DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and haf-8

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_502776.1	Gene:	haf-8 / 190369	WormBaseID:	WBGene00001818	Length:	633	Species:	Caenorhabditis elegans

Alignment Length:	742	Identity:	156/742 - (21%)
Similarity:	273/742 - (36%)	Gaps:	237/742 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1511 VLHPSEQDHEVTYYFRM--YAAISCVCIIMALVSTPAG----------QYAGCNARRNLHDKLLQ 1563
            ::.|:.....:|...:|  :..|...|:::||:.....          |||.....||:..:|.:
Worm    72 LIEPALYGQMMTNAIQMKSFDIIKRACLLLALIQFSEATCKSACYFFMQYAEKLTARNIRIQLFR 136

  Fly  1564 TILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLT 1628
            :|||:.:.||.....|::|:|.::|...|...:....:.|:....:...:|.|....: |.|.||
Worm   137 SILHQEISFFDENKTGQLVSRITHDSESISNTLPVHIETLVNNLFMFFGSIPIMFCYS-WQLTLT 200

  Fly  1629 ----LPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFN----QQTRFTE 1685
                .||.   .|:.::|..:..:|...||...:.....:.|.:..:.|:|:|.    :|.|:|:
Worm   201 SFIEFPIT---LLMTRYYGLAVEKLSEKENDATAASNETVEEVLSAIRTVRSFAAENFEQKRYTK 262

  Fly  1686 ILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASAS 1750
                    ||..:..::|....||...:|.          .||...|....|:
Worm   263 --------NTEDWFKISTKTVTLGTIYNYF----------WALMLRSQDVIRY------------ 297

  Fly  1751 PSPFETYAVTKSPSELRPSPSLVG--LAIN-----YTLLVPIYLNWVV--KLLADMEMYAGSVER 1806
                                 |.|  ||:|     ..||..|:.:|.:  .:.|...:::|.::.
Worm   298 ---------------------LYGGYLALNGRMAPEALLTFIFYHWRLHTAINAFSSLFSGVMKT 341

  Fly  1807 IAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDE 1871
            |                             ..:..|...::|..|.|
Worm   342 I-----------------------------GLSRKVIHLINRKPQLD------------------ 359

  Fly  1872 DGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTK 1936
                              |..|                                         |:
Worm   360 ------------------YDFG-----------------------------------------TE 365

  Fly  1937 TSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQ-NVIS 2000
            |..|                                      :|.|.|:.|...|..:|. |||:
Worm   366 TPEI--------------------------------------QGKIEFEVVEFAYPTRKTVNVIN 392

  Fly  2001 NLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTR-GHIYIDDVDIQRIRPDELRTRLSIIPQ 2064
            .:.|.|.:|:.:.:.|.:|:|||:| :||.....|.: |.|..|.:.||.|......:.::::.|
Worm   393 GINLSIESGKTVALVGPSGNGKSTL-VSLIQQFYTPQSGRILTDGIPIQNINHQHYHSNIALVAQ 456

  Fly  2065 DVHLFNATIRENL---DPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQ 2126
            :..||:.|||||:   ..:|  .:..:....|:|.:.|||: .:..|.||...:.|:.:|.|.:|
Worm   457 EPTLFSGTIRENILFGIENG--TEEAMLKAAEMANVHEFVS-KMDDGYDTKCGEKGVQMSGGQKQ 518

  Fly  2127 LLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLD 2191
            .:.:|||::|....|:||||||.|||.:|..:.:|.:...:.||:|.|||||:|:....::.|::
Worm   519 RIAIARALIRNPRVLILDEATSALDSESEGMVQEALNKCAKERTVIVIAHRLSTVRKAQKIAVIE 583

  Fly  2192 QGRIVEDGNPRELQQLEGSVFRGLLEK 2218
            .|.:.|.|...||.:.:..::..|:.|
Worm   584 NGSVKEMGCHDELMENQDGLYYKLVSK 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
haf-8	NP_502776.1	MdlB	42..613	CDD:224055	156/742 (21%)
		ABC_membrane	63..318	CDD:279056	61/300 (20%)
		ABC_MTABC3_MDL1_MDL2	373..611	CDD:213216	80/242 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000