Protein Alignment Sur and Abcc10

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001334325.1
• Gene: Abcc10 / 224814
• MGIID: 2386976
• Length: 1526
• Species: Mus musculus
• Alignment Length: 2334
• Identity: 499/2334 - (21%)
• Similarity: 799/2334 - (34%)
• Gaps: 960/2334 - (41%)

  Fly    22 DNLNTDICGIDRVR-----------RVFTFFSIFLLLFGLMFVCSRYKKCH----KTLLTFHNG- 70
            :.|...:||.|..|           ..||...:..|...|:.|.|   .||    :|  |.|:.
Mouse     2 EGLLAQLCGTDAARPLPLWEGDTTGHCFTQLVLSALPHALLAVLS---ACHLGTPRT--TNHSPA 61

  Fly    71 -------RAAISLLLLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFST 128
                   |.|.|.||......||..:.||.          .|.|           |.||..:.:.
Mouse    62 LNPGWRLRLAASFLLSIFPLLDLLPVVLPP----------GSRP-----------GPLWLEVLAG 105

  Fly   129 LLTLMLMLYHRMV-----------ERKKATVFLYASTAVEALTFALLSNELFELVRYEDFLEL-- 180
            .:|.:....|.:.           .|....:.|.|.....||...||.:     .:...||..
Mouse   106 CVTAVAWFTHSLALWALVHSPHGRSRGPLALALAAFLPTPALVLTLLWH-----CQRGTFLPPLL 165

  Fly   181 -----QTCLVAMSAMCMVSLAMLDGLTV----YKECYHDDYLDDYGKIGYKHSMA----TFYSKS 232
                 :.||:.:....:::..:  |...    .:...||.:|....:   :..:|    ::.|:.
Mouse   166 PGPLGRVCLLILQLAAVLAYGL--GWAAPGGPQEPWTHDPFLSSESQ---ETEVAEDGESWLSRF 225

  Fly   233 CFWWLTPLLWLGYKEPLELEDLGQMKLEDSA----RSHYDHFLYIYTEKKKKSNSSPSLW----- 288
            .:.||.|||..|.:..|:       :..|:.    |.|......::....|:   ...||
Mouse   226 SYAWLAPLLARGVRGELQ-------QPRDTCRLPRRLHPAFLARVFQAHWKE---GAQLWRALYR 280

  Fly   289 ---YCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVL 350
               .||:       || |:||:.|.:....|||.:..:|.::|    :..||        :::.|
Mouse   281 AFGCCYL-------AL-GLLKMVGTMLGFSGPLLLSLLVGFLE----EGQEP--------LSHGL 325

  Fly   351 LSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTG 415
            |   .:||                        ||.|      .:::|:.|   :|....:..:|
Mouse   326 L---YVLG------------------------LAGG------TVISAVLQ---NQYGYEVRKVT- 353

  Fly   416 IRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNIS 480
            ::.:.::...:|||:|.|                                       .||.|
Mouse   354 LQARVAVLSTLYRKALKL---------------------------------------GPSRP--- 376

  Fly   481 HDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQF 545
             ..|.:.|.:..|:..::.|....|.||.:|.::|:.:||||..:|::.:.|.:..::::...:.
Mouse   377 -PTGEVLNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGMAFLAGLVLALLLVPVNKV 440

  Fly   546 FIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKEL------KYLN 604
            .....|:.|.|::. :.|.|:|.:.:.|.||:|||...|::....:::..|.|||      |||:
Mouse   441 IATRIMASNQEMLR-HKDARVKLMTELLSGIRVIKFFRWEQALGDRVKACRTKELGRLRVIKYLD 504

  Fly   605 KDATF-WTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPIT 668
            ....: |..:.|:..| |:.||:|.:|     |:     |.|:::|::|||.:.|.:||..||..
Mouse   505 AACVYLWAALPVVICI-TIFITYVLMG-----HQ-----LTATKVFTALALVRMLILPLNNFPWV 558

  Fly   669 VPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENR 733
            :..::.::||..|::||                          ||:
Mouse   559 INGLLESKVSLDRIQRF--------------------------LDL------------------- 578

  Fly   734 LNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPP 798
                    .|.:||...:..|       .||   |||
Mouse   579 --------PSYSPEAYYSPDP-------PAE---PST---------------------------- 597

  Fly   799 KMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQP--QSQMPVVQLHVPG 861
                                                 |:.:::.||:|.|  .||...:. |:.
Mouse   598 -------------------------------------ALELHEALFSWDPIGASQKTFIS-HLQ- 623

  Fly   862 IIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTIS----YVSQQPWLLNDTIRE 922
              |.||.|..:|||.|.||:|||:|:..|:..|.|   |.....:|    ..:|:||:...|||:
Mouse   624 --VKKGMLVGIVGKVGCGKSSLLAAITGELHRLCG---WVAVSELSKGFGLATQEPWIQCATIRD 683

  Fly   923 NILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVV 987
            |||||::|..:.|..|||||||..|:.::|.||.:.:||:|:.:|||||.|||:|||:|....:.
Mouse   684 NILFGKTFDAQLYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKALY 748

  Fly   988 IMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYAD 1052
            ::|||||::|.:|..|:...||..:|  |:.|.:|.|.:...::.|:.::.::.|::...|..::
Mouse   749 LLDDPLAAVDADVANHLLHRCILGVL--SHTTRLLCTHRTEYLERADVVLLMEAGQLVRTGPPSE 811

  Fly  1053 IELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACH 1117
            |
Mouse   812 I---------------------------------------------------------------- 812

  Fly  1118 ADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDE 1182
                                                                        ||
Mouse   813 ------------------------------------------------------------LP--- 814

  Fly  1183 CQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAES 1247
                                                                             
Mouse   815 ----------------------------------------------------------------- 814

  Fly  1248 SVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPL 1312
                  |..|.|    .:|...:.|.                                ||.:||
Mouse   815 ------LVQAVP----TAWAEKEQVA--------------------------------TSGQSP- 836

  Fly  1313 DDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQS 1377
                                              |:..:                      |..:
Mouse   837 ----------------------------------SVCDL----------------------ERTT 845

  Fly  1378 EEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPL 1442
            ||:      ::.:::|..|
Mouse   846 EEE------LEVEQSTCGC---------------------------------------------- 858

  Fly  1443 ARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQW---------- 1497
              |..:..:..|.::..:|..|.||.|..:.....::.|:.|..|...|.||..|
Mouse   859 --LVQEESKSEGAVALHVYRAYWRAMGSGLAAAILVSLLLMQATRNGADWWLAHWLSQLKAGRNG 921

  Fly  1498 ------SNVHGRVA---------SKGHVV-------LH--PSEQDHEVTYYFRMYAAISCV---C 1535
                  |...|..|         |.|::.       ||  .|....:|.:|..:||.|:.|   |
Mouse   922 SREDPASCSPGSTALFSPRLLLFSPGNLYTPLLSTPLHKAASNGTADVHFYLIVYATIAGVNSLC 986

  Fly  1536 IIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATG 1600
            .::..|...||   ...|..:||.:||..:|...:.|:..||.||::||||:|:|.:|..:....
Mouse   987 TLLRAVLFAAG---ALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLL 1048

  Fly  1601 QRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLS 1665
            ..||..::..|..:.:..:..||:|:|..|:...||.:|.:||.|.|||:|:.:.|.||:.|||:
Mouse  1049 NILLANSVGLLGLLAVLGSGLPWLLLLLPPLSFVYYSVQGYYRASFRELRRLGSLTWSPLYSHLA 1113

  Fly  1666 ETIQGVTTIRAFNQQTRFTEILFKRLEANT----IAYALLNTSHRWLGVSLDYLGGCIVFVATVT 1726
            :|:.|:..:||.....||.|...:.||.|.    .:||.:    :||.:.|..:|     .|.|:
Mouse  1114 DTLAGLPVLRAAGATYRFEEENQRLLELNQRCQFASYATM----QWLDIRLQLMG-----AAVVS 1169

  Fly  1727 ALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVV 1791
            |:  |.::..:|.:...                         :|.||||.::|.|.:...|:.:|
Mouse  1170 AI--AGIALVQHQQGLA-------------------------NPGLVGLVLSYALSLTGLLSGLV 1207

  Fly  1792 KLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGD 1856
            ......|....||||:..|:                  .|:..||
Mouse  1208 SSFTQTEAMMVSVERLEEYS------------------CDVPQEP-------------------- 1234

  Fly  1857 KVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHH 1921
                                                                           |.
Mouse  1235 ---------------------------------------------------------------HS 1236

  Fly  1922 PPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDN 1986
            .|.                   |.|.||                       .|||..:|.:.|.:
Mouse  1237 QPL-------------------QSPHQQ-----------------------RISWLTQGSVEFQD 1259

  Fly  1987 VSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIR 2051
            |.|.|.....|.:..:|.::..|:::||.||||||||||.|.||.:|:...|.:.:|:||..::.
Mouse  1260 VVLVYRPGLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPNAGRVLLDNVDTSQLE 1324

  Fly  2052 PDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFV--------------- 2101
            ..|||::|::|||:..||:.||||||||.|..:|..||..||...|.|..
Mouse  1325 LAELRSQLAVIPQEPFLFSGTIRENLDPQGLHEDRALWQALEQCHLSEVAVAMGESQACQRSQRE 1389

  Fly  2102 --NGH------LPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESAL 2158
              |||      |..|||..:.:.|.|||.|.|||||||||:|..:..|.:||||:.:|..|:..|
Mouse  1390 AKNGHWQCSALLTGGLDGELGERGQNLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLL 1454

  Fly  2159 LKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLE 2217
            .:.....|..:|::||||||.|||:.||::||..||:||..:|..|:....|:|:.||:
Mouse  1455 QQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQPHSLFQQLLQ 1513

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010