 1268

  Fly  2125 RQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIV 2189
            |||||:|||:||.|..::|||||:.:||.|::.:......||:..|::||||||.|:|:.|.::|
Mouse  1269 RQLLCMARALLRNSKIILLDEATASMDSKTDTLVQSTIKEAFKSCTVLTIAHRLNTVLNCDLVLV 1333

  Fly  2190 LDQGRIVEDGNPRELQQLEGSVFRGLL 2216
            ::.|:::|...|..|.:...|.|..||
Mouse  1334 MENGKVIEFDKPEVLAEKPDSAFAMLL 1360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	84/381 (22%)
		TM helix 1	301..324	CDD:350035	6/23 (26%)
		TM helix 2	385..433	CDD:350035	12/47 (26%)
		TM helix 3	480..525	CDD:350035	8/44 (18%)
		TM helix 4	526..575	CDD:350035	13/48 (27%)
		TM helix 5	587..631	CDD:350035	10/43 (23%)
		TM helix 6	648..681	CDD:350035	10/32 (31%)
		ABCC_MRP_domain1	837..1043	CDD:213217	85/205 (41%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	74/347 (21%)
		TM helix 1	1475..1496	CDD:350046	6/25 (24%)
		TM helix 2	1520..1568	CDD:350046	7/47 (15%)
		TM helix 3	1575..1620	CDD:350046	14/44 (32%)
		TM helix 4	1621..1670	CDD:350046	12/48 (25%)
		TM helix 5	1682..1727	CDD:350046	12/46 (26%)
		TM helix 6	1777..1810	CDD:350046	5/32 (16%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	96/220 (44%)
Abcc12	NP_766500.3	MRP_assoc_pro	43..1366	CDD:188098	442/2042 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	470..492		9/105 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	726..749		5/74 (7%)