Protein Alignment Sur and pgp-7

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001361833.1
• Gene: pgp-7 / 188697
• WormBaseID: WBGene00004001
• Length: 1152
• Species: Caenorhabditis elegans
• Alignment Length: 1711
• Identity: 283/1711 - (16%)
• Similarity: 509/1711 - (29%)
• Gaps: 741/1711 - (43%)

  Fly   519 YLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNA 583
            :|..:.:..|.|.|  .|       |.|:...:.:.|:|:...|:         .:..|.|
 Worm    41 FLFLIGVFFSLVTG--LC-------QPFVSYTLGETAQVLVTITN---------AINNKTI---- 83

  Fly   584 WDEVFLKKIQEARRKE-------------------------LKYLNKDATFWTLMAVLTHIATVL 623
             |...|||..|...:.                         :||:..:.|:......::.:
 Worm    84 -DPADLKKAYEQYERGMYQVVLYFFLCGCAYFTFASIQHAIMKYVGDNTTYRVRKQYISRL---- 143

  Fly   624 ITFVTLGVYVWLHRDQEFDLNASR------LFSSLALFQQL--TVPLLIFPITVPIIIA---ARV 677
                       |.:|.|:..|.|.      |..:|..|:::  ....|||.:....::.   |..
 Worm   144 -----------LRKDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFY 197

  Fly   678 STRRLERFLKSSEIQKQFEGIRNMARIL--------------SKSDASLDMYET---QEKSNMTM 725
            :..||..:.....:...|.|..|.|.::              |.:..:|..|:|   ....|..:
 Worm   198 TDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQNTEI 262

  Fly   726 RTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEES-----------AEDISPSTVQELGHNKL 779
            .....|.:..||....::....::...|....|:..:           :..:.|:.|..:.|..:
 Worm   263 ERYTEELKAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANMIYSGSLEPAVVVRIFHYMM 327

  Fly   780 VQQ--RRELLRNTPYVAIRPPKMRGSVME-RPV------EFSVIRARNTDSWRRDSLLLKMPDDI 835
            ...  ..|.|   |:::    ::.|::.. .|:      |.:||....||.            |:
 Worm   328 FGAFCLSEAL---PHIS----RLAGAISSTAPIAEMLIKEDNVIEKDETDY------------DV 373

  Fly   836 AVSINDGL--------FTWQPQSQMPVVQLHVPGII--VPKGKLTIVVGKNGSGKTSLLSALLME 890
            .|.:|..:        :..:|.:|:      :.||.  |..|:...:||.:||||::::..||..
 Worm   374 EVEVNGNISFKNVKFSYPTRPDAQV------LKGISFDVQNGECIALVGASGSGKSTVVQLLLHY 432

  Fly   891 MPLLAGNMF-----------WHKTCTISYVSQQPWLLNDTIRENILFG-------ESF----RPK 933
            ..:.:||:|           ......|..|||:|.|.|.||.|||.||       |.:    :..
 Worm   433 YNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKAN 497

  Fly   934 RYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDN 998
            .||||   |:       .|:|..:|:||||..:||||:|||||||.:..:..::::|:..::|||
 Worm   498 AYDFV---CS-------FPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDN 552

  Fly   999 EVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAE 1063
            | .|.:.|..:....|  .||.|:|..:|..|:.|..:|.::.|.:...|::.::
 Worm   553 E-SEQVVQKALENASQ--GRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDEL---------- 604

  Fly  1064 WNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCIS 1128
                                             ::|.|:...:
 Worm   605 ---------------------------------IAKRGVYNDL---------------------- 614

  Fly  1129 VANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPR 1193
               :|:.::|..|......|:                  .:|.|..:              :.|.
 Worm   615 ---VQAQLLESHDDHEELPPL------------------AARQLSQE--------------LSPL 644

  Fly  1194 RRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAA 1258
            ..:.:.|                   :||..:.:..|.:.|.:
 Worm   645 HSYAIQR-------------------STSNDAGVHDDDMERIL---------------------- 668

  Fly  1259 PEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQF 1323
                                               |....|.|::||
 Worm   669 -----------------------------------DELSKEGAKKSN------------------ 680

  Fly  1324 LRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNID 1388
            ||                                                     |..|:|
 Worm   681 LR-----------------------------------------------------EIVKQC---- 688

  Fly  1389 SKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGES--GRESMPLARLAIDTER 1451
                   ..|.|:                         :...|.|.:  |.....||:|.:.|..
 Worm   689 -------RPDYCF-------------------------LFIAVFGSAIQGVSYPILAQLIVRTYE 721

  Fly  1452 KYGKISDD-IYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPS 1515
            .:..|.:| :|..::.|.....:.:|  ..|...|...|           .|:|:.:....|...
 Worm   722 GFAMIGEDMLYYSHLWALSFMFLAVF--RPLTLYCQYYY-----------FGKVSEQLSTRLRIK 773

  Fly  1516 EQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGR 1580
            ...|                    ::|.|...|...|              |...         |
 Worm   774 SFSH--------------------MLSLPCAFYDDPN--------------HSAT---------R 795

  Fly  1581 IVNRFSNDMAVIDKKIAATGQRL--LQFTLLCLSAILINVTITPWILVLTL----PICGAYYLIQ 1639
            :.||.:.|.:.:.   ||...||  :..|::.:|..:...::..|.:.|.:    |:   .||.:
 Worm   796 LSNRLNTDSSNVK---AAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFFPL---LYLAE 854

  Fly  1640 KFYRCSAR-ELQR----IENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAY- 1698
            ..|..:.. .:|.    .||:..:.:     |.::.:.|:||.|.:.:...::.:.|:....:|
 Worm   855 YCYDAATETSIQEDTIAFENSNRTAI-----EALENMRTVRALNLEDKIMSLISEHLQKIHKSYF 914

  Fly  1699 --ALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTK 1761
              |::..:...|.:|      |.:||.:|:......::.|:..            :|.:||.:.:
 Worm   915 KRAIIQGAANGLSLS------CYLFVYSVSFKFGTYLALRKEV------------APMDTYLILE 961

  Fly  1762 SPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADA 1826
            :   |..:.::.|.|..|              |.|
 Worm   962 T---LSMTANMAGSAAAY--------------LPD------------------------------ 979

  Fly  1827 DVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYR 1891
                                            |..|..|||
 Worm   980 --------------------------------YKKAVHAAG------------------------ 988

  Fly  1892 QGHENGAEANADKLNAGNVTGDGNHLNFH--HPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDK 1954
                                     |.||  ..|||                   :|....|..|
 Worm   989 -------------------------LIFHLFTYPAT-------------------MPFSSSDGKK 1009

  Fly  1955 KVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISN-LTLKIPAGQRIGICGRT 2018
            .:                     ::|:|..:||...|:.:...:|.| :.||:..|:.:.:.|.:
 Worm  1010 NI---------------------EKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPS 1053

  Fly  2019 GSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYF 2083
            |.|||::...|........|.:.||..:::.|..:.||:.|:::.|:..|||.:||||| .:|..
 Worm  1054 GCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENL-LYGLT 1117

  Fly  2084 Q---DLQLWNCLELAQLKEFV 2101
            :   .|:|...|:.|....||
 Worm  1118 RSVPQLELEKALQTANAFNFV 1138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
pgp-7	NP_001361833.1	MdlB	42..621	CDD:224055	140/722 (19%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	76/323 (24%)
		ABC_6TM_Pgp_ABCB1_D2_like	686..994	CDD:350022	79/556 (14%)
		TM helix 1	695..718	CDD:350022	6/22 (27%)
		TM helix 2	733..781	CDD:350022	9/80 (11%)
		TM helix 3	790..835	CDD:350022	12/70 (17%)
		TM helix 4	836..885	CDD:350022	10/56 (18%)
		TM helix 5	897..947	CDD:350022	9/55 (16%)
		TM helix 6	956..989	CDD:350022	13/160 (8%)
		P-loop_NTPase	1019..>1143	CDD:393306	37/121 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000