Protein Alignment Sur and mrp-8

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_499598.2
• Gene: mrp-8 / 190710
• WormBaseID: WBGene00003414
• Length: 1461
• Species: Caenorhabditis elegans
• Alignment Length: 2213
• Identity: 500/2213 - (22%)
• Similarity: 786/2213 - (35%)
• Gaps: 833/2213 - (37%)

  Fly    65 LTFHNGRAAISLLLLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTL 129
            |.|.:..|||.||...|......||...::......:.|.:. ..|..|:::.     ||:|..|
 Worm    18 LLFRDAIAAIPLLAFWLLIPVFVRIIRDNEPKLRAPKYFWAH-LILQVLLLVD-----NAVFGAL 76

  Fly   130 --------LTLMLMLYHRMVERKKATVFLYASTAVEALTFALLSNELFELVRYEDFLELQTCLVA 186
                    |.|:..|          .|..||:..:   .|:|||..|..:  :..|     ||:.
 Worm    77 YFNQTDHFLPLLRFL----------QVLSYANCCI---WFSLLSKRLHSI--HPSF-----CLIF 121

  Fly   187 MSAMCMVSLAMLDGLTVYKECYHDDYL---------------------DDYGKIGY-KHSMATFY 229
            :..:.:.::.:|  :.|::..:.....                     :|..||.. ....::|.
 Worm   122 LILLVLKAVQVL--VLVFESTFDAGVTAEFVLLMAETALLASSTKRLGEDEQKIEQTPEEKSSFL 184

  Fly   230 SKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYT--------EKKKKSNSSPS 286
            ||..|.||.||:..|.|:||..|.|  ..|.::|.|.     ::||        ||..:.:...|
 Worm   185 SKIFFCWLNPLIRAGAKQPLTNESL--HNLNENATSE-----WLYTRWRAEFDKEKAGRKSGETS 242

  Fly   287 LWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLL 351
            :.:.:|:..........:.:|..|:...:.|:.::::::|: .|:.|.                |
 Worm   243 IVWPFIRIQRATIITLTLARLTADIVHYLNPILLKQLIDYV-SLHDQP----------------L 290

  Fly   352 STSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGI 416
            |            ||..|..:....||...||.| :.||.:...|...|..||.|..|.:    :
 Worm   291 S------------FGIAIACIMFSCSTTRSLLQN-YQIAGMCRQAVYYQTVLSNAILHKI----L 338

  Fly   417 RIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISH 481
            |:..|.:                 |:.:||:
 Worm   339 RLSPSAR-----------------SNRTAGE---------------------------------- 352

  Fly   482 DIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIM-TPLQF 545
                |.||...|...|:.....:...|::||::.:.:.:|.:.||.:|:.|  .||:|: .||..
 Worm   353 ----ILNHAAVDIEIIVHSVPYLQNMWSVPFQVTLAMTMLAITLGWAAMAG--VCIMILFIPLNL 411

  Fly   546 ----FIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKD 606
                ||..:..|..::    .|||.|..::.|.||||:||.||:|.|..:|...|.||:|.|...
 Worm   412 CTSRFIKLSQQKQMKI----KDERTKLSNEMLNGIKVVKLYAWEESFEDQINRLRAKEVKMLRNV 472

  Fly   607 ATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPI 671
            .....::.|....:..|:...:...|| |....|..|..|..|.:|.:|.||..|:.:....:..
 Worm   473 CILSRIVDVANAASPFLVAIGSFTCYV-LWSPDENGLTPSVAFVALTIFNQLRQPMRMVANLINT 536

  Fly   672 IIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNE 736
            ::.||||.:||.:||...|::::
 Worm   537 LVQARVSNKRLRQFLNDEEMERK------------------------------------------ 559

  Fly   737 KRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMR 801
                     .|:|..:..:.:||
 Worm   560 ---------TEVALGNAIVFKNA------------------------------------------ 573

  Fly   802 GSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPK 866
                                                |:|     |:.....||:: .:...|.|
 Worm   574 ------------------------------------SLN-----WKGPQNPPVLK-DLSATIKP- 595

  Fly   867 GKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFR 931
            |:|..:||..|.||:|||||:|.||.||.|.:  ....:|:||.|..|:.|.||:||||||....
 Worm   596 GQLIAIVGSVGGGKSSLLSAVLDEMVLLDGRV--KVGGSIAYVPQHSWIFNKTIKENILFGNELS 658

  Fly   932 PKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASL 996
            ...||.|:.:|.||.|.....:|:.:::||.||.:||||:.||::|||:|...::.::||||:::
 Worm   659 NYFYDQVVGSCQLKTDFRHFQQGENTMVGENGITLSGGQKARISLARAVYQDKDIYLLDDPLSAV 723

  Fly   997 DNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRIT 1061
            |..||..:|...|.......::|.:|||..|...|..:.:..|:||::...||:.||
 Worm   724 DAHVGRALFDKVIGPDGLLRSKTRVLVTHNLQYTKYVDTIYVIEDGQIVQHGSFEDI-------- 780

  Fly  1062 AEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGC 1126
                       |..|.|        .|..|                                |.|
 Worm   781 -----------AYVDGP--------FGRLW--------------------------------SEC 794

  Fly  1127 ISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMR 1191
               .|...:|.:|:
 Worm   795 ---ENSDEDVADEE--------------------------------------------------- 805

  Fly  1192 PRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLAT 1256
                                          :|||                    |:||
 Worm   806 ------------------------------AESS--------------------EASV------- 813

  Fly  1257 AAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPD---VKKSEEARRSNTSSESPLDDHVRG 1318
                                       :||...:.|.|   ::||.:..|:|:
 Worm   814 ---------------------------TPPVPVLENGDNGAIEKSSQIDRTNS------------ 839

  Fly  1319 SFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKK 1383
                                                     ||         ::...:|||||:|
 Worm   840 -----------------------------------------HF---------SEKSRKSEEKPQK 854

  Fly  1384 CVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAID 1448
            .                                       |::|          |::.|
 Worm   855 V---------------------------------------EKNV----------ENVQL------ 864

  Fly  1449 TERKYGKISDDIYLMYIRAAGL---PIITIFFITALIWQCLRVYTDIWLQQWSNVHGRV----AS 1506
                 |::...:|.:||:..|:   ....||||.......:|   .:||..|||.:..:    .|
 Worm   865 -----GRVKKSVYQLYIKTMGIFNSSAFLIFFIAHFTVMIMR---SLWLSDWSNENAAIKKATLS 921

  Fly  1507 KGHVVLHPSEQDHEVTYYFRM--YAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKT 1569
            ....:...|..|..|:...|:  ||....:.:::..::..........|...||..|:..:|...
 Worm   922 SVDYLNSTSSVDGPVSVETRLIVYAGFGGLEMLLLALAFTVLTIGSLRASYGLHSPLIHALLVAP 986

  Fly  1570 LHFFQVTPLGRIVNRFSNDMAVIDK---KIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPI 1631
            :.||..||.|||:||.|.|:.||||   .|....|.||.   .|:..:||::: ||..||...|:
 Worm   987 ISFFDTTPTGRIINRLSRDLDVIDKLQDNIRMCTQTLLN---ACMILVLISIS-TPIFLVCAAPL 1047

  Fly  1632 CGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTI 1696
            ...||.:..:|..::|:|:|:|:|..||::|.::|:|.|.::||||::..|.|..|...::....
 Worm  1048 ILIYYFVMIYYIPTSRQLKRLESANRSPILSTIAESIHGASSIRAFDKTERTTTALSTNVDKFAQ 1112

  Fly  1697 AYALLNTSHRWLGVSLDYLGG-CIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVT 1760
            ...|.:.|:|||...|:.||. |::|         ||:|                        .|
 Worm  1113 CRYLSHMSNRWLATRLELLGNTCVLF---------ASLS------------------------AT 1144

  Fly  1761 KSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADAD 1825
            .|......:|.:.||:::|.|.:...||..|:.::::|....||||:..|
 Worm  1145 LSTKYFGLTPGMAGLSVSYALTITEVLNICVRSVSEIESNIVSVERVNEY--------------- 1194

  Fly  1826 ADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGY 1890
                                          .|:.|.|
 Worm  1195 ------------------------------QKLEPEA---------------------------- 1201

  Fly  1891 RQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKK 1955
                                                                    |.:.:|.
 Worm  1202 --------------------------------------------------------PWRIEKS-- 1208

  Fly  1956 VVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGS 2020
              |.||.            .||.:|.|..|..|:||......|:.|:.|||..|:|||:.|||||
 Worm  1209 --LENEE------------KWPVKGKIELDGFSMRYRKNLPLVLKNIDLKIEGGERIGVIGRTGS 1259

  Fly  2021 GKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQD 2085
            |||||.::|:.:::...|.|.||||:|..|...:||::|.||||:..:|:.|:|.||||...:.|
 Worm  1260 GKSSLTMALYRMIEGESGTIKIDDVEIDTIGLHQLRSKLIIIPQEPVVFSGTLRFNLDPFNQYSD 1324

  Fly  2086 LQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVL 2150
            .|:|||||:.|||:|.... ...||..|.:||.|:|.|.||||||.||:|||:..::|||||:.:
 Worm  1325 DQIWNCLEICQLKQFAQED-DKTLDRYIAEGGKNMSVGERQLLCLCRALLRGARIVILDEATASV 1388

  Fly  2151 DSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGL 2215
            |:.|:..:.:|....|...|.|:|||||.||:|.||::|||.||:.|...|..|.....|::..|
 Worm  1389 DTVTDGIVQRAIRQHFPQSTTISIAHRLDTIVDSDRIVVLDAGRVAEFDTPSNLLLNPDSLYSQL 1453

  Fly  2216 LEK 2218
            |.:
 Worm  1454 LNE 1456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
mrp-8	NP_499598.2	CFTR_protein	173..1459	CDD:273530	465/2030 (23%)
		ABC_membrane	259..527	CDD:294371	84/363 (23%)
		ABCC_MRP_domain1	568..770	CDD:213217	80/288 (28%)
		ABC_membrane	887..1168	CDD:294371	90/320 (28%)
		ABCC_MRP_domain2	1219..1439	CDD:213211	105/220 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100